Solubilizing agents for active or functional organic compounds

Abstract

An active or functional organic compound is solubilized by an ester of an aryl alcohol, e.g., phenethyl, benzyl or substituted benzyl alcohol, and an alkyl or cycloalkyl carboxylic acid, or by a carbonate of said aryl alcohol and an alkyl or cycloalkyl carbonic acid.

1 . A composition of an active or functional organic compound solubilized in an ester of (i) an aryl alcohol and (ii) an alkyl or cycloalkyl carboxylic or carbonic acid wherein the ester has one of the following named formulas: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         2 . A composition according to  claim 1  in which said ester is 2-phenylethyl pentanoate. 
     
     
         3 . A composition according to  claim 1  in which said ester is 2-phenylethyl cyclohexanoate. 
     
     
         4 . A composition according to  claim 1  in which said active compound is a solid organic compound. 
     
     
         5 . A composition according to  claim 1  wherein said active or functional compound is a personal care, cosmetic, or pharmaceutical compound. 
     
     
         6 . A composition according to  claim 1  which is a sunscreen composition. 
     
     
         7 . A sunscreen composition according to  claim 6  in which said active compound is solubilized in an amount of at least 10 wt. %. 
     
     
         8 . A sunscreen composition according to  claim 6  in which said active is avobenzone, oxybenzone, 4-methylbenzylidene camphor, ethylhexyl triazone or bis-ethylhexyloxyphenol methoxyphenyl triazine, or mixtures thereof. 
     
     
         9 . A sunscreen composition according to  claim 7  in which said active is avobenzone, oxybenzone, 4-methylbenzylidene camphor, ethylhexyl triazone or bis-ethylhexyloxyphenol methoxyphenyl triazine, or mixtures thereof. 
     
     
         10 . A sunscreen composition according to  claim 6  in which said active is selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5,4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof. 
     
     
         11 . A sunscreen composition according to  claim 7  in which said active is selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5,4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor; ethylhexyl salicylate; ethylhexyl-dimethyl PABA; methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof. 
     
     
         12 . A composition according to  claim 1  wherein said active or functional organic compound is selected from the group consisting of agricultural and industrial compounds. 
     
     
         13 . A composition according to  claim 1  wherein said active or functional organic compound is selected from the group consisting of furosemide, lovastatin, clarithromycin, diclofenac, famotidine, carbamaxepine, dipyridamole, chlorthiazide, spironolactone, dilantin, imipranine, mefloquine, cyclosporine, glyburide, nimodipine, and mixtures thereof. 
     
     
         14 . A composition according to  claim 1  comprising a UV filter compound and a pharmaceutical compound. 
     
     
         15 . A composition according to  claim 1  comprising at least two active or functional organic compounds selected from the group consisting of UV filter, cosmetic, and pharmaceutical compounds. 
     
     
         16 . A composition according to  claim 14  comprising a UV filter compound selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5,4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof, and a pharmaceutical compound selected from the group consisting of furosemide, lovastatin, clarithromycin, diclofenac, famotidine, carbamaxepine, dipyridamole, chlorthiazide, spironolactone, dilantin, imipranine, mefloquine, cyclosporine, glyburide, nimodipine, and mixtures thereof. 
     
     
         17 . A composition comprising an active or functional organic compound solubilized in an ester of (i) a phenylethyl alcohol and (ii) an alkyl or cycloalkyl carboxylic or carbonic acid. 
     
     
         18 . A composition according to  claim 17  wherein said composition is a sunscreen composition and said active is selected from the group consisting of avobenzone, benzophenone-3, benzophenone-4, benzophenone-5,4-methylbenzylidene camphor, p-aminobenzoic acid (PABA), camphor benzalkonium methosulfate, homosalate, phenylbenzimidazole sulfonic acid, terephthalidene dicamphor sulfonic acid, benzylidene camphor sulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 PABA, isoamyl p-methoxycinnamate, ethylhexyl triazone, drometrizole trisiloxane, diethylhexyl butamido triazone, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, methylene bis-benztriazolyl tetramethylbutylphenol, disodium phenyl dibenzimidazole tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15, and mixtures thereof. 
     
     
         19 . A composition according to  claim 17  in which said ester is the ester of 2-phenylethyl alcohol.