Pendant fatty acid imaging agents

Abstract

The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.

1 . An imaging agent represented by the structure 1: 
       
         
           
           
               
               
           
         
       
       wherein
 R 1 , R 4 , R 5 , and R 6  are each independently selected from an alkyl, alkenyl or a bond; 
 R 2  is selected from the group consisting of a hydrogen, a primary amine, a secondary amine, a tertiary amine, an alkyl group, a substituted alkyl group, an aryl group, and a substituted aryl group; 
 R 3  is selected from the group consisting of a hydrogen, an alkyl, a hydroxyl, a keto ester, an alkoxy, a halide, and an amine; 
 R 7  is selected from a metal chelating moiety bound to a metallic carbonyl ligand; wherein the stereochemical configuration of a compound represented by 1 may be R, S, at the stereocenters; or a mixture of these configurations, and 
 the pharmaceutically acceptable salts, esters, amide's, and prodrugs thereof.