N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use

Abstract

The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine. Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.

1 . A composition comprising an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form for topical or systemic administration to a mammalian subject for treatment of cosmetic conditions or dermatological disorders;
 wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is N-(phosphonoalkyl)-proline or has the following formula:
   R 1 CH(NR 2 R 3 )(CH 2 ) m COR 4    
   
     wherein R 1  is H, an alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and R 1  can also carry —OH, —SH, —SCH 3 , —NH 2 , —NR 2 R 3 , —COR 4 , —NHCONH 2 , —NHC(=NR 2 )NH 2 , imidazole, pyrrolidine or other heterocyclic group; m is an integer from 0 to 5; R 2  is a phosphonoalkyl group having a formula (HO) 2 PO(CH 2 ) n —; R 3  is H or a phosphonoalkyl group having a formula (HO) 2 PO(CH 2 ) n —; n is an integer from 1 to 9; R 4  is —NH 2  or —OR 5 , R 5  is H, an alkyl group having 1 to 19 carbon atoms, an aryl group having 6 to 19 carbon atoms or an aralkyl group having 7 to 19 carbon atoms; and the H attached to any carbon atom can be substituted by I, F, Cl, Br, OH or an alkoxy group having 1 to 9 carbon atoms; and
 wherein the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof is in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form. 
 
   
   
       2 . The composition of  claim 1 , wherein the related compound or derivative in amide form is an N,N-bis(phosphonoalkyl)-aminoamide or an N,N′-bis(phosphonoalkyl)-aminoamide. 
   
   
       3 . The composition of  claim 1 , wherein the related compound or derivative is an N,N-bis(phosphonomethyl)-aminoamide or an N,N′-bis(phosphonomethyl)-aminoamide. 
   
   
       4 . The composition of  claim 3 , wherein the N,N-bis(phosphonomethyl)-aminoamide or N,N′-bis(phosphonomethyl)-aminoamide in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of
 N,N-bis(phosphonomethyl)-alanine amide; N,N-bis(phosphonomethyl)-arginine amide; N,N-bis(phosphonomethyl)-aspartic diamide; N,N-bis(phosphonomethyl)-asparagine amide; N,N-bis(phosphonomethyl)-cysteine amide; N,N-bis(phosphonomethyl)-glycine amide; N,N-bis(phosphonomethyl)-glutamic diamide; N,N-bis(phosphonomethyl)-glutamine amide; N,N-bis(phosphonomethyl)-histidine amide; N,N-bis(phosphonomethyl)-isoleucine amide; N,N-bis(phosphonomethyl)-leucine amide; N,N-bis(phosphonomethyl)-lysine amide; N,N-bis(phosphonomethyl)-methionine amide; N,N-bis(phosphonomethyl)-phenylalanine amide; N,N-bis(phosphonomethyl)-serine amide; N,N-bis(phosphonomethyl)-threonine amide; N,N-bis(phosphonomethyl)-tryptophan amide; N,N-bis(phosphonomethyl)-tyrosine amide; N,N-bis(phosphonomethyl)-valine amide; N,N′-bis(phosphonomethyl)-arginine amide; N,N′/-bis(phosphonomethyl)-histidine amide; N,N′-bis(phosphonomethyl)-lysine amide and N,N′-bis(phosphonomethyl)-tryptophan amide.   
   
   
       5 . The composition of  claim 3 , wherein the related compound or compound derived thereof in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N,N-bis(phosphonomethyl)-β-alanine amide; N,N-bis(phosphonomethyl)-γ-aminobutanoic amide; N,N-bis(phosphonomethyl)-β-aminoisobutanoic amide; N,N-bis(phosphonomethyl)-anserine amide; N,N-bis(phosphonomethyl)-aminolevulinic amide; N,N-bis(phosphonomethyl)-carnosine amide; N,N-bis(phosphonomethyl)-canaline amide; N,N-bis(phosphonomethyl)-canavanine amide; N,N-bis(phosphonomethyl)-citrulline amide; N,N-bis(phosphonomethyl)-creatine amide; N,N-bis(phosphonomethyl)-cysteine sulfinic amide; N,N-bis(phosphonomethyl)-cystine amide; N,N-bis(phosphonomethyl)-dopa amide {N,N bis(phosphonomethyl)-3,4-dihydroxyphenylalanine amide}; N,N-bis(phosphonomethyl)-ethionine amide; N,N-bis(phosphonomethyl)-glutathione amide; N,N-bis(phosphonomethyl)-guanidinoacetic amide; N,N-bis(phosphonomethyl)-3-guanidinopropanoic amide; N,N-bis(phosphonomethyl)-4-guanidinobutanoic amide; N,N-bis(phosphonomethyl)-homocarnosine amide; N,N-bis(phosphonomethyl)-homocysteine amide; N,N-bis(phosphonomethyl)-homoserine amide; N,N-bis(phosphonomethyl)-4-hydroxyphenylglycine amide; N,N-bis(phosphonomethyl)-hydroxyglutamic amide; N,N-bis(phosphonomethyl)-hydroxylysine amide; N,N-bis(phosphonomethyl)-hydroxyproline amide; N,N-bis(phosphonomethyl)-hypusine amide; N,N-bis(phosphonomethyl)-homoarginine amide; N,N-bis(phosphonomethyl)-homocitrulline amide; N,N-bis(phosphonomethyl)-homocystine amide; N,N-bis(phosphonomethyl)-homophenylalanine amide; N,N-bis(phosphonomethyl)-homotryptophan amide; N,N-bis(phosphonomethyl)-hydroxylysine amide; N,N-bis(phosphonomethyl)-hydroxyarginine amide; N,N-bis(phosphonomethyl)-hydroxyhomoarginine amide; N,N-bis(phosphonomethyl)-hydroxycitrulline amide; N,N-bis(phosphonomethyl)-hydroxyornithine amide; N,N-bis(phosphonomethyl)-hydroxyvaline amide; N,N-bis(phosphonomethyl)-methoxinine amide; N,N-bis(phosphonomethyl)-methylarginine amide; N,N-bis(phosphonomethyl)-methylhistidine amide; N,N-bis(phosphonomethyl)-methyllysine amide; N,N-bis(phosphonomethyl)-methylornithine amide; N,N-bis(phosphonomethyl)-methylserine amide; N,N-bis(phosphonomethyl)-norvaline amide; N,N-bis(phosphonomethyl)-ornithine amide; N,N-bis(phosphonomethyl)-oxalysine amide; N,N-bis(phosphonomethyl)-penicillamine amide(N-phosphonomethyl-dimethylcysteine amide); N,N-bis(phosphonomethyl)-phenylglycine amide; N,N-bis(phosphonomethyl)-3-phenylserine amide; N,N-bis(phosphonomethyl)-sarcosine amide (N-phosphonomethyl-N-methyl-glycine amide); N,N-bis(phosphonomethyl)-taurine amide; and N,N′-bis(phosphonomethyl)-ornithine amide. 
   
