Pharmaceutical composition for diabetic nephropathy and its preparation and application

Abstract

The invention relates to application of 4,4′-diphenylmethane-bis(methyl)carbamates (DPMC) extracted and isolated from Cortex Mori and preparation of medicine for diabetic nephropathy. The pharmaceutical composition is made up of DPMC as active ingredient and the normal drug carriers, and the weight percentage of active ingredient is 0.1-99.5%. For the remarkable effect of prevention and cure for diabetic nephropathy and convenience for use, it will be a new facultative drug for patients.

1 . A pharmaceutical composition for diabetic nephropathy, wherein: the pharmaceutical composition is made up of 4,4′-diphenylmethane-bis(methyl)carbamates as active ingredient, and the conventional drug carrier; the active ingredient is in a percentage of 0.1-99.5% by weight. 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the active ingredient is in a percentage of 5-70% by weight. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the conventional drug carrier comprises at least one of diluent, excipient, filler, adhesive, wetting agent, disintegrant, absorption enhancer, surfactant, adsorption carrier, lubricant, flavor agent and sweetener, wherein the excipient is water; the filter is starch, sucrose or lactose; the adhesive at least one selected from a group consisting of cellulose derivative, alginate, gelatin and polyvinylpyrrolidone; the wetting agent is glycerine; the disintegrant is agar, calcium carbonate or sodium bicarbonate; the absorption enhancer is quaternary ammonium compound; the surfactant is palmityl alcohol; the adsorption carrier is kaolin clay or soap clay; the lubricant is talc, calcium stearate, magnesium stearate or polyethylene glycol. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the pharmaceutical composition can be prepared into a clinical dosage form such as pellet, drug granules, pills, capsule, or liquid formulation. 
     
     
         5 . A method for preparing the pharmaceutical composition of  claim 1 , comprising: mixing the 4,4′-diphenylmethane-bis(methyl)carbamates with the conventional drug carrier; preparing according the specific preparation process to obtain the pharmaceutical composition. 
     
     
         6 . The method of  claim 5 , wherein the method of preparing the 4,4′-diphenylmethane-bis(methyl)carbamates is as follows:
 D. triturate the dry root cortex of Cortex Mori to power, add water and extract under reflux, combine the extract, concentrate to a necessary volume under vacuum;   E. add to the macroporous resin, elute with water, following with 95% EtOH, collect the elution of 95% EtOH and concentrate under vacuum;   F. add to the silica gel and elute with petroleum, petroleum-acetic ether 100:1, petroleum-acetic ether 50:1, respectively, and a colorless lamellar crystal is attained from the elution of petroleum-acetic ether 50:1.   
     
     
         7 . Use of 4,4′-diphenylmethane-bis(methyl)carbamates in preparing a pharmaceutical composition for diabetic nephropathy.