Methods and compositions for treating acne

Abstract

A method for treating acne on the skin. The method has the steps of (a) providing an drapeable or flexible porous article impregnated with an aqueous cleansing composition having a carrier, benzoyl peroxide, and one or more cleansing agents; (b) contacting an area of the skin affected by acne with the porous article such that the skin is contacted by the composition; and (c) removing the composition from the skin wherein residual benzoyl peroxide remains on the skin in an anti-acne effective amount. There are also anti-acne compositions.

1 . An anti-acne composition, comprising:
 (a) water;   (b) benzoyl peroxide;   (c) a thickening agent comprising carbomer 1342 or Pemulen TR-1, hydroxypropyl methylcellulose, and cetyl alcohol;   (d) a cleansing agent component comprising sodium methyl cocoyl taurate and sodium cocoyl isethionate in an amount sufficient to render the composition foamable and to maintain a substantially homogeneous dispersion of the benzoyl peroxide in the composition;   (e) glycolic acid; and   (f) and zinc lactate.   
     
     
         2 . An anti-acne composition, comprising:
 (a) water;   (b) benzoyl peroxide;   (c) a salt of a fatty acid ester having from 12 to 20 carbon atoms; and   (d) a salt of a fatty acid isethionate having from 12 to 20 carbon atoms,   wherein the salt of a fatty acid ester and the salt of a fatty acid isethionate are present in an amount sufficient to render the composition foamable and to maintain a substantially homogeneous dispersion of the benzoyl peroxide in the composition.   
     
     
         3 . The composition of  claim 2 , wherein the salt of a fatty acid ester is sodium methyl cocoyl taurate. 
     
     
         4 . The composition of  claim 2 , wherein the salt of a fatty acid isethionate is sodium cocoyl isethionate. 
     
     
         5 . The composition of  claim 2 , wherein the salt of a fatty acid ester and the salt of a fatty acid isethionate are present at a total of about 8 to about 30 wt % based on the total weight of the composition. 
     
     
         6 . The composition of  claim 2 , further comprising a salt of a fatty acid sulfoacetate having from 12 to 20 carbons and a disalt of a fatty acid sulfosuccinate having from 12 to 20 carbons. 
     
     
         7 . The composition of  claim 6 , wherein the salt of a fatty acid sulfoacetate is sodium lauryl sulfoacetate and the disalt of a fatty acid sulfosuccinate is disodium laureth sulfosuccinate. 
     
     
         8 . The composition of  claim 6 , wherein the salt of a fatty acid sulfoacetate and the disalt of a fatty acid sulfosuccinate are present at a total of about 1 to about 10 wt % based on the total weight of the composition. 
     
     
         9 . An anti-acne composition, comprising:
 (a) water;   (b) benzoyl peroxide;   (c) a cellulose ether; and   (d) a polyacrylic polymer,   wherein the cellulose ether and the polyacrylic polymer are present in an amount sufficient to impart stability to the composition.   
     
     
         10 . The composition of  claim 9 , further comprising an additional ingredient selected from the group consisting of a fatty alcohol of 10 to 24 carbon atoms, a fatty acid of 10 to 24 carbon atoms, a fatty ester of 10 to 24 carbon atoms, an organic wax, chitosan, carrageenan, colloidal silicon dioxide, hydroxypropyl starch, kaolin, polycarbophil, propylene glycol alginate, sodium alginate, alginic acid, tragacanth, acacia, and trehalose, and any combination of the foregoing, wherein the cellulose ether, the polyacrylic polymer, and the additional ingredient are present in an amount sufficient to impart stability to the composition. 
     
     
         11 . The composition of  claim 9 , wherein the cellulose ether is present from about 0.1 wt % to about 3 wt % and the polyacrylic polymer is present from about 0.1 wt % to about 3 wt %. 
     
     
         12 . The composition of  claim 11 , wherein the cellulose ether is present from about 0.1 wt % to about 3 wt %, the polyacrylic polymer is present from about 0.1 wt % to about 3 wt %, and the additional ingredient is present from about 0.5 wt % to about 10 wt %. 
     
     
         13 . The composition of  claim 12 , wherein the additional ingredient is a fatty alcohol, wherein the fatty alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, cetearyl alcohol, myristyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, oleyl alcohol, erucyl alcohol, and any combination of the foregoing. 
     
     
         14 . The composition of  claim 10 , wherein the additional ingredient is the fatty alcohol of 10 to 24 carbon atoms, and wherein the fatty alcohol of 10 to 24 carbon atoms is cetyl alcohol. 
     
     
         15 . The composition of  claim 10 , wherein the additional ingredient is an organic wax, wherein the organic wax is selected from the group consisting of an emulsifying wax (nonionic emulsifying wax), an anionic emulsifying wax, a cetyl ester wax, a microcrystalline wax, a white wax, a yellow wax, paraffin, and any combination of the foregoing. 
     
