US2010317010A1PendingUtilityA1

ELF3 gene compositions and methods

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Individually held — no corporate assignee on recordPriority: Nov 22, 2002Filed: May 17, 2010Published: Dec 16, 2010
Est. expiryNov 22, 2022(expired)· nominal 20-yr term from priority
Inventors:Mark H. KaplanMichael H. DosikXue-Ping Wang
C12Q 1/701C12Q 2600/112C07K 14/4702C12Q 2600/158C07K 14/47C12Q 1/6886C12Q 2600/156
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Claims

Abstract

ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5′ untranslated region, and a novel Alu, Alu kwd . Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises a virus are also provided.

Claims

exact text as granted — not AI-modified
1 - 90 . (canceled) 
     
     
         91 . A method for determining whether a patient has cancer or is at risk for cancer, the method comprising evaluating whether a cell in the patient comprises a nucleic acid sequence selected from the group consisting of an ELF3 mRNA retaining at least a portion of an intron, a sequence at least 95% homologous to SEQ ID NO: 15, and an Alu kwd , wherein a patient comprising at least one of those sequences has cancer or is at risk for cancer. 
     
     
         92 . The method of  claim 91 , wherein the sequence is ELF3 mRNA retaining at least a portion of an intron. 
     
     
         93 . The method of  claim 91 , wherein the sequence is SEQ ID NO: 15. 
     
     
         94 . The method of  claim 91 , wherein the sequence is Alu kwd . 
     
     
         95 . The method of  claim 94 , wherein the sequence is SEQ ID NO: 15. 
     
     
         96 . The method of  claim 91 , the method further comprising a polymerase chain reaction. 
     
     
         97 . The method of  claim 96 , wherein the method comprises reverse transcriptase-polymerase chain reaction. 
     
     
         98 . The method of  claim 96 , wherein the polymerase chain reaction is a real time PCR. 
     
     
         99 . The method of  claim 91 , the method further comprising a northern hybridization or a Southern hybridization. 
     
     
         100 . The method of  claim 91 , the method further comprising sequencing the nucleic acid sequence. 
     
     
         101 . The method of  claim 91 , wherein the cell is a PBMC. 
     
     
         102 . The method of  claim 91 , wherein the cell is from a blood sample or a tissue biopsy. 
     
     
         103 . The method of  claim 102 , wherein the cell is from a tissue biopsy and the tissue is breast tissue. 
     
     
         104 . The method of  claim 103 , wherein the cell is from a tissue effusion. 
     
     
         105 - 118 . (canceled)

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