HIV Protease Inhibiting Compounds

Abstract

A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

1 . A compound of formula (I), 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug, or stereoisomer thereof, wherein: 
       A is 
     
     
       
         
         
             
             
         
       
       X is O, S or NH; 
       Y is O, S or NH; 
       B is H or —CH 2 R 9 ; 
       L is —C(═O), —C(═S), —C(═NH) or —S(O) 2 ; 
       R A  is —N(H)C(O)R 8 , —O(R a ), —OC(O)OR a , —NR a R b , —N(R b )S(O) 2 R a , —N(R b )alkylN(R b )S(O) 2 R a , —N(R b )alkylN(R b )C(O)OR a , —N(R b )alkylN(R b )C(O)NR a R b , -alkylSR a , -alkylS(O)R a  or -alkylS(O) 2 R a ; 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —S 0 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 8  is —OR a , —NR a R b , —N(R b )C(O)OR a , -alkylOR a , -alkylOC(O)R a , or —O-alkylC(O)R a ; 
       R 9  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 9  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 9a ; 
       R 9a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 9a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 10  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 10  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 10a ; 
       R 10a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 10a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 11  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 11  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 11a ; 
       R 11a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 11a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 12  is alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl or cycloalkenylalkyl; wherein each R 12  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy and halo; 
       R 13  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 13  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkyl-C(O)NR a R b  and R 13a ; 
       R 13a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 13a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 14  is —OR a , -alkylOR a , aryl, heteroaryl or heterocycle; wherein the aryl, heteroaryl and heterocycle are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —S 0 2 (alkyl), —S(O) 2 NR a R b , —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4—CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, 5(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is 0 or 1; 
       m is 0 or 1; 
       m′ is 0 or 1; 
       m″ is 0 or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is 0 or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; and 
       n is 1 or 2. 
     
   
   
       2 . The compound of  claim 1  wherein R 4  is H and R 5  is OR 16 . 
   
   
       3 . The compound of  claim 1  wherein R 4  is OR 16  and R 5  is H. 
   