     
         16 . The composition of  claim 9 , wherein the cellulose ether is selected from the group consisting of carboxymethylcellulose sodium, carboxymethylcellulose calcium, hydroxypropyl cellulose, hydroxyethylmethyl cellulose, ethylcellulose, hydroxyethylcellulose, methylcellulose, hydroxypropylcellulose, and hydroxypropylmethylcellulose. 
     
     
         17 . The composition of  claim 16 , wherein the cellulose ether is hydroxypropylmethylcellulose. 
     
     
         18 . The composition of  claim 9 , wherein the polyacrylic polymer is a carbomer. 
     
     
         19 . The composition of  claim 18 , wherein the carbomer is selected from the group consisting of Carbopol 1342, Carbopol 940, Carbopol 941, Carbopol 980, Carbopol 981, Carbopol 1382, Carbopol 971P, Carbopol 974P, Carbopol 71G, Carbopol 910, Carbopol 934, Carbopol 934P, Carbopol 5984, Carbopol ETD, Carbopol Ultrez 10, Carbopol Ultrez 21, Pemulen TR-1, Pemulen TR-2, and any combination of the foregoing. 
     
     
         20 . A method for treating acne on the skin, comprising:
 (a) providing a flexible porous article impregnated with a cleansing composition having a carrier, benzoyl peroxide, and one or more cleansing agents selected from sodium methyl cocoyl taurate, sodium cocoyl isethionate, and mixtures thereof;   (b) contacting an area of the skin affected by acne with the porous article such that the skin is contacted by the composition; and   (c) removing the composition from the skin wherein residual benzoyl peroxide remains on the skin in an anti-acne effective amount.   
     
     
         21 . A method for treating acne on the skin, comprising:
 (d) providing a flexible porous article impregnated with a cleansing composition having a carrier, benzoyl peroxide, and one or more cleansing agents;   (e) contacting an area of the skin affected by acne with the porous article such that the skin is contacted by the composition; and   (f) removing the composition from the skin wherein residual benzoyl peroxide remains on the skin in an anti-acne effective amount.   
     
     
         22 . The method of  claim 21 , wherein the contacting of the skin with the porous article is carried out by rubbing the skin with the porous article. 
     
     
         23 . The method of  claim 21 , wherein the contacting of the skin with the porous article results in lathering of the composition on the skin. 
     
     
         24 . The method of  claim 21 , wherein the composition is removed from the skin by rinsing. 
     
     
         25 . The method of  claim 24 , wherein the rinsing is with water. 
     
     
         26 . The method of  claim 21 , wherein the composition is removed from the skin by wiping. 
     
     
         27 . The method of  claim 21 , wherein the wiping is with a wet towel or cloth. 
     
     
         28 . The method of  claim 21 , wherein the wiping is with a dry towel or cloth or with the flexible porous article. 
     
     
         29 . The method of  claim 21 , wherein the absorbent porous article is a non-woven fabric or cloth article. 
     
     
         30 . The method of  claim 21 , wherein one or more cleansing agents is one or more surfactants. 
     
     
         31 . The method of  claim 21 , wherein the one or more surfactants is present from about 4 wt % to about 40 wt % of the total composition. 
     
     
         32 . The method of  claim 21 , wherein the one or more surfactants is one or more anionic surfactants. 
     
     
         33 . The method of  claim 32 , wherein the one or more anionic surfactants is selected from the group consisting of sodium lauryl sulfoacetate, disodium laureth sulfosuccinate, lauramine oxide, cocamidopropyl betaine, lauramidopropyl betaine, lauryl sulfoacetate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, and any combination thereof. 
     
     
         34 . The method of  claim 33 , wherein the one or more surfactants is selected from the group consisting of sodium lauryl sulfoacetate, disodium laureth sulfosuccinate, lauramine oxide, lauryl sulfoacetate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, and any combination thereof. 
     
     
         35 . The method of  claim 21 , wherein the benzoyl peroxide is present in the composition in an amount of about 1 wt % to about 15 wt % based on the total weight of the composition. 
     
     
         36 . The method of  claim 21 , wherein the benzoyl peroxide is present in the composition in an amount of about 3 wt % to about 9 wt % based on the total weight of the composition. 
     
     
         37 . The method of  claim 21 , wherein the composition further has one or more moisturizers. 
     
     
         38 . The method of  claim 21 , wherein the composition further has one or more zinc compounds. 
     
     
         39 . The method of  claim 21 , wherein the composition is aqueous. 
     
     
         40 . The method of  claim 21 , wherein the composition is nonaqueous. 
     
     
         41 . The method of  claim 21 , wherein the composition is an emulsion. 
     
     
         42 . The method of  claim 21 , wherein the composition is a suspension. 
     
     
         43 . The method of  claim 21 , wherein the composition is a dispersion. 
     
     
         44 . The method of  claim 21 , wherein the area of the skin affected by acne is the face. 
     
     
         45 . The method of  claim 21 , wherein the porous article is a cloth article.