   
       6 . The composition of  claim 1 , wherein the phosphonoalkyl of the N-(phosphonoalkyl)-amino acid compound, related compound or compound derived thereof is selected from the group consisting of phosphonomethyl, phosphonoethyl, phosphonopropyl, phosphonoisopropyl, phosphonobutyl, phosphonoisobutyl, phosphonopentyl, phosphonoisopentyl, phosphonooctyl and phosphonoisooctyl. 
   
   
       7 . The composition of  claim 1 , wherein the compound in amide form is an N-(phosphonoalkyl)-aminoamide. 
   
   
       8 . The composition of  claim 1 , wherein the compound in amide form is an N-(phosphonomethyl)-aminoamide. 
   
   
       9 . The composition of  claim 8 , wherein the N-(phosphonomethyl)-aminoamide in a form as a free acid, salt, amide or ester, or in a stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-alanine amide, N-(phosphonomethyl)-arginine amide, N-(phosphonomethyl)-asparagine amide, N-(phosphonomethyl)-aspartic diamide, N-(phosphonomethyl)-cysteine amide, N-(phosphonomethyl)-glutamic diamide, N-(phosphonomethyl)-glutamine amide, N-(phosphonomethyl)-glycine amide, N-(phosphonomethyl)-histidine amide, N-(phosphonomethyl)-isoleucine amide, N-(phosphonomethyl)-leucine amide, N-(phosphonomethyl)-lysine amide, N-(phosphonomethyl)-methionine amide, N-(phosphonomethyl)-phenylalanine amide, N-(phosphonomethyl)-proline amide, N-(phosphonomethyl)-serine amide, N-(phosphonomethyl)-threonine amide, N-(phosphonomethyl)-tryptophan amide, N-(phosphonomethyl)-tyrosine amide and N-(phosphonomethyl)-valine amide. 
   
   
       10 . The composition of  claim 1 , wherein the N-(phosphonoalkyl)-amino acid compound, related compound or compound derived thereof in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-β-alanine amide; N-(phosphonomethyl)-γ-aminobutanoic amide; N-(phosphonomethyl)-β-aminoisobutanoic amide; N-(phosphonomethyl)-anserine amide; N-(phosphonomethyl)-aminolevulinic amide; N-(pho sphonomethyl)-carnosine amide; N-(phosphonomethyl)-canaline amide; N-(phosphonomethyl)-canavanine amide; N-(phosphonomethyl)-citrulline amide; N-(phosphonomethyl)-creatine amide; N-(phosphonomethyl)-cysteine sulfinic amide; N-(phosphonomethyl)-cystine amide; N-(phosphonomethyl)-dopa amide{N,N bis(phosphonomethyl)-3,4-dihydroxyphenylalanine amide}; N-(phosphonomethyl)-ethionine amide; N-(phosphonomethyl)-glutathione amide; N-(phosphonomethyl)-guanidinoacetic amide; N-(phosphonomethyl)-3-guanidinopropanoic amide; N-(phosphonomethyl)-4-guanidinobutanoic amide; N-(phosphonomethyl)-homocarnosine amide; N-(phosphonomethyl)-homocysteine amide; N-(phosphonomethyl)-homoserine amide; N-(phosphonomethyl)-4-hydroxyphenylglycine amide; N-(phosphonomethyl)-hydroxyglutamic diamide; N-(phosphonomethyl)-hydroxylysine amide; N-(phosphonomethyl)-hydroxyproline amide; N-(phosphonomethyl)-hypusine amide; N-(phosphonomethyl)-homoarginine amide; N-(phosphonomethyl)-homocitrulline amide; N-(phosphonomethyl)-homocystine amide; N-(phosphonomethyl)-homophenylalanine amide; N-(phosphonomethyl)-homotryptophan amide; N-(phosphonomethyl)-hydroxylysine amide; N-(phosphonomethyl)-hydroxyarginine amide; N-(phosphonomethyl)-hydroxyhomoarginine amide; N-(phosphonomethyl)-hydroxycitrulline amide; N-(phosphonomethyl)-hydroxyornithine amide; N-(phosphonomethyl)-hydroxyvaline amide; N-(phosphonomethyl)-methoxinine amide; N-(phosphonomethyl)-methylarginine amide; N-(phosphonomethyl)-methylhistidine amide; N-(phosphonomethyl)-methyllysine amide; N-(phosphonomethyl)-methylornithine amide; N-(phosphonomethyl)-methylserine amide; N-(phosphonomethyl)-norvaline amide; N-(phosphonomethyl)-ornithine amide; N-(phosphonomethyl)-oxalysine amide; N-(phosphonomethyl)-penicillamine amide(N-phosphonomethyl-dimethylcysteine amide); N-(phosphonomethyl)-phenylglycine amide; N-(phosphonomethyl)-3-phenylserine amide; N-(phosphonomethyl)-sarcosine amide (N-phosphonomethyl-N-methyl-glycine amide); N-(phosphonomethyl)-taurine amide; and N-(phosphonomethyl)-ornithine amide. 
   
   
       11 . The composition of  claim 1 , wherein the compound in ester form is an N-(phosphonoalkyl)-amino ester. 
   
   
       12 . The composition of  claim 1 , wherein the compound in ester form is an N-(phosphonomethyl)-amino ester. 
   