   
       4 . The compound of  claim 1 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, selected from the group consisting of:
 methyl 7-benzyl-1,10-ditert-butyl-6-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-{[(1-benzyl-3-hydroxy-4-{[3-methyl-2-(2-oxo-3-{[2-(2-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)pentanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl 1-({[1-benzyl-3-hydroxy-4-({3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl 1-({[1-benzyl-3-hydroxy-4-({3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2-methylbutylcarbamate;   methyl 1-{[(1-benzyl-3-hydroxy-4-{[2-(3-{[2-(methoxymethyl)-1,3-thiazol-4-yl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-3-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-2-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-2-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2-methylbutylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-2-hydroxy-4-[(3-methyl-2-{3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-{[(1-benzyl-2-hydroxy-4-{[3-methyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)pentanoyl]amino }-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-2-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-2-hydroxy-4-[(3-methyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-{[(1-benzyl-2-hydroxy-4-{[2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-{[(1-benzyl-4-{[3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl 1-({[1-benzyl-4-({3,3-dimethyl-2-[2-oxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-2-hydroxy-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(3-methyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-3-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-3-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-2-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-2-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   methyl 1-[({2-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-(methylsulfanyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-(methylsulfonyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 4-benzyl-10-tert-butyl-6-hydroxy-1-[1-methyl-1-(methylsulfanyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 4-benzyl-10-tert-butyl-6-hydroxy-1-[1-methyl-1-(methylsulfonyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-{[(2S)-3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino }-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({2-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-({(2S)-2-[3-(imidazo [1,5-a]pyridin-3-ylmethyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({2-hydroxy-4-({2-[3-(imidazo[1,5-a]pyridin-3-ylmethyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({2-hydroxy-4-{[2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino }-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-{[2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino }-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-2-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl 1-benzyl-2-hydroxy-4-({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   methyl 1-[({4-{[3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino }-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-{[2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino }-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[(phenoxyacetyl)amino]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-6-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-14-oxa-3,8,11-triazapentadec-1-ylcarbamate;   methyl 1-[({3-hydroxy-4-[(2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2,4-dioxo-1-imidazolidinyl}-3-methylpentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[2-(2,4-dioxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)-3-methylpentanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[3,3-dimethyl-2-({[(6-methyl-3-pyridinyl)oxy]acetyl}amino)butanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   3-pyridinylmethyl 4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   benzyl 4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-6-hydroxy-13-methyl-2,9,12-trioxo-14-phenyl-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-6-hydroxy-13-methyl-2,9,12-trioxo-14-phenyl-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[3-(2-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[3-(3-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-({2-[3-(3-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(4-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-({2-[3-(2-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[3-(2-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[3-(3-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-({2-[3-(2-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-({2-[3-(3-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(4-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[2-oxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[2-oxo-3-(4-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({3,3-dimethyl-2-[2-oxo-3-(2-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-(6-methyl-3-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methyl-3-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-[5-methyl-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2-methylbutylcarbamate;   methyl 4-benzyl-1,10-ditert-butyl-5-hydroxy-7-[4-(5-methyl-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-((R)-methylsulfinyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({2-hydroxy-4-[(3-methyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({2-hydroxy-4-[(2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3-methylpentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({2-hydroxy-4-[(2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(3-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(4-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-10-sec-butyl-1-tert-butyl-6-hydroxy-13-methyl-14-(2-methyl-1,3-thiazol-4-yl)-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl 7-benzyl-10-sec-butyl-1-tert-butyl-5-hydroxy-13-methyl-14-(2-methyl-1,3-thiazol-4-yl)-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   1,2,5,6-tetradeoxy-2,5-bis({2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-1,6-bis[4-(2-pyridinyl)phenyl]-D-iditol;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(2-{3-[(6-tert-butyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4,7-bis[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({3-hydroxy-4-[(2-{3-[(6-isopropyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(2-{3-[(6-tert-butyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({-4-{[2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-(6-methoxy-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 4-benzyl-1,10-ditert-butyl-5-hydroxy-7-[4-(6-methoxy-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({2-[3-(2-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({2-[3-(4-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-({2-[3-(3-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({3-hydroxy-4-[(2-{3-[(6-isopropyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 1-[({1-benzyl-4-[(3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl 4-benzyl-1,10-disec-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 1-({[1-benzyl-2-hydroxy-4-({3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(3-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[2-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[4-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[3-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(2-amino-3-methylbenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-[(3R)-tetrahydrofuran-3-yl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(3-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(4-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(2-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(1,3-thiazol-2-yl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(1S)-1-methylpropyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-3-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{R2S)-2-methyl-3-(methylsulfonyl)propanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-4-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(2S)-2-hydroxy-3,3-dimethylbutanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-12,12-dioxido-2,9-dioxo-4-(4-pyridin-2-ylbenzyl)-12-thia-3,8,11-triazatridec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(methylthio)methyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(methylsulfonyl)methyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R)-1-{[((1S,2S,4S)-4-{[4-(aminosulfonyl)benzoyl]amino}-1-benzyl-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(2R)-2-hydroxy-3-methyl-3-(methylsulfonyl)butanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-[(4-chloro-2-methylbenzoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-[(4-methoxy-2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-[(2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-3,3-dimethyl-2-(2-oxoimidazolidin-1-yl)butanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-{[(2S,3S)-3-methyl-2-(2-oxoimidazolidin-1-yl)pentanoyl]amino }-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-4-{[3-(aminosulfonyl)benzoyl]amino}-1-benzyl-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[(3-chloro-2-methylbenzoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-[(3-hydroxy-2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(3-methylisoxazol-4-yl)carbonyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(3,5-dimethylisoxazol-4-yl)carbonyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-isobutyl-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-1-(2-amino-2-oxoethyl)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 2-{[(1S,2S,4S)-1-benzyl-2-hydroxy-4-{[N-(methoxycarbonyl)-3-methyl-L-valyl]amino}-5-(4-pyridin-2-ylphenyl)pentyl]amino}-1-[(methoxycarbonyl)amino]-2-oxoethylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-2,9,12,14-tetraoxo-4-(4-pyridin-2-ylbenzyl)-15-oxa-3,8,11,13-tetraazahexadec-1-ylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-14,14-dimethyl-2,9,12,15-tetraoxo-4-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazahexadec-1-ylcarbamate;   (4S,7S,8S,10S,13S)-7-benzyl-4,13-di-tert-butyl-8-hydroxy-2,5,12,15-tetraoxo-10-(4-pyridin-2-ylbenzyl)-16-oxa-3,6,11,14-tetraazaheptadec-1-yl acetate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(2S)-2-(glycoloylamino)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (3S,6S,7S,9S,12S)-6-benzyl-3-[(tert-butoxycarbonyl)amino]-12-tert-butyl-7-hydroxy-2,2-dimethyl-4,11,14-trioxo-9-(4-pyridin-2-ylbenzyl)-15-oxa-5,10,13-triazahexadec-1-yl acetate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-(2-hydroxy-1,1-dimethylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-1-{[(aminocarbonyl)amino]methyl}-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-(pyridin-2-ylmethyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-(1,3-thiazol-4-ylmethyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   (3S,6S,7S,9S,12S)-6-benzyl-12-tert-butyl-7-hydroxy-3-[(methoxycarbonyl)amino]-2,2-dimethyl-4,11,14-trioxo-9-(4-pyridin-2-ylbenzyl)-15-oxa-5,10,13-triazahexadec-1-yl acetate;   methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-15,15-dioxido-2,9-dioxo-4-(4-pyridin-2-ylbenzyl)-15-thia-3,8,11,14-tetraazahexadec-1-ylcarbamate;   methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-2,9,15-trioxo-4-(4-pyridin-2-ylbenzyl)-16-oxa-3,8,11,14-tetraazaheptadec-1-ylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-2-(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(5S,8S,10S,11S,14S)-11-benzyl-5-tert-butyl-10-hydroxy-14-[(methoxycarbonyl)amino]-15-methyl-3,6,13-trioxo-8-(4-pyridin-2-ylbenzyl)-2-oxa-4,7,12-triazahexadecan-16-oate;   methyl(5S,8S,10S,11S,14S)-11-benzyl-5-tert-butyl-10-hydroxy-14-[(methoxycarbonyl)amino]-15,15-dimethyl-3,6,13-trioxo-8-(4-pyridin-2-ylbenzyl)-2-oxa-4,7,12-triazahexadecan-16-oate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-5-phenyl-4-[(thien-2-ylcarbonyl)amino]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-5-phenyl-4-[(thien-3-ylcarbonyl)amino]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(3-methylthien-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(5-methylthien-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-4-{[(3,5-dimethylisoxazol-4-yl)carbonyl]amino}-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-5-phenyl-3-(phosphonooxy)-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]methyl}-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-5-phenyl-3-(phosphonooxy)-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl(2S)-2-aminopropanoate;   methyl(1S)-1-({[(1R,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-({6-[1-methyl-1-(phosphonooxy)ethyl]pyridin-2-yl}methyl)-2-oxoimidazolidin-1-yl]butanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (3S,5S,8S)-3-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-8-tert-butyl-7,10-dioxo-5-(4-pyridin-2-ylbenzyl)-2,11-dioxa-6,9-diazadodec-1-yl(dimethylamino)acetate;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl(phosphonooxy)methyl carbonate;   (5S,7S,10S)-5-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino }-2-phenylethyl)-10-tert-butyl-3,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-2,4,13-trioxa-8,11-diazatetradec-1-yl(dimethylamino)acetate;   (5S,8S,10S)-10-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino }-2-phenylethyl)-5-tert-butyl-3,6,12-trioxo-8-(4-pyridin-2-ylbenzyl)-2,11-dioxa-4,7-diazapentadecan-15-oic acid;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl{[ethoxy(hydroxy)phosphoryl]oxy}methyl carbonate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino -2-phenylethyl)-1-tert-butyl-10-hydroxy-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9,11-trioxa-3-aza-10-phosphatridec-1-ylcarbamate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino -2-phenylethyl)-1-tert-butyl-10,10-dihydroxy-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9-dioxa-3-aza-10-phosphadec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-(phosphonooxy)-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-4-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-1-tert-butyl-10,10-dihydroxy-8-methyl-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9-dioxa-3-aza-10-phosphadec-1-ylcarbamate;   methyl(1S,4S,5S)-4-benzyl-1-tert-butyl-5-{(2S)-2-[((2S)-3,3-dimethyl-2-{3-[(6-methylpyridin-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoyl)amino]-3-phenylpropyl}-9,9-dihydroxy-9-oxido-2-oxo-6,8-dioxa-3-aza-9-phosphanon-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[1-(phosphonooxy)ethoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate; and   methyl(1S)-3-amino-1-({[(1S,2S,4S)-1-benzyl-2-hydroxy-4-{[N-(methoxycarbonyl)-3-methyl-L-valyl]amino -5-(4-pyridin-2-ylphenyl)pentyl]amino}carbonyl)-2,2-dimethyl-3-oxopropylcarbamate.   
   
