Motuporamine Mimic Agents

Abstract

Disclosed herein are motuporamine mimic agents and methods of making and using same. Particularly exemplified are motuporamine mimic agents comprising cytotoxic activity and/or anti-metaplastic activity.

1 . A pharmaceutical composition comprising a therapeutic compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic compound comprises the following Formula I: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A compound useful in cancer therapy, said compound comprising the following formula, including a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound of  claim 2 , wherein one or both of the hydrogens of the amino tail are substituted with a linear alkyl (methyl, ethyl, propyl, butyl, pentyl or hexyl) or branched alkyl (isopropyl, isobutyl, sec-butyl or t-butyl), or alkylaryl (wherein the aryl ring is either a benzene, naphthalene, anthracene or pyrene ring system and the alkyl chain length is either methylene, ethylene, propylene, butylene, pentylene or hexylene) 
     
     
         4 . A pharmaceutical composition useful in cancer therapy wherein said composition comprises one or more compounds of Formula II, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein Formula II is: 
       
         
           
           
               
               
           
         
         wherein R is alkylaryl (wherein the aryl ring is either a benzene, naphthalene, anthracene or pyrene ring system and the alkyl chain length is either methylene, ethylene, propylene, butylene, pentylene or hexylene), alkyl, or cycloalkyl; 
         R 1  is hydrogen, linear alkyl (methyl, ethyl, propyl, butyl, pentyl or hexyl) or branched alkyl (isopropyl, isobutyl, sec-butyl or t-butyl), or alkylaryl (wherein the aryl ring is either a benzene, naphthalene, anthracene or pyrene ring system and the alkyl chain length is either methylene, ethylene, propylene, butylene, pentylene or hexylene); 
         R 2  is hydrogen, alkyl, alkylaryl, aryl or (CH2)yR 3    
         R 3  is alkylamido, amino, aminoalkyl, N-alkyl, N-alkylamido, or Nalkylaryl,N-alkyl amino; and 
         x=4 and y=4.