   
       13 . The composition of  claim 12 , wherein the N-(phosphonomethyl)-amino ester in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-alanine ester, N-(phosphonomethyl)-arginine ester, N-(phosphonomethyl)-asparagine ester, N-(phosphonomethyl)-aspartic diester, N-(phosphonomethyl)-cysteine ester, N-(phosphonomethyl)-glutamic diester, N-(phosphonomethyl)-glutamine ester, N-(phosphonomethyl)-glycine ester, N-(phosphonomethyl)-histidine ester, N-(phosphonomethyl)-isoleucine ester, N-(phosphonomethyl)-leucine ester, N-(phosphonomethyl)-lysine ester, N-(phosphonomethyl)-methionine ester, N-(phosphonomethyl)-phenylalanine ester, N-(phosphonomethyl)-proline ester, N-(phosphonomethyl)-serine ester, N-(phosphonomethyl)-threonine ester, N-(phosphonomethyl)-tryptophan ester, N-(phosphonomethyl)-tyrosine ester and N-(phosphonomethyl)-valine ester. 
   
   
       14 . The composition of  claim 12 , wherein the N-(phosphonomethyl)-amino ester, related compound or compound derived thereof in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(phosphonomethyl)-β-alanine ester; N-(phosphonomethyl)-γ-aminobutanoic ester; N-(phosphonomethyl)-β-aminoisobutanoic ester; N-(phosphonomethyl)-anserine ester; N-(phosphonomethyl)-aminolevulinic ester; N-(phosphonomethyl)-carnosine ester; N-(phosphonomethyl)-canaline ester; N-(phosphonomethyl)-canavanine ester; N-(phosphonomethyl)-citrulline ester; N-(phosphonomethyl)-creatine ester; N-(phosphonomethyl)-cysteine sulfinic ester; N-(phosphonomethyl)-cystine ester; N-(phosphonomethyl)-dopa ester{N,N bis(phosphonomethyl)-3,4-dihydroxyphenylalanine ester}; N-(phosphonomethyl)-ethionine ester; N-(phosphonomethyl)-glutathione ester; N-(phosphonomethyl)-guanidinoacetic ester; N-(phosphonomethyl)-3-guanidinopropanoic ester; N-(phosphonomethyl)-4-guanidinobutanoic ester; N-(phosphonomethyl)-homocarnosine ester; N-(phosphonomethyl)-homocysteine ester; N-(phosphonomethyl)-homoserine ester; N-(phosphonomethyl)-4-hydroxyphenylglycine ester; N-(phosphonomethyl)-hydroxyglutamic diester; N-(phosphonomethyl)-hydroxylysine ester; N-(phosphonomethyl)-hydroxyproline ester; N-(phosphonomethyl)-hypusine ester; N-(phosphonomethyl)-homoarginine ester; N-(phosphonomethyl)-homocitrulline ester; N-(phosphonomethyl)-homocystine ester; N-(phosphonomethyl)-homophenylalanine ester; N-(phosphonomethyl)-homotryptophan ester; N-(phosphonomethyl)-hydroxylysine ester; N-(phosphonomethyl)-hydroxyarginine ester; N-(phosphonomethyl)-hydroxyhomoarginine ester; N-(phosphonomethyl)-hydroxycitrulline ester; N-(phosphonomethyl)-hydroxyornithine ester; N-(phosphonomethyl)-hydroxyvaline ester; N-(phosphonomethyl)-methoxinine ester; N-(phosphonomethyl)-methylarginine ester; N-(phosphonomethyl)-methylhistidine ester; N-(phosphonomethyl)-methyllysine ester; N-(phosphonomethyl)-methylornithine ester; N-(phosphonomethyl)-methylserine ester; N-(phosphonomethyl)-norvaline ester; N-(phosphonomethyl)-ornithine ester; N-(phosphonomethyl)-oxalysine ester; N-(phosphonomethyl)-penicillamine ester(N-phosphonomethyl-dimethylcysteine ester); N-(phosphonomethyl)-phenylglycine ester; N-(phosphonomethyl)-3-phenylserine ester; N-(phosphonomethyl)-sarcosine ester (N-phosphonomethyl-N-methyl-glycine ester); N-(phosphonomethyl)-taurine ester; and N-(phosphonomethyl)-ornithine ester. 
   
   
       15 . The composition of  claim 1 , wherein the compound in ester form is an N-(O,O′-dialkylphosphonomethyl)-amino acid. 
   
   
       16 . The composition of  claim 15 , wherein the N-(O,O′-dialkylphosphonomethyl)-amino acid is N-(O,O′-diethylphosphonomethyl)-amino acid. 
   
   
       17 . The composition of  claim 16 , wherein the N-(O,O′-diethylphosphonomethyl)-amino acid in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-alanine; N-(O,O′-diethylphosphonomethyl)-arginine; N-(O,O′-diethylphosphonomethyl)-asparagine; N-(O,O′-diethylphosphonomethyl)-aspartic acid; N-(O,O′-diethylphosphonomethyl)-cysteine; N-(O,O′-diethylphosphonomethyl)-glutamic acid, N-(O,O′-diethylphosphonomethyl)-glutamine; N-(O,O′-diethylphosphonomethyl)-glycine; N-(O,O′-diethylphosphonomethyl)-histidine; N-(O,O′-diethylphosphonomethyl)-isoleucine; N-(O,O′-diethylphosphonomethyl)-leucine; N-(O,O′-diethylphosphonomethyl)-lysine; N-(O,O′-diethylphosphonomethyl)-methionine; N-(O,O′-diethylphosphonomethyl)-phenylalanine; N-(O,O′-diethylphosphonomethyl)-proline; N-(O,O′-diethylphosphonomethyl)-serine; N-(O,O′-diethylphosphonomethyl)-threonine; N-(O,O′-diethylphosphonomethyl)-tryptophan; N-(O,O′-diethylphosphonomethyl)-tyrosine and N-(O,O′-diethylphosphonomethyl)-valine. 
   