   
       5 . The compound of  claim 1  having formula (II) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug, or a stereoisomer thereof, wherein: 
       R A  is —N(H)C(O)R 8 , —O(R a ), —OC(O)OR a , —NR a R b , —N(R b )S(O) 2 R a , —N(R b )alkylN(R b )S(O) 2 R a , —N(R b )alkylN(R b )C(O)OR a , —N(R b )alkylN(R b )C(O)NR a R b , -alkylSR a , -alkylS(O)R a  or -alkylS(O) 2 R a ; 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —S 0 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —S 0 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 8  is —OR a , —NR a R b , —N(R b )C(O)OR a , -alkylOR a , -alkylOC(O)R a , or —O-alkylC(O)R a ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, 5(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is 0 or 1; 
       m is 0 or 1; 
       m′ is 0 or 1; 
       m″ is 0 or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is 0 or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; and 
       R, is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 . 
     
   
   
       6 . The compound of  claim 5  wherein R 4  is H and R 5  is OR 16 . 
   
   
       7 . The compound of  claim 5  wherein R 4  is OR 16  and R 5  is H. 
   
   
       8 . The compound of  claim 5  wherein R 4  is H, R 5  is OR 16  and R 2  is alkyl. 
   
   
       9 . The compound of  claim 5  wherein R 4  is OR 16 , R 5  is H, and R 2  is alkyl. 
   
   
       10 . The compound of  claim 5  wherein R 4  is H, R 5  is OR 16 , R 2  is alkyl, R 3  is arylalkyl substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       11 . The compound of  claim 5  wherein R 4  is OR 16 , R 5  is H, R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       12 . The compound of  claim 5 , or a pharmaceutically acceptable salt form, prodrug, or a stereoisomer thereof, selected from the group consisting of:
 methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-ditert-butyl-6-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-(methylsulfanyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-(methylsulfonyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,6S,7S,10S)-4-benzyl-10-tert-butyl-6-hydroxy-1-[1-methyl-1-(methylsulfanyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,6S,7S,10S)-4-benzyl-10-tert-butyl-6-hydroxy-1-[1-methyl-1-(methylsulfonyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[(phenoxyacetyl)amino]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-ditert-butyl-6-hydroxy-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-14-oxa-3,8,11-triazapentadec-1-ylcarbamate;   methyl(1,S)-1-[({(1S,3S,4S)-4-{[(2S)-3,3-dimethyl-2-({[(6-methyl-3-pyridinyl)oxy]acetyl}amino)butanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   3-pyridinylmethyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   benzyl (1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-(6-methyl-3-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-(5-methyl-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-7-[4-(5-methyl-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-((R)-methylsulfinyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[1-methyl-1-((S)-methylsulfinyl)ethyl]-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(3-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4-[4-(4-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   1,2,5,6-tetradeoxy-2,5-bis({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-1,6-bis[4-(2-pyridinyl)phenyl]-D-iditol;   methyl(1S,4R,5R,7R,10S)-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-4,7-bis[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-ditert-butyl-5-hydroxy-4-[4-(6-methoxy-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-7-[4-(6-methoxy-2-pyridinyl)benzyl]-2,9,12-trioxo-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-disec-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-[(3R)-tetrahydro furan-3-yl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(1,3-thiazol-2-yl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(1S)-1-methylpropyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-3-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(2S)-2-methyl-3-(methylsulfonyl)propanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-4-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(2S)-2-hydroxy-3,3-dimethylbutanoyl]amino }-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-12,12-dioxido-2,9-dioxo-4-(4-pyridin-2-ylbenzyl)-12-thia-3,8,11-triazatridec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(methylthio)methyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1R,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-[(methylsulfonyl)methyl]-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(2R)-2-hydroxy-3-methyl-3-(methylsulfonyl)butanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-isobutyl-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-1-(2-amino-2-oxo ethyl)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl 2-{[(1S,2S,4S)-1-benzyl-2-hydroxy-4-{[N-(methoxycarbonyl)-3-methyl-L-valyl]amino}-5-(4-pyridin-2-ylphenyl)pentyl]amino }-1-[(methoxycarbonyl)amino]-2-oxoethylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-2,9,12,14-tetraoxo-4-(4-pyridin-2-ylbenzyl)-15-oxa-3,8,11,13-tetraazahexadec-1-ylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-14,14-dimethyl-2,9,12,15-tetraoxo-4-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazahexadec-1-ylcarbamate;   (4S,7S,8S,10S,13S)-7-benzyl-4,13-di-tert-butyl-8-hydroxy-2,5,12,15-tetraoxo-10-(4-pyridin-2-ylbenzyl)-16-oxa-3,6,11,14-tetraazaheptadec-1-yl acetate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(2S)-2-(glycoloylamino)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (3S,6S,7S,9S,12S)-6-benzyl-3-[(tert-butoxycarbonyl)amino]-12-tert-butyl-7-hydroxy-2,2-dimethyl-4,11,14-trioxo-9-(4-pyridin-2-ylbenzyl)-15-oxa-5,10,13-triazahexadec-1-yl acetate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-1-(2-hydroxy-1,1-dimethylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-1-{[(aminocarbonyl)amino]methyl}-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-(pyridin-2-ylmethyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-10-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-1-(1,3-thiazol-4-ylmethyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   (3S,6S,7S,9S,12S)-6-benzyl-12-tert-butyl-7-hydroxy-3-[(methoxycarbonyl)amino]-2,2-dimethyl-4,11,14-trioxo-9-(4-pyridin-2-ylbenzyl)-15-oxa-5,10,13-triazahexadec-1-ylacetate;   methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-15,15-dioxido-2,9-dioxo-4-(4-pyridin-2-ylbenzyl)-15-thia-3,8,11,14-tetraazahexadec-1-ylcarbamate;   methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-di-tert-butyl-6-hydroxy-2,9,15-trioxo-4-(4-pyridin-2-ylbenzyl)-16-oxa-3,8,11,14-tetraazaheptadec-1-ylcarbamate;   methyl(5S,8S,10S,11S,14S)-11-benzyl-5-tert-butyl-10-hydroxy-14-[(methoxycarbonyl)amino]-15-methyl-3,6,13-trioxo-8-(4-pyridin-2-ylbenzyl)-2-oxa-4,7,12-triazahexadecan-16-oate;   methyl(5S,8S,10S,11S,14S)-11-benzyl-5-tert-butyl-10-hydroxy-14-[(methoxycarbonyl)amino]-15,15-dimethyl-3,6,13-trioxo-8-(4-pyridin-2-ylbenzyl)-2-oxa-4,7,12-triazahexadecan-16-oate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-(phosphonooxy)-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-7-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-4-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[1-(phosphonooxy)ethoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate; and   methyl(1S)-3-amino-1-({[(1S,2S,4S)-1-benzyl-2-hydroxy-4-{[N-(methoxycarbonyl)-3-methyl-L-valyl]amino}-5-(4-pyridin-2-ylphenyl)pentyl]amino}carbonyl)-2,2-dimethyl-3-oxopropylcarbamate.   
   
