US2010249924A1PendingUtilityA1

Bioerodible matrix for tissue involvement

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Assignee: ALLERGAN INCPriority: Mar 27, 2009Filed: Feb 12, 2010Published: Sep 30, 2010
Est. expiryMar 27, 2029(~2.7 yrs left)· nominal 20-yr term from priority
Inventors:Thomas E. PowellDennis E. Van Epps
A61L 27/18A61F 2/12A61L 2430/04A61L 27/58A61L 27/3834A61L 27/34A61P 17/00A61L 2420/06A61L 27/3886A61L 27/56A61L 27/3804A61L 27/3604
55
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Claims

Abstract

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

Claims

exact text as granted — not AI-modified
1 . A method of promoting tissue generation in a patient, comprising:
 implanting a matrix in a target area of a patient, the matrix comprising a resorbable or bioerodible polymer component and a cellular component.   
     
     
         2 . The method of  claim 1  wherein the polymer component is a porous polyurethane polymer. 
     
     
         3 . The method of  claim 1  wherein the polymer component has a porosity of from about 20 microns to about 350 microns. 
     
     
         4 . The method of  claim 1  wherein the polymer component comprises a polyurethane polymer. 
     
     
         5 . The method of  claim 1  wherein the polymer component comprises polycarolactone soft segments. 
     
     
         6 . The method of  claim 1  wherein the cellular component comprises stem cells. 
     
     
         7 . The method of  claim 1  wherein the cellular component comprises adipose cells. 
     
     
         8 . The method of  claim 1  wherein the cellular component comprises stem cells and adipose cells. 
     
     
         9 . A method of augmenting or reconstructing a human breast comprising:
 implanting a silicone or saline filled breast implant into a patient; and   implanting a matrix at the site of the breast implant, the matrix comprising a resorbable or bioerodible polymer component and a cellular component.   
     
     
         10 . The method of  claim 9  wherein the matrix is implanted so as to support a lower pole position of the breast implant. 
     
     
         11 . The method of  claim 9  further comprising the step of at least partially covering the breast implant with the matrix prior to the steps of implanting. 
     
     
         12 . The method of  claim 9  further comprising the step of at least partially enveloping the breast implant with the matrix prior to the steps of implanting. 
     
     
         13 . The method of  claim 9  wherein the matrix is structured to promote tissue ingrowth. 
     
     
         14 . The method of  claim 9  wherein the polymer component is a porous polyurethane polymer. 
     
     
         15 . The method of  claim 9  wherein the polymer component has a porosity of from about 20 microns to about 350 microns. 
     
     
         16 . The method of  claim 9  wherein the polymer component comprises a polyurethane polymer. 
     
     
         17 . The method of  claim 9  wherein the polymer component comprises polycarolactone soft segments. 
     
     
         18 . The method of  claim 9  wherein the cellular component comprises stem cells. 
     
     
         19 . The method of  claim 9  wherein the cellular component comprises adipose cells. 
     
     
         20 . The method of  claim 9  wherein the cellular component comprises stem cells and adipose cells. 
     
     
         21 . The method of  claim 1  wherein the resorbable or bioerodible polymer. component comprises silk. 
     
     
         22 . A medical implant for promoting tissue generation in a patient, the medical implant comprising a matrix including a resorbable or bioerodible polymer component and a cellular component. 
     
     
         23 . The medical implant of  claim 22  wherein the resorbable or bioerodible polymer component comprises silk.

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