   
       18 . The composition of  claim 16 , wherein the N-(O,O′-diethylphosphonomethyl)-amino acid, related compound or compound derived thereof in a form as a free acid, salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-β-alanine; N-(O,O′-diethylphosphonomethyl)-γ-aminobutanoic acid;
 N-(O,O′-diethylphosphonomethyl)-β-aminoisobutanoic acid; N-(O,O′-diethylphosphonomethyl)-anserine; N-(O,O′-diethylphosphonomethyl)-aminolevulinic acid; N-(O,O′-diethylphosphonomethyl)-carnosine; N-(O,O′-diethylphosphonomethyl)-canaline; N-(O,O′-diethylphosphonomethyl)-canavanine; N-(O,O′-diethylphosphonomethyl)-citrulline; N-(O,O′-diethylphosphonomethyl)-creatine; N-(O,O′-diethylphosphonomethyl)-creatinine; N-(O,O′-diethylphosphonomethyl)-cysteine sulfinic acid; N-(O,O′-diethylphosphonomethyl)-cystine; N-(O,O′-diethylphosphonomethyl)-cycloserine; N-(O,O′-diethylphosphonomethyl)-dopa{N- (O,O′-diethylphosphonomethyl)-3,4-dihydroxyphenylalanine}; N-(O,O′-diethylphosphonomethyl)-dopamine; N-(O,O′-diethylphosphonomethyl)-ethionine; N-(O,O′-diethylphosphonomethyl)-glutathione; N-(O,O′-diethylphosphonomethyl)-guanidinoacetic acid; N-(O,O′-diethylphosphonomethyl)-3-guanidinopropanoic acid; N-(O,O′-diethylphosphonomethyl)-4-guanidinobutanoic acid; N-(O,O′-diethylphosphonomethyl)-homocarnosine; N-(O,O′-diethylphosphonomethyl)-homocysteine; N-(O,O′-diethylphosphonomethyl)-homoserine; N-(O,O′-diethylphosphonomethyl)-4-hydroxyphenylglycine; N-(O,O′-diethylphosphonomethyl)-hydroxyglutamic acid; N-(O,O′-diethylphosphonomethyl)-hydroxylysine; N-(O,O′-diethylphosphonomethyl)-hydroxyproline; N-(O,O′-diethylphosphonomethyl)-hypusine; N-(O,O′-diethylphosphonomethyl)-homoarginine; N-(O,O′-diethylphosphonomethyl)-homocitrulline; N-(O,O′-diethylphosphonomethyl)-homocystine; N-(O,O′-diethylphosphonomethyl)-homophenylalanine; N-(O,O′-diethylphosphonomethyl)-homotryptophan; N-(O,O′-diethylphosphonomethyl)-hydroxylysine; N-(O,O′-diethylphosphonomethyl)-hydroxyarginine; N-(O,O′-diethylphosphonomethyl)-hydroxyhomoarginine; N-(O,O′-diethylphosphonomethyl)-hydroxycitrulline; N-(O,O′-diethylphosphonomethyl)-hydroxyornithine; N-(O,O′-diethylphosphonomethyl)-hydroxyvaline; N-(O,O′-diethylphosphonomethyl)-indospicine; N-(O,O′-diethylphosphonomethyl)-methoxinine; N-(O,O′-diethylphosphonomethyl)-methylarginine; N-(O,O′-diethylphosphonomethyl)-methylhistidine; N-(O,O′-diethylphosphonomethyl)-methyllysine; N-(O,O′-diethylphosphonomethyl)-methylornithine; N-(O,O′-diethylphosphonomethyl)-methylserine; N-(O,O′-diethylphosphonomethyl)-norvaline; N-(O,O′-diethylphosphonomethyl)-ornithine; N-(O,O′-diethylphosphonomethyl)-oxalysine; N-(O,O′-diethylphosphonomethyl)-penicillamine; N-(O,O′-diethylphosphonomethyl)-phenylglycine; N-(O,O′-diethylphosphonomethyl)-3-phenylserine; N-(O,O′-diethylphosphonomethyl)-sarcosine (N-O,O′-diethylphosphonomethyl-N-methyl-glycine); N-(O,O′-diethylphosphonomethyl)-serotonin; N-(O,O′-diethylphosphonomethyl)-taurine; N-(O,O′-diethylphosphonomethyl)-tryptamine and N-(O,O′-diethylphosphonomethyl)-tyramine.   
   
   
       19 . The composition of  claim 1 , wherein the compound in ester form is an N-(O,O′-dialkylphosphonomethyl)-amino acid ester. 
   
   
       20 . The composition of  claim 19 , wherein the N-(O,O′-dialkylphosphonomethyl)-amino acid ester is N-(O,O′-diethylphosphonomethyl)-amino acid ester. 
   
   
       21 . The composition of  claim 20 , wherein the N-(O,O′-diethylphosphonomethyl)-amino acid ester in a form as a salt or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-alanine ester; N-(O,O′-diethylphosphonomethyl)-arginine ester; N-(O,O′-diethylphosphonomethyl)-asparagine ester; N-(O,O′-diethylphosphonomethyl)-aspartic acid ester; N-(O,O′-diethylphosphonomethyl)-cysteine ester; N-(O,O′-diethylphosphonomethyl)-glutamic ester; N-(O,O′-diethylphosphonomethyl)-glutamine ester; N-(O,O′-diethylphosphonomethyl)-glycine ester; N-(O,O′-diethylphosphonomethyl)-histidine ester; N-(O,O′-diethylphosphonomethyl)-isoleucine ester; N-(O,O′-diethylphosphonomethyl)-leucine ester; N-(O,O′-diethylphosphonomethyl)-lysine ester; N-(O,O′-diethylphosphonomethyl)-methionine ester; N- (O,O′-diethylphosphonomethyl)-phenylalanine ester; N-(O,O′-diethylphosphonomethyl)-proline ester; N-(O,O′-diethylphosphonomethyl)-serine ester; N-(O,O′-diethylphosphonomethyl)-threonine ester; N-(O,O′-diethylphosphonomethyl)-tryptophan ester; N-(O,O′-diethylphosphonomethyl)-tyrosine ester and N-(O,O′-diethylphosphonomethyl)-valine ester. 
   
