Method for tissue regeneration

Abstract

The invention relates to DNA-sequences, their use and the use of DNA-sequences of the MAG gene or genes encoding the high mobility group proteins, agents for the treatment of various diseases including tumors, influencing the development of the vascular system, as well as for contraception and tissue regeneration, and appropriate kits and processes. The sequences, agents, uses, kits and processes enable the specific influencing of molecular mechanisms that jointly form the basis for various diseases, the development of the vascular system, the contraception and the regeneration of tissue. Thus, the disadvantages associated with other agents or processes are decreased.

1 . A method for regenerating tissue, comprising administering to said tissue a translation product of a nucleic acid sequence wherein said nucleic acid sequence is an HMGI gene. 
     
     
         2 . A method according to  claim 1 , wherein tissue regeneration is performed in situ. 
     
     
         3 . A method according to  claim 2 , wherein a mesenchymal tissue is selected from the group consisting of cartilage tissue, muscle tissue, fatty or adipose tissue, connective tissue and supporting tissue. 
     
     
         4 . A method according to  claim 1 , wherein said translation product is administered via an encapsulation technique to said tissue. 
     
     
         5 . A method according to  claim 1 , wherein tissue is regenerated by the steps comprising:
 carrying out the administering step to at least one cell to provide at least one administered cell;   co-culturing said at least one administered cell with cells of said tissue in vitro; and   propagating said co-cultured cells to obtain regenerated tissue.   
     
     
         6 . A method according  claim 1 , wherein the tissue to be regenerated is mesenchymal tissue. 
     
     
         7 . A method according to  claim 6 , wherein the mesenchymal tissue is selected from the group consisting of cartilage tissue, muscle tissue, fatty or adipose tissue, connective tissue and supporting tissue. 
     
     
         8 . The method of  claim 5 , wherein the administered cell and the cells of said tissue are from the same tissue. 
     
     
         9 . The method of  claim 5 , wherein the administered cell is a tumor cell. 
     
     
         10 . The method of  claim 9 , wherein the regenerated tissue is cartilage tissue. 
     
     
         11 . The method of  claim 5 , wherein the tissue is a mesenchymal tissue which is selected from the group consisting of cartilage tissue, muscle tissue, fatty or adipose tissue, connective tissue and supporting tissue.