   
       13 . The compound of  claim 1  having formula (III) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug or a stereoisomer thereof, wherein: 
       B is H or —CH 2 R 9 ; 
       L is —C(═O), —C(═S), —C(═NH) or —S(O) 2 ; 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 9  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 9  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 9a ; 
       R 9a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 9a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, S(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is O or 1; 
       m is O or 1; 
       m′ is O or 1; 
       m″ is O or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is O or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; and 
       n is 1 or 2. 
     
   
   
       14 . The compound of  claim 13  wherein R 4  is H and R 5  is OR 16 . 
   
   
       15 . The compound of  claim 13  wherein R 4  is OR 16  and R 5  is H. 
   
   
       16 . The compound of  claim 13  wherein R 4  is H, R 5  is OR 16 , L is —C(═O) or —C(═S) and R 2  is alkyl. 
   
   
       17 . The compound of  claim 13  wherein R 4  is OR 16 , R 5  is H, L is —C(═O) or —C(═S) and R 2  is alkyl. 
   
   
       18 . The compound of  claim 13  wherein R 4  is H, R 5  is OR 16 , L is —C(═O) or —C(═S), R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       19 . The compound of  claim 13  wherein R 4  is OR 16 , R 5  is H, L is —C(═O) or —C(═S), R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       20 . The compound of  claim 13  wherein R 4  is H, R 5  is OR 16 , L is —C(═O) or —C(═S), R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a  wherein R 3a  is aryl or heteroaryl and R 9  is aryl or heteroaryl. 
   
   
       21 . The compound of  claim 13  wherein R 4  is OR 16 , R 5  is H, L is —C(═O) or —C(═O), R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a  wherein R 3a  is aryl or heteroaryl and R 9  is aryl or heteroaryl. 
   
   
       22 . The compound of  claim 13 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, selected from the group consisting of:
 methyl(1S)-1-{[((1S,3S,4S)-1-benzyl-3-hydroxy-4-{[(2S)-3-methyl-2-(2-oxo-3-{[2-(2-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)pentanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-1-benzyl-3-hydroxy-4-{(2S)-3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2-methylbutylcarbamate;   methyl(1S)-1-{[((1S,3S,4S)-1-benzyl-3-hydroxy-4-{[(2S)-2-(3-{[2-(methoxymethyl)-1,3-thiazol-4-yl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-1-benzyl-3-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2-methylbutylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(2S)-3-methyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)pentanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-4-{[(2S)-3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,2S,4S)-1-benzyl-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-2-hydroxy-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[((2S)-3-methyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-{[(2S)-3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(imidazo[1,5-a]pyridin-3-ylmethyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-({(2S)-2-[3-(imidazo[1,5-c]pyridin-3-ylmethyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-{[(2S)-3,3-dimethyl-2-(2-oxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)butanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4- yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-(2-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-(3-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-5-phenyl-1-[4-(3-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(3-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(4-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(2-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-(2-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-(3-methylbenzyl)-2-oxo-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(2-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(3-methoxybenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(4-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-3-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(3-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(4-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-3,3-dimethyl-2-[2-oxo-3-(2-pyridinylmethyl)-1-imidazolidinyl]butanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methyl-3-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2-methylbutylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{R2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4R)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-[((2S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3-methylpentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[((2S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-[((2S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3R,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3R,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{R2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-2-{3-[(6-tert-butyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-[((2S)-2-{3-[(6-isopropyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[425)-2-{3-[(6-tert-butyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-{R2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-2-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-2-[3-(2-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-2-[3-(4-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-({(2S)-2-[3-(3-aminobenzyl)-2-oxo-1-imidazolidinyl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-1-[4-(5-methyl-2-pyridinyl)benzyl]-5-phenylpentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[((2S)-2-{3-[(6-isopropyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}-3,3-dimethylbutanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-1-benzyl-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-[4-(2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-3-methyl-2-[2-oxo-3-(4-quinolinylmethyl)-1-imidazolidinyl]pentanoyl}amino)-5-phenylpentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(2-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(3-fluorobenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[2-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[4-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{2-oxo-3-[3-(trifluoromethyl)benzyl]imidazolidin-1-yl}butanoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-({(2S)-2-[3-(2-amino-3-methylbenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(3-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(4-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-({(2S)-2-[3-(2-hydroxybenzyl)-2-oxoimidazolidin-1-yl]-3,3-dimethylbutanoyl}amino)-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-3,3-dimethyl-2-(2-oxoimidazolidin-1-yl)butanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-{[(2S,3S)-3-methyl-2-(2-oxoimidazolidin-1-yl)pentanoyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-2-(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino 1-5-phenyl-3-(phosphonooxy)-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]methyl}-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-5-phenyl-3-(phosphonooxy)-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl (2S)-2-aminopropanoate;   methyl(1S)-1-({[(1R,3S,4S)-4-({(2S)-3,3-dimethyl-2-[3-({6-[1-methyl-1-(phosphonooxy)ethyl]pyridin-2-yl}methyl)-2-oxoimidazolidin-1-yl]butanoyl}amino)-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   (3S,5S,8S)-3-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-8-tert-butyl-7,10-dioxo-5-(4-pyridin-2-ylbenzyl)-2,11-dioxa-6,9-diazadodec-1-yl (dimethylamino)acetate;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl (phosphonooxy)methyl carbonate;   (5S,7S,10S)-5-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-10-tert-butyl-3,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-2,4,13-trioxa-8,11-diazatetradec-1-yl (dimethylamino)acetate;   (5S,8S,10S)-10-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-5-tert-butyl-3,6,12-trioxo-8-(4-pyridin-2-ylbenzyl)-2,11-dioxa-4,7-diazapentadecan-15-oic acid;   (1S,3S)-1-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-3-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-4-(4-pyridin-2-ylphenyl)butyl{[ethoxy(hydroxy)phosphoryl]oxy}methyl carbonate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-1-tert-butyl-10-hydroxy-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9,11-trioxa-3-aza-10-phosphatridec-1-ylcarbamate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-1-tert-butyl-10,10-dihydroxy-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9-dioxa-3-aza-10-phosphadec-1-ylcarbamate;   methyl(1S,4S,6S)-6-((1S)-1-{[(2S)-2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanoyl]amino}-2-phenylethyl)-1-tert-butyl-10,10-dihydroxy-8-methyl-10-oxido-2-oxo-4-(4-pyridin-2-ylbenzyl)-7,9-dioxa-3-aza-10-phosphadec-1-ylcarbamate; and   methyl(1S,4S,5S)-4-benzyl-1-tert-butyl-5-{(2S)-2-[((2S)-3,3-dimethyl-2-{3-[(6-methylpyridin-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoyl)amino]-3-phenylpropyl}-9,9-dihydroxy-9-oxido-2-oxo-6,8-dioxa-3-aza-9-phosphanon-1-ylcarbamate.   
   