   
       22 . The composition of  claim 20 , wherein the N-(O,O′-diethylphosphonomethyl)-amino acid, related compound or compound derived thereof in a form as a salt or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-β-alanine ester; N-(O,O′-diethylphosphonomethyl)-γ-aminobutanoic acid ester; N-(O,O′-diethylphosphonomethyl)-β-aminoisobutanoic acid ester; N-(O,O′-diethylphosphonomethyl)-anserine ester; N-(O,O′-diethylphosphonomethyl)-aminolevulinic acid ester; N-(O,O′-diethylphosphonomethyl)-carnosine ester; N-(O,O′-diethylphosphonomethyl)-canaline ester; N-(O,O′-diethylphosphonomethyl)-canavanine ester; N-(O,O′-diethylphosphonomethyl)-citrulline ester; N-(O,O′-diethylphosphonomethyl)-creatine ester; N-(O,O′-diethylphosphonomethyl)-creatinine ester; N-(O,O′-diethylphosphonomethyl)-cysteine sulfinic acid ester; N-(O,O′-diethylphosphonomethyl)-cystine ester; N-(O,O′-diethylphosphonomethyl)-dopa ester; N-(O,O′-diethylphosphonomethyl)-3,4-dihydroxyphenylalanine ester; N-(O,O′-diethylphosphonomethyl)-ethionine ester; N-(O,O′-diethylphosphonomethyl)-glutathione ester; N-(O,O′-diethylphosphonomethyl)-guanidinoacetic acid ester; N-(O,O′-diethylphosphonomethyl)-3-guanidinopropanoic acid ester; N-(O,O′-diethylphosphonomethyl)-4-guanidinobutanoic acid ester; N-(O,O′-diethylphosphonomethyl)-homocarnosine ester; N-(O,O′-diethylphosphonomethyl)-homocysteine ester; N-(O,O′-diethylphosphonomethyl)-homoserine ester; N-(O,O′-diethylphosphonomethyl)-4-hydroxyphenylglycine ester; N-(O,O′-diethylphosphonomethyl)-hydroxyglutamic acid ester; N-(O,O′-diethylphosphonomethyl)-hydroxylysine ester; N-(O,O′-diethylphosphonomethyl)-hydroxyproline ester; N-(O,O′-diethylphosphonomethyl)-hypusine ester; N-(O,O′-diethylphosphonomethyl)-homoarginine ester; N-(O,O′-diethylphosphonomethyl)-homocitrulline ester; N-(O,O′-diethylphosphonomethyl)-homocystine ester; N-(O,O′-diethylphosphonomethyl)-homophenylalanine ester; N-(O,O′-diethylphosphonomethyl)-homotryptophan ester; N-(O,O′-diethylphosphonomethyl)-hydroxylysine ester; N-(O,O′-diethylphosphonomethyl)-hydroxyarginine ester; N-(O,O′-diethylphosphonomethyl)-hydroxyhomoarginine ester; N-(O,O′-diethylphosphonomethyl)-hydroxycitrulline ester; N-(O,O′-diethylphosphonomethyl)-hydroxyornithine ester; N-(O,O′-diethylphosphonomethyl)-hydroxyvaline ester; N-(O,O′-diethylphosphonomethyl)-indospicine ester; N-(O,O′-diethylphosphonomethyl)-methoxinine ester; N-(O,O′-diethylphosphonomethyl)-methylarginine ester; N-(O,O′-diethylphosphonomethyl)-methylhistidine ester; N-(O,O′-diethylphosphonomethyl)-methyllysine ester; N-(O,O′-diethylphosphonomethyl)-methylornithine ester; N-(O,O′-diethylphosphonomethyl)-methylserine ester; N-(O,O′-diethylphosphonomethyl)-norvaline ester; N-(O,O′-diethylphosphonomethyl)-ornithine ester; N-(O,O′-diethylphosphonomethyl)-oxalysine ester; N-(O,O′-diethylphosphonomethyl)-penicillamine ester; N-(O,O′-diethylphosphonomethyl)-phenylglycine ester; N-(O,O′-diethylphosphonomethyl)-3-phenylserine ester; N-(O,O′-diethylphosphonomethyl)-sarcosine ester and N-(O,O′-diethylphosphonomethyl)-taurine ester. 
   
   
       23 . The composition of  claim 1 , wherein the compound in both ester and amide form is an N-(O,O′-dialkylphosphonomethyl)-aminoamide. 
   
   
       24 . The composition of  claim 23 , wherein the N-(O,O′-dialkylphosphonomethyl)-aminoamide is N-(O,O′-diethylphosphonomethyl)-aminoamide. 
   
   
       25 . The composition of  claim 24 , wherein the N-(O,O′-diethylphosphonomethyl)-aminoamide in a form as a salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-alanine amide; N-(O,O′-diethylphosphonomethyl)-arginine amide; N-(O,O′-diethylphosphonomethyl)-asparagine amide; N-(O,O′-diethylphosphonomethyl)-aspartic amide; N-(O,O′-diethylphosphonomethyl)-cysteine amide; N-(O,O′-diethylphosphonomethyl)-glutamic amide; N-(O,O′-diethylphosphonomethyl)-glutamine amide; N-(O,O′-diethylphosphonomethyl)-glycine amide; N-(O,O′-diethylphosphonomethyl)-histidine amide; N-(O,O′-diethylphosphonomethyl)-isoleucine amide; N-(O,O′-diethylphosphonomethyl)-leucine amide; N-(O,O′-diethylphosphonomethyl)-lysine amide; N-(O,O′-diethylphosphonomethyl)-methionine amide; N-(O,O′-diethylphosphonomethyl)-phenylalanine amide; N-(O,O′-diethylphosphonomethyl)-proline amide; N-(O,O′-diethylphosphonomethyl)-serine amide; N-(O,O′-diethylphosphonomethyl)-threonine amide; N-(O,O′-diethylphosphonomethyl)-tryptophan amide; N-(O,O′-diethylphosphonomethyl)-tyrosine amide and N-(O,O′-diethylphosphonomethyl)-valine amide. 
   
