Mammalian MDM2 Binding Proteins and Uses Thereof

Abstract

Isolated nucleic acid sequences encoding mammalian MDM 2 binding protein and polypeptide sequences for the mammalian MDM 2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and antibodies targeted to these proteins. In addition, methods and compositions for modulating the G 1 phase of the cell cycle via altering expression and/or activity of a mammalian MDM 2 binding protein are provided.

1 . A composition for modulating the G 1  phase of cell cycling comprising a compound which alters levels or activity of a mammalian MDM2 binding protein. 
     
     
         2 . The composition of  claim 1  wherein the compound is an antisense agent targeted to a gene encoding a mammalian MDM2 binding protein, a ribozyme targeted to a gene encoding a mammalian MDM2 binding protein, a peptide mimic of a mammalian MDM2 binding protein or a modulator of MDM2 expression.