Therapeutic amine-arylsulfonamide conjugate compounds

Abstract

Therapeutic amine-arylsulfonamide conjugate compounds, of the general formula: wherein R′ is [D-W-], hydroxyl, or alkoxyl; R″ is independently [D-W′-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur; D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; W and W′ are a chemical bond or linker; wherein either R′ is [D-W-] or at least one R″ is [D-W′-], and pharmaceutically acceptable esters, amides, salts or solvates thereof, pharmaceutical compositions containing same, methods for their preparation, and their use in treating psychiatric, neurologic and metabolic disorders are disclosed.

1 . A therapeutic amine-arylsulfonamide conjugate compound, comprising structure (I): 
       
         
           
           
               
               
           
         
         wherein 
         R′ is [D-W-], hydroxyl, or alkoxyl; 
         R″ is independently [D-W′-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur; 
         D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; 
         W and W′ are a chemical bond or linker; 
         wherein either R′ is [D-W-] or at least one R″ is [D-W′-]; and pharmaceutically acceptable esters, amides, salts or solvates thereof. 
       
     
     
         2 . The therapeutic amine-arylsulfonamide conjugate compound, wherein the therapeutic amine radical is derived from amines selected from the group consisting of: manifaxine; 2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethanol; (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol; radafaxine; 2-(1-(3-chlorobenzoyl)-(R,S)-ethylamino)-2,2-dimethylethanol; bupropion; citalopram; escitalopram; paroxetine; fluoxetine; fluvoxamine; sertraline; phenelzine; tranylcypromine; amitriptyline; amoxapine; clomipramine; desipramine; doxepine; imipramine; nortryptyline; protriptyline; trimipramine; maprotiline; mirtazapine; duloxetine; nefazodone; trazodone; and venlafaxine; 
     
     
         3 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein the R″ is cycloalkyl, alkenyl, alkynyl, or aryl optionally substituted with alkyl, hydroxy, hydroxyalkyl, alkoxy, amino, mercapto, nitro, or cyano. 
     
     
         4 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein the R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur, the ring being optionally substituted by hydroxy, hydroxyalkyl, oxo, alkyl, haloalkyl, and/or haloalkoxy. 
     
     
         5 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein the linker W is selected from the group consisting of:
 —CHRO—;   —C(O)OCHRO—;   —C(O)OCHROC(O)R 1 O—;   —C(O)R 1 O—;   —CHROC(O)R 1 O—;   —C(O)R 1 OC(O)R 1 O—; and   —CHROC(O)R 1 OC(O)R 1 O—;   
       wherein 
       R 1  is, independently,
 —(CH 2 ) n —; 
 —(CH 2 ) o CHY(CH 2 ) n —; 
 —(CH 2 ) o CH═CH(CH 2 ) n —; 
 —(CH 2 ) n O(CH 2 ) n —; 
 —(CH 2 ) n NR(CH 2 ) n —; 
 —(CH 2 ) o C═C(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n CHY(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n CH═CH(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n O(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n NR(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n S(O) m (CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n C≡C(CH 2 ) n — or; 
 a 5- or 6-membered aromatic ring diradical optionally containing 1 or more heteroatoms independently selected from oxygen, nitrogen and sulfur, the 5- or 6-membered aromatic ring diradical optionally substituted by hydroxy, hydroxyalkyl, halogen, amino, alkyl, or alkoxyalkyl; 
 
       R is independently hydrogen, alkyl, cycloalkyl or aryl; 
       Y is a halogen; 
       n is independently 1-8; 
       m is 0, 1, or 2; and 
       o is 0-8. 
     
     
         6 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein the linker W′ is selected from the group consisting of:
 —CHROC(O)R 1 C(O)OCHR—;   —C(O)R 1 C(O)OCHR—;   —C(O)OCHROC(O)R 1 C(O)OCHR—;   —CHROC(O)R 1 C(O)OCHROC(O)—;   —C(O)R 1 C(O)OCHROC(O)—; and   —C(O)OCHROC(O)R 1 C(O)OCHROC(O)—;   
       wherein 
       R 1  is, independently,
 —(CH 2 ) n —; 
 —(CH 2 ) o CHY(CH 2 ) n —; 
 —(CH 2 ) o CH═CH(CH 2 ) n —; 
 —(CH 2 ) n O(CH 2 ) n —; 
 —(CH 2 ) n NR(CH 2 ) n —; 
 —(CH 2 ) o C≡C(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n CHY(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n CH═CH(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n O(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) b NR(CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n S(O) m (CH 2 ) n —; 
 —(CH 2 ) n C(O)O(CH 2 ) n C≡C(CH 2 ) n — or; 
 a 5- or 6-membered aromatic ring diradical optionally containing 1 or more heteroatoms independently selected from oxygen, nitrogen and sulfur, the 5- or 6-membered aromatic ring diradical optionally substituted by hydroxy, hydroxyalkyl, halogen, amino, alkyl, or alkoxyalkyl; 
 
       R is independently hydrogen, alkyl, cycloalkyl or aryl; 
       Y is a halogen; 
       n is independently 1-8; 
       m is 0, 1, or 2; and 
       o is 0-8. 
     
