Application of american ginseng to enhance neurocognitive function

Abstract

Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

1 . A method of enhancing cognitive performance by administering an amount of American Ginseng effective to treat a subject. 
     
     
         2 . The method of  claim 1  wherein the amount American Ginseng administered comprises between about 5 mg and about 50 mg total ginsenosides. 
     
     
         3 . The method of  claim 1  wherein the cognitive performance is Attention, measured using the Choice Reaction Time test. 
     
     
         4 . The method of  claim 3  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides. 
     
     
         5 . The method of  claim 4  wherein the amount of American Ginseng is administered more than about 6 hours before desired results. 
     
     
         6 . The method of  claim 3  wherein the amount of American Ginseng administered comprises about 23.30 mg total ginsenosides. 
     
     
         7 . The method of  claim 6  wherein the amount of American Ginseng is administered more than about 1 hour before desired results. 
     
     
         8 . The method of  claim 6  wherein the amount of American Ginseng is administered more than about 6 hours before desired results. 
     
     
         9 . The method of  claim 1  wherein the cognitive performance is Working Memory, measured using the Immediate Word Recall test. 
     
     
         10 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 23.30 mg total ginsenosides. 
     
     
         11 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 46.60 mg total ginsenosides. 
     
     
         12 . The method of  claim 11  wherein the amount of American Ginseng is administered more than about 1 hour before desired results. 
     
     
         13 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides. 
     
     
         14 . The method of  claim 13  wherein the amount of American Ginseng is administered more than about 6 hours before desired results. 
     
     
         15 . The method of  claim 1  wherein the cognitive performance is Working Memory, measured using the Numeric Working Memory test. 
     
     
         16 . The method of  claim 15  wherein the amount of American Ginseng administered comprises about 23.30 mg total ginsenosides. 
     
     
         17 . The method of  claim 1  wherein the cognitive performance is Working Memory, measured using the Alphabetic Working Memory test. 
     
     
         18 . The method of  claim 17  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides. 
     
     
         19 . The method of  claim 17  wherein the amount of American Ginseng administered comprises about 46.60 mg total ginsenosides. 
     
     
         20 . The method of  claim 1  wherein the cognitive performance is spatial span. 
     
     
         21 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides. 
     
     
         22 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 23.30 mg total ginsenosides. 
     
     
         23 . The method of  claim 9  wherein the amount of American Ginseng administered comprises about 46.60 mg total ginsenosides. 
     
     
         24 . The method of  claims 1 ,  2 ,  3 ,  9 ,  15 ,  17 , or  20  wherein the amount of American Ginseng administered also improves calmness. 
     
     
         25 . The method of  claim 23  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides, and the American Ginseng is administered more than about 3 hour before desired results. 
     
     
         26 . The method of  claim 23  wherein the amount of American Ginseng administered comprises about 11.65 mg total ginsenosides, and the American Ginseng is administered more than about 6 hour before desired results. 
     
     
         27 . The method of  claim 1  wherein the American Ginseng comprises ginsenosides in the proportion of about 3 parts Rg 1 , about 22 parts Re, about 61 parts Rb 1 , about 20 parts Rc, about 3 parts Rb 2 , and about 16 parts Rd.