Cytokine receptor zcytor17 multimers

Abstract

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

1 . An antibody or antibody fragment that specifically binds to a multimeric or heterodimeric cytokine receptor comprising a first cytokine receptor comprising amino acid residues 20-519 of SEQ ID NO:111 and a second cytokine receptor comprising amino acid residues 28-739 of SEQ ID NO:7. 
     
     
         2 . The antibody or antibody fragment of  claim 1  wherein the antibody or antibody fragment is selected from the group consisting of a polyclonal antibody, a murine monoclonal antibody, a human monoclonal antibody, a humanized antibody derived from a murine monoclonal antibody, a chimeric antibody, Fab fragment, F(ab′)2 fragment, and a single chain antibody. 
     
     
         3 . The antibody or antibody fragment of  claim 1  wherein the antibody or antibody fragment further comprises a radionuclide, enzyme, substrate, cofactor, fluorescent marker, chemiluminescent marker, peptide tag, magnetic particle, drug, or toxin. 
     
     
         4 . A composition comprising the antibody or antibody fragment of  claim 1  and a pharmaceutically acceptable vehicle.