US2010279406A1PendingUtilityA1

Alteration of tumor growth using zinc finger proteins

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Assignee: SANGAMO BIOSCIENCES INCPriority: Jan 12, 1999Filed: Sep 20, 2006Published: Nov 4, 2010
Est. expiryJan 12, 2019(expired)· nominal 20-yr term from priority
Inventors:George N. Cox, IiiCasey C. CaseStephen P. EisenbergEric JarvisSharon Kaye Spratt
A61P 9/10A61P 7/00A61P 7/06A61P 37/00A61P 3/06A61P 9/00A61P 43/00A61P 25/28A61P 35/00A61P 27/02A61P 31/10A61P 31/12A61P 31/04A61P 31/18A61P 29/00A61P 33/02A61P 31/00C12N 2830/002C12N 15/67C12N 2830/85C12N 2830/005A61P 19/02C12N 15/8216C12N 15/63A01K 67/0275C07K 2319/00A61P 21/04C07K 2319/71A61P 11/00C12N 2830/008A61K 48/00G01N 33/5091A61K 48/005A61P 21/00C12N 15/85C07K 14/52C07K 2319/81A61P 17/06C07K 14/47C12Q 1/66A01K 2217/05C12Q 1/6897
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Claims

Abstract

The present invention provides methods for altering tumor growth using zinc finger proteins.

Claims

exact text as granted — not AI-modified
1 . A method for suppressing tumor growth, wherein the method comprises:
 expressing an engineered zinc finger protein in a tumor cell;   under conditions in which the engineered zinc finger protein binds to a target site in an endogenous cellular gene in the tumor cell and modulates expression of the endogenous cellular gene such that tumor growth is suppressed.   
     
     
         2 . (canceled) 
     
     
         3 . The method of  claim 1 , wherein the endogenous gene is a tumor suppressor gene and wherein the engineered zinc finger protein activates expression of the tumor suppressor gene. 
     
     
         4 . The method of  claim 3 , wherein the tumor suppressor gene is p53. 
     
     
         5 . The method of  claim 1 , wherein the zinc finger protein further comprises a transcriptional regulatory domain.

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