US2010303925A1PendingUtilityA1

Remineralisation of calcified tissue

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Assignee: UNIV DUNDEEPriority: Apr 21, 2008Filed: Apr 21, 2009Published: Dec 2, 2010
Est. expiryApr 21, 2028(~1.8 yrs left)· nominal 20-yr term from priority
Inventors:Nigel Berry PittsChristopher LongbottomJoseph CraystonDmitri GrinevIan Mcewing Young
A61P 1/02A61K 6/838A61K 6/864A61K 6/20A61K 8/24A61K 33/06C08L 89/005A61K 2800/83A61K 33/42A61Q 11/00A61L 27/22C08L 1/284C08L 29/14A61K 8/19C08L 29/04A61K 8/21A61N 1/325A61K 41/0047A61N 1/0548C08L 31/04C08L 71/02A61L 27/12A61K 2300/00A61K 8/64A61C 19/066A61C 19/063C08L 33/14
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Claims

Abstract

The disclosure concerns cosmetic and therapeutic treatment of tissue, such as tooth, to effect, for instance, whitening and tissue re-building through mineralisation and including kits for use in the methods.

Claims

exact text as granted — not AI-modified
1 . A method of remineralising tissue which comprises pre-conditioning the tissue to remove protein and/or lipids and then applying a remineralising agent whilst separately, sequentially or simultaneously applying iontophoresis. 
     
     
         2 . A method according to  claim 1 , wherein the remineralising agent is a source of phosphate, calcium and water. 
     
     
         3 . A method according to  claim 1 , wherein the method further comprises the remineralisation of hypo-mineralised or de-mineralised tooth. 
     
     
         4 . A method according to  claim 1 , wherein the method further comprises cosmetic treatment of the tooth. 
     
     
         5 . A method according to  claim 4 , wherein the method further comprises tooth lightening or whitening. 
     
     
         6 . A method according to  claim 1 , wherein the method further comprises preventional treatment of tooth erosion. 
     
     
         7 . A method according to  claim 1 , wherein the method further comprises the remineralisation of bone. 
     
     
         8 . A method according to  claim 1 , wherein the remineralising agent comprises casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). 
     
     
         9 . A method according to  claim 1 , wherein the remineralising agent is a fluoride-containing agent. 
     
     
         10 . A method according to  claim 8 , wherein the fluoride-containing agent is casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP). 
     
     
         11 . A method according to  claim 1 , wherein the remineralising agent includes one or more remineralisation enhancers. 
     
     
         12 . A method according to  claim 11  wherein the remineralising agent includes at least two remineralisation enhancers wherein one of the enhancers is a source of calcium ions and the other is a source of phosphate ions. 
     
     
         13 . A method according to  claim 12 , wherein the ratio of calcium:phosphate in the remineralising agent is between 1:1 and 22:10. 
     
     
         14 . A method according to  claim 13  wherein the ratio of calcium:phosphate is about 10:6. 
     
     
         15 . A method according to  claim 12 , wherein the ratio of calcium:phosphate in the remineralising agent is between about 3:2 and 22:10. 
     
     
         16 . A method according to  claim 12 , wherein the ratio of calcium:phosphate in the remineralising agent is between is greater than 1:1 but less than 3:2. 
     
     
         17 . A method according to  claim 11 , wherein the remineralisation enhancer is strontium. 
     
     
         18 . A method according to  claim 1 , wherein the preconditioning step is performed, with or without the application of iontophoresis, prior to application of the remineralising agent/iontophoresis. 
     
     
         19 . A method according to  claim 1 , wherein the pre-conditioning step comprises treatment with an acid. 
     
     
         20 . A method according to  claim 19 , wherein the acid is phosphoric acid. 
     
     
         21 . A method according to  claim 1 , wherein the pre-conditioning step comprises treatment with a hypochlorite. 
     
     
         22 . A method according to  claim 1 , wherein the method further comprises the treatment or alleviation of dental caries and/or dental fluorosis in a mammal. 
     
     
         23 . A method according to  claim 1 , wherein the method further comprises the remineralising of hypo-mineralised or de-mineralised (carious) dentine. 
     
     
         24 . A remineralising agent for use in iontophoretic remineralising treatment of tissue which has been subject to pre-conditioning to remove protein and/or lipids, the remineralising agent being a source of both phosphate and calcium. 
     
     
         25 . A remineralising agent according to  claim 24 , wherein the agent comprises casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP). 
     
     
         26 . A kit for use in iontophoretic remineralising treatment of tissue comprising a pre-conditioning agent and a remineralising agent.

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