Use of inhibitors of jun n-terminal kinases to treat glaucoma

Abstract

Compositions and methods for lowering IOP and/or providing neuroprotection are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK) to lower IOP and/or provide neuroprotection.

1 . A method for lowering intraocular pressure and providing neuroprotection in a human patient identified as having glaucoma, said method comprising administering to the human patient a composition comprising a therapeutically effective amount of a JNK inhibitor and a pharmaceutically acceptable vehicle, wherein the JNK inhibitor is selected from the group consisting of: SP600125, 
       
         
           
           
               
               
           
         
       
     
     
         2 . A method according to  claim 1 , wherein the composition is an oral formulation. 
     
     
         3 . A method according to  claim 1 , wherein the composition is a topical ophthalmic, surgical irrigating solution or an intraocular formulation.