   
       23 . The compound of  claim 1  having formula (IV) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, wherein: 
       X is O, S or NH; 
       R l  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R l  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 10  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 10  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a ,—SO 2 NR a , —SO 2OR   a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 10a ; 
       R 10a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 10a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, S(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is O or 1; 
       m is O or 1; 
       m′ is O or 1; 
       m″ is O or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is O or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; and 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 . 
     
   
   
       24 . The compound of  claim 1  having formula (V) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, wherein: 
       X is O, S or NH; 
       Y is O, S or NH; 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 11  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 11  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a ,—SO 2 NR a , —SO 2OR   a , —NR a R b , —N(R b )C(O)R a , —N(R b )SO 2 R a , —N(R b )SO 2 NR a R b , —N(R b )C(O)NR a R b , —N(R b )C(O)OR a , —C(O)R a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, formylalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)OR a , -alkylN(R b )SO 2 NR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkylC(O)R a , -alkylC(O)NR a R b  and R 11a ; 
       R 11a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 11a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, S(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is 0 or 1; 
       m is 0 or 1; 
       m′ is 0 or 1; 
       m″ is 0 or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is 0 or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; and 
       n is 1 or 2. 
     
   
   
       25 . The compound of  claim 24  wherein X is O and Y is O. 
   
   
       26 . The compound of  claim 24  wherein X is O, Y is O, R 4  is H and R 5  is OR 16 . 
   
   
       27 . The compound of  claim 24  wherein X is O, Y is O, R 4  is OR 16  and R 5  is H. 
   
   
       28 . The compound of  claim 24  wherein X is O, Y is O, R 4  is H, R 5  is OR 16  and R 2  is alkyl. 
   
   
       29 . The compound of  claim 24  wherein X is O, Y is O, R 4  is OR 16 , R 5  is H, and R 2  is alkyl. 
   
   
       30 . The compound of  claim 24  wherein X is O, Y is O, R 4  is H, R 5  is OR 16 , R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       31 . The compound of  claim 24  wherein X is O, Y is O, R 4  is OR 16 , R 5  is H, R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       32 . The compound of  claim 24 , or a pharmaceutically acceptable salt form, prodrug, or stereoisomer thereof, selected from the group consisting of:
 methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[415)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-2-hydroxy-4-[((2S)-3-methyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}pentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-[425)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-[((2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2,4-dioxo-1-imidazolidinyl}butanoyl)amino]-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-3-hydroxy-4-[((2S)-2-{3-[(2-isopropyl-1,3-thiazol-4-yl)methyl]-2,4-dioxo-1-imidazo lidinyl}-3-methylpentanoyl)amino]-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate; and   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(2,4-dioxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)-3-methylpentanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate.   
   
   
       33 . The compound of  claim 1  having formula (VI) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, wherein: 
       X is O, S or NH; 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 7  is —N(R b )C(O)OR a , alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl and heteroaryl are independently substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —OC(O)R a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 7a ; 
       R 7a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 7a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 12  is alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl or cycloalkenylalkyl; wherein each R 12  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of hydroxy, alkoxy and halo; 
       R 13  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle; wherein each R 13  is substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, halo, nitro, oxo, —OR a , —SR a , —SOR a , —SO 2 R a , —SO 2 NR a , —SO 2 OR a , —NR a R b , —N(R b )C(O)R a , —N(R b )C(O)OR a , —C(O)NR a R b , —C(O)OR a , haloalkyl, nitroalkyl, cynaoalkyl, -alkylOR a , -alkyl-O—P(O)(OR a )(OR a ), -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)NR a R b , -alkylN(R b )SO 2 R a , -alkylC(O)OR a , -alkyl-C(O)NR a R b  and R 13a ; 
       R 13a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 13a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, S(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is 0 or 1; 
       m is 0 or 1; 
       m′ is 0 or 1; 
       m″ is 0 or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is 0 or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; and 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 . 
     
   
   
       34 . The compound of  claim 33  wherein R 4  is H and R 5  is OR 16 . 
   
   
       35 . The compound of  claim 33  wherein R 4  is OR 16  and R 5  is H. 
   