   
       26 . The composition of  claim 24 , wherein the N-(O,O′-diethylphosphonomethyl)-aminoamide, related compound or compound derived thereof in a form as a salt, amide or ester, or in stereoisomeric or non-stereoisomeric form, is selected from the group consisting of N-(O,O′-diethylphosphonomethyl)-β-alanine amide; N-(O,O′-diethylphosphonomethyl)-γ-aminobutanoic amide; N-(O,O′-diethylphosphonomethyl)-β-aminoisobutanoic amide; N-(O,O′-diethylphosphonomethyl)-anserine amide; N-(O,O′-diethylphosphonomethyl)-aminolevulinic amide; N-(O,O′-diethylphosphonomethyl)-carnosine amide; N-(O,O′-diethylphosphonomethyl)-canaline amide; N-(O,O′-diethylphosphonomethyl)-canavanine amide; N-(O,O′-diethylphosphonomethyl)-citrulline amide; N-(O,O′-diethylphosphonomethyl)-creatine amide; N-(O,O′-diethylphosphonomethyl)-creatinine amide; N-(O,O′-diethylphosphonomethyl)-cysteine sulfinic amide; N-(O,O′-diethylphosphonomethyl)-cystine amide; N-(O,O′-diethylphosphonomethyl)-dopa amide{N-(O,O′-diethylphosphonomethyl)-3,4-dihydroxyphenylalanine amide}; N-(O,O′-diethylphosphonomethyl)-ethionine amide; N-(O,O′-diethylphosphonomethyl)-glutathione amide; N-(O,O′-diethylphosphonomethyl)-guanidinoacetic amide; N-(O,O′-diethylphosphonomethyl)-3-guanidinopropanoic amide; N-(O,O′-diethylphosphonomethyl)-4-guanidinobutanoic amide; N-(O,O′-diethylphosphonomethyl)-homocarnosine amide; N-(O,O′-diethylphosphonomethyl)-homocysteine amide; N-(O,O′-diethylphosphonomethyl)-homoserine amide; N-(O,O′-diethylphosphonomethyl)-4-hydroxyphenylglycine amide; N-(O,O′-diethylphosphonomethyl)-hydroxyglutamic amide; N-(O,O′-diethylphosphonomethyl)-hydroxylysine amide; N-(O,O′-diethylphosphonomethyl)-hydroxyproline amide; N-(O,O′-diethylphosphonomethyl)-hypusine amide; N-(O,O′-diethylphosphonomethyl)-homoarginine amide; N-(O,O′-diethylphosphonomethyl)-homocitrulline amide; N-(O,O′-diethylphosphonomethyl)-homocystine amide; N-(O,O′-diethylphosphonomethyl)-homophenylalanine amide; N-(O,O′-diethylphosphonomethyl)-homotryptophan amide; N-(O,O′-diethylphosphonomethyl)-hydroxylysine amide; N-(O,O′-diethylphosphonomethyl)-hydroxyarginine amide; N-(O,O′-diethylphosphonomethyl)-hydroxyhomoarginine amide; N-(O,O′-diethylphosphonomethyl)-hydroxycitrulline amide; N-(O,O′-diethylphosphonomethyl)-hydroxyornithine amide; N-(O,O′-diethylphosphonomethyl)-hydroxyvaline amide; N-(O,O′-diethylphosphonomethyl)-indospicine amide; N-(O,O′-diethylphosphonomethyl)-methoxinine amide; N-(O,O′-diethylphosphonomethyl)-methylarginine amide; N-(O,O′-diethylphosphonomethyl)-methylhistidine amide; N-(O,O′-diethylphosphonomethyl)-methyllysine amide; N-(O,O′-diethylphosphonomethyl)-methylornithine amide; N-(O,O′-diethylphosphonomethyl)-methylserine amide; N-(O,O′-diethylphosphonomethyl)-norvaline amide; N-(O,O′-diethylphosphonomethyl)-ornithine amide; N-(O,O′-diethylphosphonomethyl)-oxalysine amide; N-(O,O′-diethylphosphonomethyl)-penicillamine amide; N-(O,O′-diethylphosphonomethyl)-phenylglycine amide; N-(O,O′-diethylphosphonomethyl)-3-phenylserine amide; N-(O,O′-diethylphosphonomethyl)-sarcosine amide and N-(O,O′-diethylphosphonomethyl)-taurine amide. 
   
   
       27 . The composition of  claim 1 , wherein the composition further comprises a cosmetic or pharmaceutical agent. 
   
   
       28 . The composition of  claim 27 , wherein the cosmetic or pharmaceutical agent is selected from the group consisting of hydroxyacids, ketoacids and related compounds; phenyl alpha acyloxyalkanoic acids and derivatives; N-acyl-aldosamines, N-acylamino acids and related N-acyl compounds; local analgesics and anesthetics; anti-acne agents; anti-bacterial agents; anti-yeast agents; anti-fungal agents; anti-viral agents; anti-infective agents; anti-dandruff agents; anti-dermatitis agents; anti-eczema agents; anti-histamine agents; anti-pruritic agents; anti-emetics; anti-motion sickness agents; anti-inflammatory agents; anti-hyperkeratotic agents; antiperspirants; anti-psoriatic agents; anti-rosacea agents; anti-seborrheic agents; hair conditioners and hair treatment agents; anti-aging and anti-wrinkle agents; anti-anxiety agents; anti-convulsant agents; anti-depressant agents; sunblock and sunscreen agents; skin lightening agents; depigmenting agents; astringents; cleansing agents; corn, callus or wart removing agents; skin plumping agents; skin volumizing agents; skin firming agents; matrix metalloproteinase (MMP) inhibitors; topical cardiovascular agents; wound-healing agents; gum disease or oral care agents; amino acids; peptides; dipeptides; tripeptides; glutathione and its derivatives; oligopeptides; polypeptides; carbohydrates; aminocarbohydrates; vitamins; corticosteroids; tanning agents; hormones and retinoids. 
   
