Immunology Treatment for Biofilms

Abstract

The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P. gingivalis infection comprising administering to the subject a composition of the invention

1 . A composition for use in raising an immune response to  P. gingivalis  in a subject, the composition comprising an amount effective to raise an immune response of at least one antigenic or immunogenic portion of a polypeptide corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. 
     
     
         2 . A composition of  claim 1  wherein the portion has an amino acid sequence that is substantially identical to at least 50 amino acids of one of the polypeptides. 
     
     
         3 . A composition of  claim 2  wherein the polypeptide corresponds to an accession number selected from the group consisting of AAQ65462, AAQ66991, AAQ65561 and AAQ66831. 
     
     
         4 . A composition of  claim 2  wherein the polypeptide corresponds to accession number AAQ65742. 
     
     
         5 . A composition for use in raising an immune response to  P. gingivalis  in a subject, the composition comprising amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids of a polypeptide expressed by  P. gingivalis  and that is predicted by the CELLO program to be extracellular. 
     
     
         6 . A composition for use in raising an immune response to  P. gingivalis  in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence selected substantially identical to at least 50 amino acids of a polypeptide that causes an immune response in a mouse or a rabbit. 
     
     
         7 . A method of preventing, inhibiting or treating a subject for periodontal disease comprising administering to the subject an effective amount of composition according to  claim 1 . 
     
     
         8 . A method of preventing or treating a subject for  P. gingivalis  infection comprising administering to the subject a composition according to  claim 1 . 
     
     
         9 . An antibody raised against an antigenic region of a polypeptide having an amino acid sequence, the sequence being substantially identical to at least 50 amino acids of one of the polypeptides corresponding to accession numbers AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. 
     
     
         10 . An antibody of  claim 9  wherein the polypeptide corresponds to an accession number selected from the group consisting of AAQ65462, AAQ66991, AAQ65561 and AAQ66831. 
     
     
         11 . An antibody of  claim 9  wherein the polypeptide corresponds to an accession number selected from the group consisting of AAQ65742.