   
       36 . The compound of  claim 33  wherein R 4  is H, R 5  is OR 16 , R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with O or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       37 . The compound of  claim 33  wherein R 4  is OR 16 , R 5  is H, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with O or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       38 . The compound of  claim 33 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, selected from the group consisting of:
 methyl(1S,4S,6S,7S,10S)-7-benzyl-1,10-ditert-butyl-6-hydroxy-13-methyl-2,9,12-trioxo-14-phenyl-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl(1S,4R,6S,7S,10S)-7-benzyl-1,10-ditert-butyl-6-hydroxy-13-methyl-2,9,12-trioxo-14-phenyl-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate;   methyl(1S,4S,6S,7S,10S)-7-benzyl-10-sec-butyl-1-tert-butyl-6-hydroxy-13-methyl-14-(2-methyl-1,3-thiazol-4-yl)-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate; and   methyl(1S,4S,5S,7S,10S)-7-benzyl-10-sec-butyl-1-tert-butyl-5-hydroxy-13-methyl-14-(2-methyl-1,3-thiazol-4-yl)-2,9,12-trioxo-4-[4-(2-pyridinyl)benzyl]-3,8,11,13-tetraazatetradec-1-ylcarbamate.   
   
   
       39 . The compound of  claim 1  having formula (VII) 
     
       
         
         
             
             
         
       
       or a pharmaceutically acceptable salt form or a stereoisomer thereof, wherein: 
       R 1  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R l  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2 , and R 1a ; 
       R 1a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 1a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 2  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a , —SR a , —SOR a , —SO 2 R a , —NR a R b , —NR b C(O)R a  —N(R b )C(O)OR a , —N(R a )C(═N)NR a R b , —N(R a )C(O)NR a R b , —C(O)NR a R b , —C(O)OR a  and R 2a ; 
       R 2a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 2a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 3  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NR a R b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 3a ; 
       R 3a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 3a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 4  is H and R 5  is OR 16 ; 
       or 
       R 5  is H and R 4  is OR 16 ; 
       or 
       R 4  and R 5  are —OR 16 ; 
       R 6  is alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, -alkylOR a , -alkylSR a , -alkylSOR a , -alkylSO 2 R a , -alkylNR a R b , -alkylN(R b )C(O)R a , -alkylN(R b )C(O)OR a , -alkylN(R a )C(═N)NRA b , -alkylN(R a )C(O)NR a R b , -alkylC(O)NR a R b , -alkylC(O)OR a , cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocycle, heterocyclealkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; wherein the cycloalkyl, cycloalkenyl, heterocycle, aryl, heteroaryl, cycloalkyl moiety of the cycloalkylalkyl, cycloalkenyl moiety of the cycloalkenylalkyl, heterocycle moiety of the heterocyclealkyl, heteroaryl moiety of the heteroarylalkyl and the aryl moiety of the arylalkyl are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R 6a ; 
       R 6a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 6a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, oxo, alkyl, alkenyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), and -alkylC(O)N(alkyl) 2 ; 
       R 14  is —OR a , -alkylOR a , aryl, heteroaryl or heterocycle; wherein the aryl, heteroaryl and heterocycle are independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —S(O) 2 NR a R b , —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkylC(O)N(alkyl) 2 ; 
       R 16  is hydrogen or R 15 ; 
       R 15  is 
     
     
       
         
         
             
             
         
       
       R 103  is C(R 105 ) 2 , O or —N(R 105 ); 
       R 104  is hydrogen, alkyl, haloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, 
       each M is independently selected from the group consisting of H, —N(R 105 ) 2 , alkyl, alkenyl, and R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl, other than the —CH 2  radical that is bound to Z, is optionally replaced by a heteroatom group selected from the group consisting of O, S, S(O), SO 2  and N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3 , NO 2  and phenyl; provided that when M is —N(R 105 ) 2 , Z 1  and Z 2  are —CH 2 ; 
       Z 1  is CH 2 , O, S, —N(R 105 ), or, when M is absent, H; 
       Z 2  is CH 2 , O, S or —N(R 105 ); 
       Q is O or S; 
       W is P or S; wherein when W is S, Z 1  and Z 2  are not S; 
       M′ is H, alkyl, alkenyl or R 106 ; wherein 1 to 4 —CH 2  radicals of the alkyl or alkenyl is optionally replaced by a heteroatom group selected from O, S, S(O), SO 2 , or N(R 105 ); and wherein any hydrogen in said alkyl, alkenyl or R 106  is optionally replaced with a substituent selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , —SO 2 N(R 105 ), —N(R 105 )C(O)R 105 , —C(O)R 105 , —SR 105 , —S(O)R 105 , —SO 2 R 105 , —OCF 3 , —SR 106 , —SOR 106 , —SO 2 R 106 , —N(R 105 )SO 2 R 105 , halo, —CF 3  and NO 2 ; 
       R 106  is a monocyclic or bicyclic ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2  and N(R 105 ); and wherein any of said ring system is substituted with 0, 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of hydroxy, alkyl, alkoxy, and —OC(O)alkyl; 
       each R 105  is independently selected from the group consisting of H or alkyl; wherein said alkyl is optionally substituted with a ring system selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocycle; wherein any of said heteroaryl and heterocycle ring systems contains one or more heteroatoms selected from the group consisting of O, N, S, SO, SO 2 , and N(R 105 ); and wherein any one of said ring systems is substituted with 0, 1, 2, 3 or 4 substituents selected from the group consisting of oxo, —OR 105 , —R 105 , —N(R 105 ) 2 , —N(R 105 )C(O)R 105 , —CN, —C(O)OR 105 , —C(O)N(R 105 ) 2 , halo and —CF 3 ; 
       each R 107  and R 108  are independently selected from the group consisting of hydrogen and alkyl; 
       q is 0 or 1; 
       m is 0 or 1; 
       m′ is 0 or 1; 
       m″ is 0 or 1; 
       r is 0, 1, 2, 3 or 4; 
       t is 0 or 1; 
       R a  and R b  at each occurrence are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocycle; wherein each R a  and R b , at each occurrence, is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of cyano, nitro, halo, oxo, hydroxy, alkoxy, alkyl, alkenyl, alkynyl, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; 
       alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of heteroaryl and heterocycle; wherein each of the heteroaryl and heterocycle is independently substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, formyl, nitro, halo, oxo, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , cyanoalkyl, formylalkyl, nitroalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl), -alkylC(O)N(alkyl) 2  and R c ; and 
       R c  is aryl, heteroaryl or heterocycle; wherein each R c  is independently substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkyl-NH 2 , -alkyl-N(H)(alkyl), -alkyl-N(alkyl) 2 , -alkyl-N(H)C(O)NH 2 , -alkyl-N(H)C(O)N(H)(alkyl), -alkyl-N(H)C(O)N(alkyl) 2 , -alkyl-C(O)OH, -alkyl-C(O)Oalkyl, -alkyl-C(O)NH 2 , -alkyl-C(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 . 
     