   
       29 . The composition of  claim 28 , wherein the cosmetic or pharmaceutical agent as stated or as free base, free acid, ester, amide, lactone or salt form is selected from the group consisting of: abacavir, abciximab, acamprosate, acarbose, acebutolol, acetaminophen, acetaminosalol, acetazolamide, acetic acid, acetohydroxamic acid, N-acetylcysteine and its esters, N-acetylglutathione and its esters, acitretin, aclometasone dipropionate, acrivastine, acthrel, actidose, actigall, acyclovir, adalimumab, adapalene, adefovir dipivoxil, adenosine, agalsidase, albendazole, albumin, albuterol, aldesleukin, alefacept, alemtuzumab, alendronate, alfuzosin, alitretinoin, allantoin, allium, allopurinol, alloxanthine, almotriptan, alosetron, alpha tocopheral, alpha 1 -proteinase, alprazolam, alprenolol, alprostadil, alteplase, altretamine, aluminum acetate, aluminum chloride, aluminum chlorohydroxide, aluminum hydroxide, amantadine, amifostine, amiloride, aminacrine, amino acid, aminobenzoate, p-aminobenzoic acid, aminocaproic acid, aminohippurate, aminolevulinic acid, aminosalicylic acid, amiodarone, amitriptyline, amlodipine, amocarzine, amodiaquin, amorolfine, amoxapine, amoxicillin, amphetamine, amphotericin, ampicillin, amprenavir, anagrelide, anakinra, anastrozole, anisindione, anthralin, antihemophilic, antithrombin, anti-thymocyte, antivenin, apomorphine, aprepitant, aprotinin, arbutin, argatroban, aripiprazole, arnica, ascorbic acid and its esters, ascorbyl palmitate, aspirin, atazanavir, atenolol, atomoxetine, atorvastatin, atovaquone, atropine, azathioprine, azelaic acid, azelastine, azithromycin, baclofen, bacitracin, balsalazide, balsam, basiliximab, beclomethasone dipropionate, bemegride, benazepril, bendroflumethiazide, benzocaine, benzonatate, benzophenone, benzoyl peroxide, benztropine, bepridil, beta carotene, betamethasone dipropionate, betamethasone valerate, betaxolol, bethanechol, bevacizumab, bexarotene, bicalutamide, bimatoprost, bioflavonoids, biotin, biperiden, bisacodyl, bisoprolol, bivalirudin, bortezomib, bosentan, botulinum, brimonidine, brinzolamide, bromocriptine, brompheniramine, budesonide, bumetanide, bupivacaine, buprenorphine, bupropion, burimamide, buspirone, busulfan, butabarbital, butalbital, butenafine, butoconazole, butorphanol, butyl aminobenzoate, cabergoline, caffeic acid, caffeine, calcipotriene, calcitonin-salmon, calcitriol, calfactant, camellia sinensis, camphor, candesartan cilexetil, capecitabine, capreomycin, capsaicin, captopril, carbamazepine, carbamide peroxide, carbidopa, carbinoxamine, cefditoren pivoxil, cefepime, cefpodoxime proxetil, celecoxib, cetirizine, cevimeline, chitosan, chlordiazepoxide, chlorhexidine, chloroquine, chlorothiazide, chloroxylenol, chlorpheniramine, chlorpromazine, chlorpropamide, ciclopirox, cilostazol, cimetidine, cinacalcet, ciprofloxacin, citalopram, citric acid, cladribine, clarithromycin, clemastine, clindamycin, clioquinol, clobetasol propionate, clocortolone pivalate, clomiphene, clonidine, clopidogrel, clotrimazole, clozapine, coal tar, coal tar extracts (LCD), codeine, cromolyn, crotamiton, cyclizine, cyclobenzaprine, cycloserine, cytarabine, dacarbazine, dalfopristin, dapsone, daptomycin, daunorubicin, deferoxamine, dehydroepiandrosterone, delavirdine, desipramine, desloratadine, desmopres sin, desoximetasone, dexamethasone, dexmedetomidine, dexmethylphenidate, dexrazoxane, dextroamphetamine, diazepam, diclofenac, dicyclomine, didanosine, dihydrocodeine, dihydromorphine, diltiazem, 6,8-dimercaptooctanoic acid (dihydrolipoic acid), diphenhydramine, diphenoxylate, dipyridamole, disopyramide, dobutamine, dofetilide, dolasetron, donepezil, dopa esters, dopamide, dopamine, dorzolamide, doxepin, doxorubicin, doxycycline, doxylamine, doxepin, duloxetine, dyclonine, econazole, efalizumab, eflornithine, eletriptan, emtricitabine, enalapril, ephedrine, epinephrine, epinine, epirubicin, eptifibatide, ergotamine, erythromycin, escitalopram, esmolol, esomeprazole, estazolam, estradiol, etanercept, ethacrynic acid, ethinyl estradiol, etidocaine, etomidate, famciclovir, famotidine, felodipine, fentanyl, ferulic acid, fexofenadine, flecainide, fluconazole, flucytosine, fluocinolone acetonide, fluocinonide, 5-fluorouracil, fluoxetine, fluphenazine, flurazepam, fluticasone propionate, fluvoxamine, formoterol, furosemide, galactarolactone, galactonic acid, galactonolactone, galantamine, gatifloxacin, gefitinib, gemcitabine, gemifloxacin, glucarolactone, gluconic acid, gluconolactone, glucuronic acid, glucuronolactone, glycolic acid, griseofulvin, guaifenesin, guanethidine, N-guanylhistamine, haloperidol, haloprogin, hexylresorcinol, homatropine, homosalate, hydralazine, hydrochlorothiazide, hydrocortisone, hydrocortisone 21-acetate, hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrogen peroxide, hydromorphone, hydroquinone, hydroquinone monoether, hydroxyzine, hyoscyamine, hypoxanthine, ibuprofen, ichthammol, idarubicin, imatinib, imipramine, imiquimod, indinavir, indomethacin, infliximab, irbesartan, irinotecan, isoetharine, isoproterenol, itraconazole, kanamycin, ketamine, ketanserin, ketoconazole, ketoprofen, ketotifen, kojic acid, labetalol, lactic acid, lactobionic acid, lamivudine, lamotrigine, lansoprazole, letrozole, leuprolide, levalbuterol, levofloxacin, lidocaine, linezolid, lobeline, loratadine, loperamide, losartan, loxapine, lysergic diethylamide, mafenide, malic acid, maltobionic acid, mandelic acid, maprotiline, mebendazole, mecamylamine, meclizine, meclocycline, memantine, menthol, meperidine, mepivacaine, mequinol, mercaptopurine, mescaline, metanephrine, metaproterenol, metaraminol, metformin, methadone, methamphetamine, methotrexate, methoxamine, methyldopa esters, methyldopamide, 3,4-methylenedioxymethamphetamine, methyllactic acid, methyl nicotinate, methylphenidate, methyl salicylate, metiamide, metolazone, metoprolol, metronidazole, mexiletine, miconazole, midazolam, midodrine, miglustat, minocycline, minoxidil, mirtazapine, mitoxantrone, moexiprilat, molindone, monobenzone, morphine, moxifloxacin, moxonidine, mupirocin, nadolol, naftifine, nalbuphine, nalmefene, naloxone, naproxen, nefazodone, nelfinavir, neomycin, nevirapine, nicardipine, nicotine, nifedipine, nimodipine, nisoldipine, nitrofurantoin, nizatidine, norepinephrine, nystatin, octopamine, octreotide, octyl methoxycinnamate, octyl salicylate, ofloxacin, olanzapine, olmesartan medoxomil, olopatadine, omeprazole, ondansetron, oxiconazole, oxotremorine, oxybenzone, oxybutynin, oxycodone, oxymetazoline, padimate O, palonosetron, pantothenic acid, pantoyl lactone, paroxetine, pemoline, penciclovir, penicillamine, penicillins, pentazocine, pentobarbital, pentostatin, pentoxifylline, pergolide, perindopril, permethrin, phencyclidine, phenelzine, pheniramine, phenmetrazine, phenobarbital, phenol, phenoxybenzamine, phentolamine, phenylephrine, phenylpropanolamine, phenytoin, physostigmine, pilocarpine, pimecrolimus, pimozide, pindolol, pioglitazone, pipamazine, piperonyl butoxide, pirenzepine, podofilox, povidone iodine, pramipexole, pramoxine, prazosin, prednisone, prenalterol, prilocaine, procainamide, procaine, procarbazine, promazine, promethazine, promethazine propionate, propafenone, propoxyphene, propranolol, propylthiouracil, protriptyline, pseudoephedrine, pyrethrin, pyrilamine, pyrimethamine, quetiapine, quinapril, quinethazone, quinidine, quinupristin, rabeprazole, reserpine, resorcinol, retinal, 13-cis retinoic acid, retinoic acid, retinol, retinyl acetate, retinyl palmitate, ribavirin, ribonic acid, ribonolactone, rifampin, rifapentine, rifaximin, riluzole, rimantadine, risedronic acid, risperidone, ritodrine, rivastigmine, rizatriptan, ropinirole, ropivacaine, salicylamide, salicylic acid, salmeterol, scopolamine, selegiline, selenium sulfide, serotonin, sertaconazole, sertindole, sertraline, shale tar, sibutramine, sildenafil, sotalol, streptomycin, strychnine, sulconazole, sulfacetamide, sulfabenz, sulfabenzamide, sulfabromomethazine, sulfacetamide (sodium sulfacetamide), sulfachlorpyridazine, sulfacytine, sulfadiazine, sulfadimethoxine, sulfadoxine, sulfaguanole, sulfalene, sulfamethizole, sulfamethoxazole, sulfanilamide, sulfapyrazine, sulfapyridine, sulfasalazine, sulfasomizole, sulfathiazole, sulfisoxazole, sulfur, tacrolimus, tadalafil, tamsulosin, tartaric acid, tazarotene, tegaserod, telithromycin, telmisartan, temozolomide, tenofovir disoproxil, terazosin, terbinafine, terbutaline, terconazole, terfenadine, tetracaine, tetracycline, tetrahydrozoline, thalidomide, theobromine, theophylline, thiabendazole, thioctic acid (lipoic acid), thioridazine, thiothixene, thymol, tiagabine, timolol, tinidazole, tioconazole, tirofiban, tizanidine, tobramycin, tocainide, tolazoline, tolbutamide, tolnaftate, tolterodine, tramadol, tranylcypromine, trazodone, triamcinolone acetonide, triamcinolone diacetate, triamcinolone hexacetonide, triamterene, triazolam, triclosan, triflupromazine, trimethoprim, trimipramine, tripelennamine, triprolidine, tromethamine, tropic acid, tyramine, undecylenic acid, urea, urocanic acid, ursodiol, valacyclovir, vardenafil, venlafaxine, verapamil, vitamin E acetate, voriconazole, warfarin, wood tar, xanthine, zafirlukast, zaleplon, zinc pyrithione, ziprasidone, zolmitriptan and zolpidem. 
   
