Antimicrobial laminate constructs

Abstract

The present invention comprises methods for making and using antimicrobial laminate constructs comprising an antimicrobial layer and optionally, an adhesive layer. The present invention comprises methods for making medical devices, surfaces that may be in contact with medical equipment, personnel or patients, or treatment areas antimicrobial comprising, for example, applying an antimicrobial laminate construct.

1 . A laminate construct comprising at least one antimicrobial layer comprising at least one antimicrobial agent and a binder, and a second layer. 
     
     
         2 . The laminate construct of  claim 1 , wherein an antimicrobial layer is contacting substantially all of the surface of one side of the second layer. 
     
     
         3 . The laminate construct of  claim 1 , wherein the antimicrobial layer comprises at least one antimicrobial agent comprising, an antibiotic, antiseptic, silver, silver salts, silver nanoparticles, ionic silver, combinations of one or more one silver compounds, zinc, copper, gold, and their salts, quaternary ammonium salts, isoniazid, ethambutol, pyrazinamide, streptomycin, clofazimine, rifabutin, fluoroquinolones, ofloxacin, sparfloxacin, rifampin, azithromycin, clarithromycin, dapsone, tetracycline, erythromycin, ciprofloxacin, doxycycline, ampicillin, amphotericin B, ketoconazole, fluconazole, pyrimethamine, sulfadiazine, clindamycin, lincomycin, pentamidine, atovaquone, paromomycin, diclazaril, acyclovir, trifluorouridine, foscarnet, penicillin, gentamicin, ganciclovir, iatroconazole, miconazole, Zn-pyrithione, chlorohexidine, polyhexamethylene biguanides, polyhexamethylene biguanides, triclosan, iodine, iodine-polyvinyl pyrrolidone complex, urea-peroxide complex, benzalkonium salts, turmeric extract, natural anti-infective compounds, or combinations thereof. 
     
     
         4 . The laminate construct of  claim 1 , wherein the antimicrobial layer further comprises one or more additives. 
     
     
         5 . The laminate construct of  claim 4 , wherein an additive comprises colorants, food colors, one or more types of fluorescent compounds, fillers, titania, natural or synthetic clays, humectants, glycerol, urea, glycols, polyethylene glycol, or plasticizers. 
     
     
         6 . The laminate construct of  claim 1 , wherein the second layer comprises an adhesive layer. 
     
     
         7 . The laminate construct of  claim 6 , wherein the adhesive layer comprises a pressure sensitive adhesive, a permanent adhesive, a light-activated adhesive or heat-activated adhesive, a natural polymer adhesive, or a synthetic polymer adhesive, a cross-linked polymeric adhesive, or a noncross-linked polymeric adhesive. 
     
     
         8 . The laminate construct of  claim 7 , wherein the adhesive polymer is polyurethane, silicone, casein, acrylic, polyisobutylene, polyacrylate, or stryrene. 
     
     
         9 . The laminate construct of  claim 1 , further comprising at least one structural element. 
     
     
         10 . The laminate construct of  claim 9 , wherein the structural element is a matrix material on which the antimicrobial layer has been formed. 
     
     
         11 . The laminate construct of  claim 10 , wherein the matrix material is a woven or nonwoven material. 
     
     
         12 . The laminate construct of  claim 9 , wherein the structural element is a liner. 
     
     
         13 . The laminate construct of  claim 12 , wherein there are two structural elements, each of which is a liner. 
     
     
         14 . The laminate construct of  claim 13 , wherein the two liners are the same material. 
     
     
         15 . The laminate construct of  claim 13 , wherein the two liners are different materials. 
     
     
         16 . The laminate construct of  claim 13 , wherein an antimicrobial layer is contacting one liner, and an adhesive layer is contacting the second liner. 
     
     
         17 . A method of making a laminate construct comprising,
 a. Applying an antimicrobial composition to a structural element to form a coating on the structural element;   b. Removing at least a portion of one or more solvents from the antimicrobial composition to form an antimicrobial layer;   c. Applying an adhesive composition to the outer surface of the antimicrobial layer;   d. Removing at least a portion of one or more solvents from the adhesive composition to form an adhesive layer; and   e. Optionally, adding a second structural element to cover the adhesive layer.   
     
     
         18 . The method of  claim 17 , wherein the antimicrobial layer comprises at least one antimicrobial agent comprising, an antibiotic, antiseptic, silver, silver salts, silver nanoparticles, ionic silver, combinations of one or more one silver compounds, zinc, copper, gold, and their salts, quaternary ammonium salts, isoniazid, ethambutol, pyrazinamide, streptomycin, clofazimine, rifabutin, fluoroquinolones, ofloxacin, sparfloxacin, rifampin, azithromycin, clarithromycin, dapsone, tetracycline, erythromycin, ciprofloxacin, doxycycline, ampicillin, amphotericin B, ketoconazole, fluconazole, pyrimethamine, sulfadiazine, clindamycin, lincomycin, pentamidine, atovaquone, paromomycin, diclazaril, acyclovir, trifluorouridine, foscarnet, penicillin, gentamicin, ganciclovir, iatroconazole, miconazole, Zn-pyrithione, chlorohexidine, polyhexamethylene biguanides, polyhexamethylene biguanides, triclosan, iodine, iodine-polyvinyl pyrrolidone complex, urea-peroxide complex, benzalkonium salts, turmeric extract, natural anti-infective compounds, or combinations thereof. 
     
     
         19 . The method of  claim 17 , wherein the antimicrobial layer further comprises one or more additives. 
     
     
         20 . An article comprising a laminate construct of  claim 1 .