Isoflavone metabolites

Abstract

There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R 1 and R 2 is selected from H, OH and OCH 3 , and the other of R 1 and R 2 is selected from OH and OCH 3 ; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R 1 , R 2 and R 3 , R 4 are both OH; R 5 is selected from OH and OCH 3 ; and denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.

1 - 22 . (canceled) 
     
     
         23 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of at least one condition selected from the group consisting of: menopausal syndrome: osteoporosis; rheumatic diseases; atherosclerosis; premenstrual syndrome; coronary artery spasm; vascular diseases; Buergers Disease; migraine headaches; hypertension; benign prostatic hypertrophy; cancer; Alzheimer's disease; inflammatory diseases; baldness; psoriasis; acne; and diseases associated with oxidant stress, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         24 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of a hormone-dependent condition, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         25 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of cancer, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         26 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of at least one condition selected from the group consisting of: menopausal syndrome: osteoporosis; rheumatic diseases; atherosclerosis; premenstrual syndrome; coronary artery spasm; vascular diseases; Buergers Disease; migraine headaches; hypertension; benign prostatic hypertrophy; cancer; Alzheimer's disease; inflammatory diseases; baldness; psoriasis; acne; and diseases associated with oxidant stress, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         27 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of a hormone-dependent condition, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         28 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of cancer, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         29 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of at least one condition selected from the group consisting of: menopausal syndrome: osteoporosis; rheumatic diseases; atherosclerosis; premenstrual syndrome; coronary artery spasm; vascular diseases; Buergers Disease; migraine headaches; hypertension; benign prostatic hypertrophy; cancer; Alzheimer's disease; inflammatory diseases; baldness; psoriasis; acne; and diseases associated with oxidant stress, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         30 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of a hormone-dependent condition, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         31 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of cancer, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         32 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of at least one condition selected from the group consisting of: menopausal syndrome: osteoporosis; rheumatic diseases; atherosclerosis; premenstrual syndrome; coronary artery spasm; vascular diseases; Buergers Disease; migraine headaches; hypertension; benign prostatic hypertrophy; cancer; Alzheimer's disease; inflammatory diseases; baldness; psoriasis; acne; and diseases associated with oxidant stress, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         33 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of a hormone-dependent condition, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. 
     
     
         34 . A method of treatment, amelioration, defense against, prophylaxis, and prevention of cancer, said method comprising administering an effective amount of at least one compound having the structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.