   
       30 . The composition of  claim 1 , wherein the cosmetic conditions or dermatological disorders are selected from the group consisting of disturbed keratinization; changes associated with intrinsic and extrinsic aging; and others; including acne; rosacea; age spots; blemished skin; blotches; cellulite; dermatoses; dermatitis; skin, nail and hair infections; dandruff; dryness or looseness of skin, nail and hair; xerosis; eczema; elastosis; herpes; hyperkeratosis; hyperpigmented skin; ichthyosis; keratoses; lentigines; melasmas; mottled skin; pseudofolliculitis barbae; photoaging and photodamage; pruritus; psoriasis; skin lines; stretch marks; thinning of skin, nail plate and hair; warts; wrinkles; breakdown, defective synthesis or repair of dermal components; abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans and elastin, as well as diminished levels of such components in the dermis; uneven skin tone; uneven and rough surface of skin, nail and hair; loss or reduction of skin, nail and hair resiliency, elasticity and recoilability; laxity; lack of skin, nail and hair lubricants and luster; fragility and splitting of nail and hair; yellowing skin; reactive, irritating or telangiectatic skin; dull and older-looking skin, nail and hair; for general care of skin, nail and hair; to improve skin texture and pores, flakiness and redness; to make skin soft, smooth, fresh, balanced, visibly clear, even-toned and brighter; to increase skin fullness and plumpness; and for skin bleach and lightening and wound healing. 
   
   
       31 . The composition of  claim 1 , wherein N-(phosphonoalkyl)-amino acid is selected from the group consisting of N-(phosphonomethyl)-glycine, N-(phosphonomethyl)-glycine amide, N-(phosphonomethyl)-glycine ester, N-(O,O′-diethylphosphonomethyl)-glycine, N-(O,O′-diethylphosphonomethyl)-glycine amide and N-(O,O′-diethylphosphonomethyl)-glycine ester, and the composition is used for topical or systemic administration to a mammalian subject for treatment of cosmetic conditions or dermatological disorders. 
   
   
       32 . The composition of  claim 31 , wherein cosmetic conditions or dermatological disorders are selected from the group consisting of disturbed keratinization; acne; hyperkeratosis and ichthyosis.