Methods for treatment of dermatological conditions

Abstract

A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.

1 . A method for reducing the appearance of skin wrinkles, sagging in the eye area or jowls, frown lines, expression lines, striae, stretch marks, loss of skin elasticity, loss of skin tightness, loss of skin firmness, loss of skin recoil from deformation, loss of collagen and elastic fibers, comprising topically applying to affected skin areas a composition comprising at least one compound selected from bis[[(2-hydroxy-ethyl)-imino]diaceto]-cuprate (II), bis[[(2-hydroxy-ethyl)-imino]-diaceto]-zincate (II), bis[[(2-hydroxy-ethyl)-imino]-diaceto]-manganate (II), and isomers, racemic or non-racemic mixtures of isomers, or acceptable salts thereof. 
   
   
       2 . The method of  claim 1  comprising administering a composition comprising at least one compound selected from bis[[(2-hydroxy-ethyl)-imino]diaceto]-cuprate (II), bis[[(2-hydroxy-ethyl)-imino]-diaceto]-zincate (II), bis[[(2-hydroxy-ethyl)-imino]-diaceto]-manganate (II), and isomers, racemic or non-racemic mixtures of isomers, or acceptable salts thereof, with at least one cosmetically acceptable excipient. 
   
   
       3 . The method of  claim 1  wherein said treatment is for improving the appearance of loss of skin elasticity, skin tightness or skin firmness. 
   
   
       4 . The method of  claim 1  wherein said composition further comprises at least one additional benefit agent selected from sunscreens, retinoids, antioxidants, hydroxyacids, fatty acids, acceptable non-toxic organic salts of zinc, copper, or magnesium optionally derived from naturally occurring amino acids or from hydroxyalkyl acids, botanical extracts, salicylic acid, benzoyl peroxide, antibiotics, antiandrogens, anti-inflammatory agents, ascorbic acid, vitamins B, tocopherols or tocotrienols, corticosteroids, or mixtures thereof.