Pharmaceutical composition

Abstract

Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1) below, 50-95% by mass of an alcohol, and 0.1-35% by mass of water and/or an anionic surfactant.

1 . An antifungal agent for external use, comprising: 1) a compound represented by the general formula (1); 2) 50 to 95 mass % of an alcohol; and 3) 0.1 to 35 mass % of water and/or an anionic surfactant. 
     
       
         
         
             
             
         
       
     
   
   
       2 . The antifungal agent for external use according to  claim 1 , wherein the compound represented by the general formula (1) is luliconazole. 
   
   
       3 . The antifungal agent for external use according to  claim 1 , wherein the antifungal agent is in a form of a single-phase solution. 
   
   
       4 . The antifungal agent for external use according to  claim 1 , comprising substantially no flammable solvent excluding an alcohol. 
   
   
       5 - 6 . (canceled) 
   
   
       7 . A method for treating mycosis comprising administering transdermally to a subject in need thereof a composition comprising: 1) a compound represented by the general formula (1); 2) 50 to 95 mass % of an alcohol; and 3) 0.1 to 35 mass % of water and/or an anionic surfactant. 
     
       
         
         
             
             
         
       
     
   
   
       8 . The method according to  claim 7 , wherein the compound represented by the general formula (1) is luliconazole. 
   
   
       9 . The method according to  claim 7 , wherein the composition is in a form of a single-phase solution. 
   
   
       10 . The method according to  claim 7 , wherein the composition comprises substantially no flammable solvent excluding an alcohol. 
   
   
       11 . The method according to  claim 7 , wherein the mycosis is selected from the group consisting of tinea, candidiasis, chromophytosis, and seborrheic dermatitis. 
   
   
       12 . The method according to  claim 11 , wherein the micosis is seborrheic dermatitis. 
   
   
       13 . A method for stabilizing a compound represented by the general formula (1) in medicine comprising adding 1) 50 to 95 mass % of an alcohol; and 2) 0.1 to 35 mass % of water and/or an anionic surfactant to a pharmaceutical composition. 
   
   
       14 . The method according to  claim 13 , wherein the compound represented by the general formula (1) is luliconazole. 
   
   
       15 . The method according to  claim 13 , wherein the stabilizing effects are depletion of production of their isomers. 
   
   
       16 . The method according to  claim 15 , wherein the isomer(s) are E form and/or Z form of luliconazole.