US2010316582A1PendingUtilityA1

Visibly transparent uv photoprotective compositions

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Assignee: ANTARIA LTDPriority: Jan 11, 2008Filed: Jul 9, 2010Published: Dec 16, 2010
Est. expiryJan 11, 2028(~1.5 yrs left)· nominal 20-yr term from priority
Inventors:Takuya TsuzukiGeoffrey TrotterLauren ButlerPaul Mccormick
C01P 2006/14A61K 8/27C01P 2006/12C01P 2004/45C01P 2004/03Y10T428/2982C01P 2004/51A61Q 17/04C01P 2006/17C01P 2006/60A61K 2800/262C01G 9/02
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Claims

Abstract

A broad-spectrum UV photoprotective composition is described. The composition is characterized in that the composition comprises mesoporous zinc oxide aggregates having an average aggregate size of at least 0.8 microns dispersed in a carrier and the composition is visibly transparent. Sufficient zinc oxide is included in the composition to achieve an SPF greater than 15, greater than 25, greater than 30, or greater than 50.

Claims

exact text as granted — not AI-modified
1 . A broad-spectrum UV photoprotective composition characterized in that the composition comprises mesoporous zinc oxide aggregates having an average aggregate size of at least 0.8 micron dispersed in a carrier and the composition is visibly transparent. 
     
     
         2 . The composition according to  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least one of greater than 1.0 micron, greater than 2.0 microns and greater than 3.0 microns. 
     
     
         3 . The composition according to  claim 1  wherein the mesoporous zinc oxide aggregates are present in an amount effective to provide an SPF of at least one of greater than 15, greater than 25, greater than 30, and greater than 50. 
     
     
         4 . The composition of  claim 1  having a total absorptance through a path length of 20 microns at 550 nm not greater than 0.15 when the composition includes zinc oxide aggregates at a concentration of at least 40% or 50% by weight of the total composition. 
     
     
         5 . The composition of  claim 1  having a total absorptance through a path length of 20 microns at 550 nm not greater than 0.14 when the composition includes zinc oxide aggregates at a concentration of 30% by weight of the total composition. 
     
     
         6 . The composition of  claim 1  having a total absorptance through a path length of 20 microns at 550 nm not greater than 0.12 when the composition includes zinc oxide aggregates at a concentration of at least 20% by weight of the total composition. 
     
     
         7 . The composition of  claim 1  having a total absorptance through a path length of 20 microns at 550 nm not greater than 0.06 when the composition includes zinc oxide aggregates at a concentration of at least 10% by weight of the total composition. 
     
     
         8 . The composition of  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least 3.0 microns and the composition has a total absorptance at 550 nm through a path length of 20 microns not greater than 0.20. 
     
     
         9 . The composition of  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least 2.0 microns and the composition has a total absorptance at 550 nm through a path length of 20 microns not greater than 0.16. 
     
     
         10 . The composition of  claim 1  further comprising a dibenzoylmethane derivative. 
     
     
         11 . The composition of  claim 1  including less than 5% or less than 3% of an organic sunscreen filter. 
     
     
         12 . A photostable visibly-transparent, broad-spectrum UV photoprotective composition according to  claim 11  wherein the organic sunscreen filter is avobenzone. 
     
     
         13 . The composition of  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least one of greater than 1.0 micron, greater than 2.0 microns and greater than 3.0 microns and the composition has a soft focus factor at 550 nm greater than 40. 
     
     
         14 . The composition of  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least one of greater than 1.0 micron, greater than 2.0 microns and greater than 3.0 microns and the composition has a CIE Whiteness index less than 25. 
     
     
         15 . The composition  claim 1  wherein the zinc oxide aggregates have an average aggregate size of at least one of greater than 1.0 micron, greater than 2.0 microns or greater than 3.0 microns and the composition has a CIE L*lightness less than 30. 
     
     
         16 . The composition of  claim 1  including one or more non-mesoporous zinc oxide aggregate photoprotective agents, wherein the one or more non-mesoporous zinc oxide aggregate photoprotective agent(s) are present in a concentration that increases the SPF of the composition by not more than 2 units of SPF. 
     
     
         17 . A method of providing protection from ultraviolet radiation to mammalian skin or hair comprising contacting the skin or hair with a composition according to  claim 1 . 
     
     
         18 . A method of treating a human dermatologic condition selected from the group consisting of acne, psoriasis, eczema, ichthyosis, pruritus, dryness and dermatitis by applying a therapeutically-effective amount of a visibly-transparent topical preparation comprising the composition according to  claim 1 .

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