Ophthalmic composition containing alginic acid or salt thereof

Abstract

An ophthalmic composition that, despite containing alginic acid and/or a salt thereof, has improved tackiness during use and provides a satisfactory use feeling. The composition has an improved ability to remain on the eye mucosa. The ophthalmic composition contains (A) alginic acid and/or a salt thereof in combination with (B) hyaluronic acid and/or a salt thereof.

1 . An ophthalmic composition comprising Component (A) at least one member selected from the group consisting of alginic acid and salts thereof, and Component (B) at least one member selected from the group consisting of hyaluronic acid and salts thereof. 
   
   
       2 . The ophthalmic composition according to  claim 1 , which contains Component (B) in a ratio of 0.3 to 6,000 parts by weight per 100 parts by weight of Component (A). 
   
   
       3 . The ophthalmic composition according to  claim 1 , which contains Component (A) in a total amount of 0.001 to 5% by weight based on a total weight of the ophthalmic composition. 
   
   
       4 . The ophthalmic composition according to  claim 1 , which contains Component (B) in a total amount of 0.0001 to 2% by weight based on a total weight of the ophthalmic composition. 
   
   
       5 . The ophthalmic composition according to  claim 1 , which is an eye drop, an eye wash, or a wetting and rewetting drop for a contact lens. 
   
   
       6 . The ophthalmic composition according to  claim 1 , which is an ophthalmic composition for a soft contact lens. 
   
   
       7 . A method for improving the retention of an ophthalmic composition on an ocular mucosa, which comprises the step of mixing Component (B) at least one member selected from the group consisting of hyaluronic acid and salts thereof with an ophthalmic composition that contains Component (A) at least one member selected from the group consisting of alginic acid and salts thereof. 
   
   
       8 . A method for reducing the adsorption, to a soft contact lens, of at least one member selected from the group consisting of alginic acid and salts thereof, which comprises the step of mixing Component (B) at least one member selected from the group consisting of hyaluronic acid and salts thereof with an ophthalmic composition for a soft contact lens that contains Component (A) at least one member selected from the group consisting of alginic acid and salts thereof. 
   
   
       9 . A method for suppressing the adsorption, to a soft contact lens, of at least one member selected from the group consisting of alginic acid and salts thereof, which comprises the step of contacting the ophthalmic composition of  claim 6  with a soft contact lens. 
   
   
       10 . The method according to  claim 9 , which is a method for suppressing the adsorption, to a soft contact lens, of at least one member selected from the group consisting of alginic acid and salts thereof when administered as an eye drop or washing an eye, and the method comprises the step of applying the ophthalmic composition of  claim 6  to an eye wearing a soft contact lens. 
   
   
       11 . A method for retaining an ophthalmic composition on an ocular mucosa, which comprises the step of applying the ophthalmic composition of  claim 1  to an eye. 
   
   
       12 . The use of Component (A) at least one member selected from the group consisting of alginic acid and salts thereof, and Component (B) at least one member selected from the group consisting of hyaluronic acid and salts thereof for the manufacture of an ophthalmic composition.