   
   
       40 . The compound of  claim 39  wherein R 4  is H, R 5  is OR 16  and R 2  is alkyl. 
   
   
       41 . The compound of  claim 39  wherein R 4  is OR 16 , R 5  is H and R 2  is alkyl. 
   
   
       42 . The compound of  claim 39  wherein R 4  is H, R 5  is OR 16 , R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       43 . The compound of  claim 39  wherein R 4  is OR 16 , R 5  is H, R 2  is alkyl, R 3  is arylalkyl wherein the aryl moiety of the arylalkyl is substituted with 0 or one R 3a , and R 3a  is aryl or heteroaryl. 
   
   
       44 . The compound of  claim 39 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, selected from the group consisting of:
 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl(1S,3S,4S)-1-benzyl-3-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-4-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl(1S,2S,4R)-1-benzyl-2-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   (3R,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-yl(1S,2S,4R)-1-benzyl-2-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-5-[4-(2-pyridinyl)phenyl]pentylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-4-{[(2,6-dimethylphenoxy)acetyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1R)-1-{[((1S,2S,4S)-4-{[4-(aminosulfonyl)benzoyl]amino}-1-benzyl-2-hydroxy-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-4-[(4-chloro-2-methylbenzoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-[(4-methoxy-2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1R,3S,4S)-3-hydroxy-4-[(2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-4-{[3-(aminosulfonyl)benzoyl]amino}-1-benzyl-2-hydroxy-5-phenylpentypamino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-[(3-chloro-2-methylbenzoyl)amino]-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-[(3-hydroxy-2-methylbenzoyl)amino]-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-3-hydroxy-4-{[(3-methylisoxazol-4-yl)carbonyl]amino}-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-({[(1S,3S,4S)-4-{[(3,5-dimethylisoxazol-4-yl)carbonyl]amino}-3-hydroxy-5-phenyl-1-(4-pyridin-2-ylbenzyl)pentyl]amino}carbonyl)-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-5-phenyl-4-[(thien-2-ylcarbonyl)amino]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,2S,4S)-1-benzyl-2-hydroxy-5-phenyl-4-[(thien-3-ylcarbonyl)amino]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(3-methylthien-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(5-methylthien-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate;   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-2-hydroxy-4-{[(1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-5-phenylpentyl)amino]carbonyl}-2,2-dimethylpropylcarbamate; and   methyl(1S)-1-{[((1S,2S,4S)-1-benzyl-4-{[(3,5-dimethylisoxazol-4-yl)carbonyl]amino}-2-hydroxy-5-phenylpentypamino]carbonyl}-2,2-dimethylpropylcarbamate.   
   
   
       45 . Methyl (1S)-1-[({(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate, or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of an ester, prodrug, salt of a prodrug, or combination thereof 
   
   
       46 . Methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate, or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of an ester, prodrug, salt of a prodrug, or combination thereof. 
   
   
       47 . Methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate, or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of an ester, prodrug, salt of a prodrug, or combination thereof 
   
   
       48 . Methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate, or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of an ester, prodrug, salt of a prodrug, or combination thereof. 
   
   
       49 . A pharmaceutical composition comprising a therapeutically effective amount of a compound or combination of compounds of  claim 1 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, and a pharmaceutically acceptable carrier. 
   
   
       50 . The pharmaceutical composition of  claim 49  wherein the compound of  claim 1  is selected from the group consisting of
 methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate,   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate, and   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate,   or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of a ester, prodrug, salt of a prodrug, or combination thereof, and a pharmaceutically acceptable carrier.   
   
   
       51 . A pharmaceutical composition comprising a therapeutically effective amount of a compound or combination of compounds of  claim 1 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof, and one, two, three, four, five or six agents selected from the group consisting of a second HIV protease inhibitor, a HIV reverse transcriptase inhibitor, an HIV entry/fusion inhibitor, an HIV integrase inhibitor and an HIV budding/maturation inhibitor, and a pharmaceutically acceptable carrier. 
   
   
       52 . The pharmaceutical composition of  claim 51  wherein the second HIV protease inhibitor is selected from the group consisting of ritonavir, lopinavir, saquinavir, amprenavir, fosamprenavir, nelfinavir, tipranavir, indinavir, atazanavir, TMC-126, TMC-114, mozenavir (DMP-450), JE-2147 (AG1776), L-756423, RO0334649, KNI-272, DPC-681, DPC-684 and GW640385X. 
   
   
       53 . The pharmaceutical composition of  claim 51  wherein the HIV reverse transcriptase inhibitor is selected from the group consisting of lamivudine, stavudine, zidovudine, abacavir, zalcitabine, didanosine, tenofovir, emtricitabine, amdoxovir, elvucitabine, alovudine, MIV-210, Racivir (±-FTC), D-D4FC (Reverset, DPC-817), SPD754, nevirapine, delavirdine, efavirenz, capravirine, emivirine, calanolide A, GW5634, BMS-56190 (DPC-083), DPC-961, MIV-150, TMC-120 and TMC-125. 
   
   
       54 . The pharmaceutical composition of  claim 51  wherein the HIV entry/fusion inhibitor is selected from the group consisting of enfuvirtide (T-20), T-1249, PRO 2000, PRO 542, PRO 140, AMD-3100, BMS-806, FP21399, GW873140, Schering C (SCH-C), Schering D (SCH-D), TNX-355 and UK-427857. 
   
   
       55 . The pharmaceutical composition of  claim 51  wherein the HIV integrase inhibitor is selected from the group consisting of S-1360, zintevir (AR-177), L-870812 and L-870810. 
   
