Multi component non-woven

Abstract

The formation of a non-woven, free from organic solvent, formed through parallel formation of fibers on a collection device is disclosed. As the individual fibers are dry prior to contact with other fibers, the different contents of the various fiber types do not interact. However, when wetted, the fibers will start to be dissolved, or swell, and the different contents will be released and then interact. For the example of thrombin and fibrinogen, the interaction will initiate the formation of a fibrin coagulum by the cleavage of fibrinogen through the action of thrombin to form fibrin monomers that spontaneously polymerize to form a three dimensional network of fibrin.

1 . Multi component non-woven of fibers of a natural, water dissolvable protein structure, comprising at least two fiber types of different compositions. 
     
     
         2 . Multi component non-woven according to  claim 1 , wherein the different compositions constitute different contents of active substance. 
     
     
         3 . Multi component non-woven according to  claim 1 , wherein the active substance is distributed homogeniously throughout the fiber. 
     
     
         4 . Multi component non-woven according to  claim 1 , wherein natural protein structure is biodegradable. 
     
     
         5 . Multi component non-woven according to  claim 1 , wherein the natural protein structure is selected from the group consisting of keratin, collagen, and gelatin. 
     
     
         6 . Multi component non-woven according to  claim 1 , wherein particles are suspended in at least one of the fiber compositions. 
     
     
         7 . Multi component non-woven according to  claim 1 , wherein the particles have a mean diameter wider than the mean diameter of the fibers. 
     
     
         8 . Multi component non-woven according to  claim 1 , wherein the particles are ECM particles. 
     
     
         9 . Multi component non-woven according to  claim 1 , wherein at least one of the fiber compositions comprises thrombin and at least one other fiber composition comprises fibrinogen. 
     
     
         10 . Multi component non-woven according to  claim 1 , wherein the non-woven is cross-linked. 
     
     
         11 . Multi component non-woven according to  claim 1 , wherein at least one of the fiber compositions further comprises a polycarboxylic acid. 
     
     
         12 . Multi component non-woven according to  claim 1 , wherein at least one of the fiber compositions has a larger diameter than at least one other.