Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors

Abstract

Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.

1 .- 26 . (canceled) 
     
     
         27 . Compound of formula (I) 
       
         
           
           
               
               
           
         
         wherein R1 is H, R2 is hydroxymethyl and R3 is methoxy, or its prodrugs or pharmaceutically acceptable salts. 
       
     
     
         28 . Pharmaceutical compositions comprising the compound as defined in  claim 27  as active principle. 
     
     
         29 . Pharmaceutical compositions according to  claim 28 , further comprising pharmaceutically acceptable excipients and/or diluents. 
     
     
         30 . Method for the treatment of diseases associated with an increased activity of matrix metalloproteinases wherein a compound as defined in claim  26  is used. 
     
     
         31 . Method according to  claim 30 , wherein said matrix metalloproteinase is the metalloelastase of macrophages (MMP-12). 
     
     
         32 . Method according to  claim 31 , wherein said disease associated with an increased activity of matrix metalloproteinase is pulmonary emphysema. 
     
     
         33 . Method according to  claim 30 , wherein said matrix metalloproteinase are the neutrophil collagenase and collagenase 3 (MMP-8 and MMP-13 respectively). 
     
     
         34 . Method according to  claim 33 , wherein said disease associated with an increased activity of matrix metalloproteinase is periodontitis.