     
         7 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein W or W′ is enzymatically degradable in vivo. 
     
     
         8 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein said D or said arylsulfonamide is enzymatically cleaved in vivo from said chemical bond or linker. 
     
     
         9 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein said D or said arylsulfonamide is physiologically hydrolyzed in vivo from said chemical bond or linker. 
     
     
         10 . The therapeutic amine-arylsulfonamide conjugate of  claim 1 , wherein said therapeutic amine-arylsulfonamide conjugate is:
 (2S,3S,5R)-4-[5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxymethoxycarbonyl]-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol;   (2S,3S,5R)-4-[2-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)ethanoyloxymethoxycarbonyl]-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol;   (2S,3S,5R)-4-[2-(2-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)ethoxy)ethanoyloxymethoxycarbonyl]-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol;   (2S,3S)-4-[5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxymethoxycarbonyl]-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol;   (2S,3S)-4-[2-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)ethanoyloxymethoxycarbonyl]-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol;   2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethyl 4-(3-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)propoxy)(4-oxo)butanoate;   2-(1-(3-chlorobenzoyl)-(R,S)-ethylamino)-2,2-dimethylethyl 4-(3-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)propoxy)(4-oxo)butanoate;   2-[(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxymethoxycarbonyl)(1,1-dimethylethyl)amino]-1-(3-chlorophenyl)-1-propanone;   2-[(2-(5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoyloxy)ethanoyloxymethoxycarbonyl)(1,1-dimethylethyl)amino]-1-(3-chlorophenyl)-1-propanone;   2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethyl 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoate:   2-(1-(3-chlorobenzoyl)-(R,S)-ethylamino)-2,2-dimethylethyl 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoate; or   2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethyl 6-(5-carboxy-2-chloro-4-[(2-furanylmethyl)amino]phenylsulfonamidocarbonyloxymethoxy)(6-oxo)hexanoate.   
     
     
         11 . A method of making a therapeutic amine-sulfonamide conjugate compound according to  claim 1 , comprising:
 reacting a therapeutic amine radical, an arylsulfonamide radical, and optionally a linker; and   isolating a therapeutic amine-arylsulfonamide conjugate compound connected by a chemical bond or the linker, or a pharmaceutically acceptable salt or solvate of said therapeutic amine-arylsulfonamide conjugate compound.   
     
     
         12 . A method of ameliorating or attenuating a known or potential convulsant, pro-convulsant, or abuse liability condition, said condition resulting from administration of a therapeutic amine, comprising:
 administering to a patient in need thereof a therapeutically effective amount of an therapeutic amine-arylsulfonamide conjugate compound (I):   
       
         
           
           
               
               
           
         
         wherein 
         R′ is [D-W-], hydroxyl, or alkoxyl; 
         R″ is independently [D-W′-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur; 
         D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; 
         W and W′ are a chemical bond or linker; 
         wherein either R′ is [D-W-] or at least one R″ is [D-W′-], and pharmaceutically acceptable esters, amides, salts or solvates thereof. 
       
     
     
         13 . The method of  claim 12 , wherein the therapeutic amine radical is derived from amines selected from the group consisting of: manifaxine; 2-(1-(3,5-difluorobenzoyl)-(R,S)-ethylamino)-(R)-2-methylethanol; (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol; radafaxine; 2-(1-(3-chlorobenzoyl)-(R,S)-ethylamino)-2,2-dimethylethanol; bupropion; citalopram; escitalopram; paroxetine; fluoxetine; fluvoxamine; sertraline; phenelzine; tranylcypromine; amitriptyline; amoxapine; clomipramine; desipramine; doxepine; imipramine; nortryptyline; protriptyline; trimipramine; maprotiline; mirtazapine; duloxetine; nefazodone; trazodone; and venlafaxine. 
     
     
         14 . A method of treating one or more or a combination of one or more of a psychiatric, a neurologic and/or a metabolic disorder, the method comprising:
 administering to a patient in need thereof a therapeutically effective amount of a therapeutic amine-arylsulfonamide conjugate compound (I):   
       
         
           
           
               
               
           
         
         wherein 
         R′ is [D-W-], hydroxyl, or alkoxyl; 
         R″ is independently [D-W′-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur; 
         D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; 
         W and W′ are a chemical bond or linker; 
         wherein either R′ is ID-W-1 or at least one R″ is [D-W′-], 
         and pharmaceutically acceptable esters, amides, salts or solvates thereof. 
       
     
     
         15 . The method of  claim 14 , wherein the psychiatric, neurologic and/or metabolic disorder is depression, obesity, fibromyalgia, neuropathic pain, restless leg syndrome, attention deficit hyperactivity disorder (ADHD), migraine, pain, sexual dysfunction, Parkinson's disease, Alzheimer's disease, anxiety, narcolepsy-cataplexy syndrome, seizures, drug/substance addiction/cessation or combinations thereof.