   
       56 . The pharmaceutical composition of  claim 51  wherein the HIV budding/maturation inhibitor is PA-457. 
   
   
       57 . The pharmaceutical composition of  claim 51  wherein the compound of  claim 1  is selected from the group consisting of
 methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate;   methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate; and   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate, or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof   
   
   
       58 . A pharmaceutical composition comprising a therapeutically effective amount of a compound or combination of compounds of  claim 1 , or a pharmaceutically acceptable salt form, stereoisomer, ester, salt of an ester, prodrug, salt of a prodrug, or combination thereof, ritonavir or a pharmaceutically acceptable salt form or prodrug of ritonavir, and a pharmaceutically acceptable carrier. 
   
   
       59 . The pharmaceutical composition of  claim 58  wherein the compound of  claim 1  is selected from the group consisting of
 methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-ditert-butyl-5-hydroxy-2,9,12-trioxo-7-[4-(2-pyridinyl)benzyl]-13-oxa-3,8,11-triazatetradec-1-ylcarbamate; methyl(1S)-1-[({(1R,3S,4S)-3-hydroxy-4-{[(2S)-2-(3-{[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl}-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate;   methyl(1S)-1-[({(1S,3S,4S)-4-{[(2S)-2-(3-benzyl-2-oxo-1-imidazolidinyl)-3,3-dimethylbutanoyl]amino}-3-hydroxy-5-phenyl-1-[4-(2-pyridinyl)benzyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate; and   methyl(1S,4S,5S,7S,10S)-4-benzyl-1,10-bis(tert-butyl)-2,9,12-trioxo-5-[(phosphonooxy)methoxy]-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,8,11-triazatetradec-1-ylcarbamate,   or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof.   
   
   
       60 . A method of inhibiting the replication of an HIV virus comprising contacting said virus with a therapeutically effective amount of a compound or combination of compounds of any one of  claims 1 ,  45 ,  46 ,  47  and  48 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof. 
   
   
       61 . A method of inhibiting HIV protease comprising contacting said HIV protease with a therapeutically effective amount of a compound or combination of compounds of any one of  claims 1 ,  45 ,  46 ,  47  and  48 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof. 
   
   
       62 . A method for treating or preventing an HIV infection comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound or combination of compounds of any one of  claims 1 ,  45 ,  46 ,  47  and  48 , or a pharmaceutically acceptable salt form, prodrug or stereoisomer thereof. 
   
   
       63 . A method for treating or preventing an HIV infection comprising administering to a patient in need of such treatment a pharmaceutical composition of any one of  claims 49 ,  50 ,  51 ,  52 ,  53 ,  54 ,  55 ,  56 ,  57 ,  58  and  59 . 
   
   
       64 . A process of preparing a compound of formula (XVIII) 
     
       
         
         
             
             
         
       
       wherein 
       X 1  is CH or N; 
       X 2  is CH or N; 
       X 3  is CH or N; provided only one of X 1 , X 2 , X 3  is N and the other two are CH; 
       R 112  is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl heterocyle, aryl or heteroaryl; wherein each R 112  is substituted with 0, 1 or 2 substituents independently selected from the group consisting of halo, —OR a′ , —SR a′ , —SOR a′ , —SO 2 R a′ , —NR a′ R b′ , —N(R b′ )C(O)R a′ —N(R b′ )C(O)OR a′ , —N(R b′ )C(═N)NR a′ R b′ , —N(R b′ )C(O)NR a′ R b′ , —C(O)NR a′ R b′ , —C(O)OR a′  and R 112a ; 
       R 112a  is cycloalkyl, cycloalkenyl, heterocycle, aryl or heteroaryl; wherein each R 112a  is substituted with 0, 1, 2, 3 or 4 substituents independently selected from the group consisting of cyano, halo, nitro, oxo, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, —NH 2 , —N(H)(alkyl), —N(alkyl) 2 , —SH, —S(alkyl), —SO 2 (alkyl), —N(H)C(O)alkyl, —N(alkyl)C(O)alkyl, —N(H)C(O)NH 2 , —N(H)C(O)N(H)(alkyl), —N(H)C(O)N(alkyl) 2 , —C(O)OH, —C(O)Oalkyl, —C(O)NH 2 , —C(O)N(H)(alkyl), —C(O)N(alkyl) 2 , haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylNH 2 , -alkylN(H)(alkyl), -alkylN(alkyl) 2 , -alkylN(H)C(O)NH 2 , -alkylN(H)C(O)N(H)(alkyl), -alkylN(H)C(O)N(alkyl) 2 , -alkylC(O)OH, -alkylC(O)Oalkyl, -alkylC(O)NH 2 , -alkylC(O)N(H)(alkyl) and -alkyl-C(O)N(alkyl) 2 ; 
       R 111  is C 1 -C 6  alkyl or phenylmethyl; and 
       R a′  and R b′  are each independently selected from the group consisting of hydrogen and alkyl. 
       wherein the process comprises the steps of:
 (a) contacting a compound of formula (i) 
 
     
     
       
         
         
             
             
         
       
       with potassium tert-butoxide and n-butyl lithium in a first solvent;
 (b) contacting a first base with ketonitrile of formula (ii) 
 
     
     
       
         
         
             
             
         
       
       wherein P 1  and P 2  are nitrogen protecting group and P 1  and P 2  can be the same or different, in the first solvent;
 (c) contacting the product of step (b) with the product of step (a) to provide a compound of formula (iii) 
 
     
     
       
         
         
             
             
         
       
       
         (d) contacting the compound of formula (iii) with a first reducing agent and an acid in a second solvent; 
         (e) contacting the product of step (d) in the second solvent with a second reducing agent, to provide a compound of formula (iv): 
       
     
     
       
         
         
             
             
         
       
       
         (f) contacting the compound of formula (iv) with a hydrogen source and a catalyst in a third solvent to provide a compound of formula (v): 
       
     
     
       
         
         
             
             
         
       
       and
 (g) contacting the compound of formula (v) with a compound of formula (vi), 
 
     
     
       
         
         
             
             
         
       
       a coupling reagent and a second base in a fourth solvent to provide the compound of formula (XVIII).