US2010215749A1PendingUtilityA1

TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS

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Assignee: UNIV WASHINGTONPriority: Mar 16, 2006Filed: Apr 8, 2010Published: Aug 26, 2010
Est. expiryMar 16, 2026(expired)· nominal 20-yr term from priority
Inventors:Patrick S. StaytonAllan S. HoffmanXiangchun YinLakeshia J. TaiteJessica Garbern
C08F 220/54A61K 47/6903C08F 2810/20C08F 293/00C08F 2438/03C08L 53/00B82Y 5/00C08F 8/00A61K 47/6933A61K 47/58C08F 220/06C08F 2800/20C08L 2312/00A61K 47/6907C08F 220/04C08F 293/005
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Claims

Abstract

Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.

Claims

exact text as granted — not AI-modified
1 . A random copolymer, comprising:
 (a) temperature-responsive repeating units, wherein the repeating unit is an N-alkylacrylamide repeating unit; and   (b) pH-responsive repeating units, wherein the repeating unit is a C2-C8 alkylacrylic acid repeating unit.   
     
     
         2 . The copolymer of  claim 1 , wherein the copolymer exhibits a phase transition at a pH of from about pH 5.0 to about pH 7.4. 
     
     
         3 . The copolymer of  claim 1 , wherein the N-alkylacrylamide is a C3-C8 alkyl N-alkylacrylamide. 
     
     
         4 . The copolymer of  claim 1 , wherein the N-alkylacrylamide is N-isopropylacrylamide. 
     
     
         5 . The copolymer of  claim 1 , wherein the C2-C8 alkylacrylic acid is a C2-C8 n-alkylacrylic acid. 
     
     
         6 . The copolymer of  claim 1 , wherein the C2-C8 alkylacrylic acid is selected from the group consisting of ethylacrylic acid, n-propylacrylic acid, and n-butylacrylic acid. 
     
     
         7 . The copolymer of  claim 1 , wherein the C2-C8 alkylacrylic acid is n-propylacrylic acid. 
     
     
         8 . The copolymer of  claim 1 , wherein the pH-responsive repeating units are present in the copolymer in an amount from about 1 to about 50 weight percent. 
     
     
         9 . The copolymer of  claim 1 , wherein the N-alkylacrylamide is N-isopropylacrylamide and the alkylacrylic acid is propylacrylic acid. 
     
     
         10 . The copolymer of  claim 1  having a molecular weight of from about 5,000 to about 40,000. 
     
     
         11 . A hydrogel, comprising a crosslinked copolymer, wherein the copolymer comprises:
 (a) temperature-responsive repeating units, wherein the repeating unit is an N-alkylacrylamide repeating unit; and   (b) pH-responsive repeating units, wherein the repeating unit a C2-C8 alkylacrylic acid repeating unit.   
     
     
         12 . The hydrogel of  claim 11 , wherein the hydrogel exhibits a phase transition at a pH of from about pH 5.0 to about pH 7.4. 
     
     
         13 . The hydrogel of  claim 11 , wherein the N-alkylacrylamide is a C3-C8 alkyl N-alkylacrylamide. 
     
     
         14 . The hydrogel of  claim 11 , wherein the N-alkylacrylamide is N-isopropylacrylamide. 
     
     
         15 . The hydrogel of  claim 11 , wherein the C2-C8 alkylacrylic acid is a C2-C8 n-alkylacrylic acid. 
     
     
         16 . The hydrogel of  claim 11 , wherein the C2-C8 alkylacrylic acid is selected from the group consisting of ethylacrylic acid, n-propylacrylic acid, and n-butylacrylic acid. 
     
     
         17 . The hydrogel of  claim 11 , wherein the C2-C8 alkylacrylic acid is n-propylacrylic acid. 
     
     
         18 . The hydrogel of  claim 11 , wherein the pH-responsive repeating units are present in the copolymer in an amount from about 1 to about 50 weight percent. 
     
     
         19 . The hydrogel of  claim 11 , wherein the N-alkylacrylamide repeating unit is N-isopropylacrylamide and the alkylacrylic acid is propylacrylic acid. 
     
     
         20 . The hydrogel of  claim 11  further comprising a therapeutic or diagnostic agent. 
     
     
         21 . The hydrogel of  claim 20 , wherein the therapeutic drug or diagnostic agent is selected from the group consisting of a protein, a peptide, and a nucleic acid. 
     
     
         22 . The hydrogel of  claim 11  further comprising a sugar. 
     
     
         23 . A drug delivery device, comprising the copolymer of  claim 1  and a therapeutic drug or diagnostic agent. 
     
     
         24 . A drug delivery device, comprising the hydrogel of  claim 11  and a therapeutic drug or diagnostic agent. 
     
     
         25 . A conjugate, comprising the copolymer of  claim 1  and a therapeutic drug or diagnostic agent. 
     
     
         26 . A conjugate, comprising the hydrogel of  claim 11  and a therapeutic drug or diagnostic agent. 
     
     
         27 . A modified nanoparticle, comprising the copolymer of  claim 1  attached to a nanoparticle. 
     
     
         28 . The modified nanoparticle of  claim 27  further comprising a therapeutic drug or diagnostic agent. 
     
     
         29 . A modified nanoparticle, comprising the hydrogel of  claim 11  attached to a nanoparticle. 
     
     
         30 . The modified nanoparticle of  claim 29  further comprising a therapeutic drug or diagnostic agent.

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