Use of chemotherapeutic agents

Abstract

The use of chemotherapeutic agents for the preparation of a medicament for the topical and/or local treatment of diseases caused by bacteria and/or for prophylaxis in humans or animals.

1 . A method for the treatment of endodontal diseases in a subject in need thereof, said method comprising topically and/or locally administering to said subject a therapeutically effective amount of a medicament selected from the group consisting of moxifloxacin and/or its corresponding hydrate, and/or its corresponding physiologically compatible acid addition salt, and/or optionally the corresponding physiologically compatible salt of the carboxylic acid on which it is based, and/or corresponding enantiomers, and/or corresponding diastereomers, and/or corresponding racemates, and optionally other physiologically compatible auxiliary substances. 
     
     
         2 . The method according to  claim 1 , wherein the moxifloxacin is in the form of an acid addition salt selected from the group consisting of hydrochloride, hydrobromide, methanesulfonate and tolylsulfonate salts. 
     
     
         3 . The method according to  claim 1 , wherein the moxifloxacin is in the form of a physiologically compatible salt of the carboxylic acid selected from the group consisting of alkali metal salts, alkaline earth metal salts, ammonium salts, silver salts and guanidinium salts. 
     
     
         4 . The method according to  claim 1  for the local treatment of pulpitis due to carious diseases, for the prophylaxis of dentin wounds, or for the topical treatment of infected root canal and/or periapical region. 
     
     
         5 . The method according to,  claim 1  wherein the medicament is in the form of a gel, a solution, a suspension, an emulsion, liposomes or micelles, and has optionally been applied to or incorporated in a carrier material or an inert carrier. 
     
     
         6 . The method according to  claim 5 , wherein the medicament is in the form of an aqueous solution. 
     
     
         7 . The method according to  claim 5 , wherein the medicament contains, as other physiologically compatible auxiliary substances, solvents, thickeners, solubilizers, preservatives, emulsifiers, mucins, osmolality regulators, antioxidants, chelating agents, disinfectants, dispersants, emulsion stabilizers, hydrocolloids, wetting agents or a mixture of at least two of the abovementioned auxiliary substances. 
     
     
         8 . The method according to  claim 5  wherein the medicament is in the form of a strip insert, thread insert, chip, tray, collagen sponge, tampon, cotton wool plug, or foam pellet. 
     
     
         9 . The method according to  claim 1 , wherein the medicament is present in the form of a gel or a solution in a concentration of 0.005 mg/ml to 200 mg/ml. 
     
     
         10 . The method according to  claim 1 , wherein the subject is selected from humans and animals. 
     
     
         11 . The method according to  claim 1 , wherein the moxifloxacin is moxifloxacin HCl.