US2010331235A1PendingUtilityA1

Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseases

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Assignee: UNIV MANCHESTERPriority: Feb 20, 2008Filed: Feb 18, 2009Published: Dec 30, 2010
Est. expiryFeb 20, 2028(~1.5 yrs left)· nominal 20-yr term from priority
Inventors:Neil Kerslake Gibbs
A61P 37/08A61P 17/14A61P 17/04A61K 31/4172A61P 17/06A61P 17/10A61P 17/00A61P 17/02
45
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Claims

Abstract

Histidine and/or a derivative thereof. In some embodiments, the histidine and/or a derivative thereof is used in maintaining and/or improving barrier function of the skin of a subject. In some embodiments, the histidine and/or a derivative thereof is used for the prevention and/or treatment of an inflammatory skin disease.

Claims

exact text as granted — not AI-modified
1 . Histidine and/or a derivative thereof for use in maintaining and/or improving barrier function of the skin of a subject. 
     
     
         2 . Histidine and/or a derivative thereof for use in the prevention and/or treatment of an inflammatory skin disease of a subject. 
     
     
         3 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the inflammatory skin disease is selected from one or more of atopic dermatitis, psoriasis, acne, ichthyosis, contact dermatitis, eczema, photodermatoses and dry skin disorders. 
     
     
         4 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the inflammatory skin disease is atopic dermatitis. 
     
     
         5 . Histidine and/or a derivative thereof for use in combination with phototherapy. 
     
     
         6 . Histidine and/or a derivative thereof for use according to  claim 1 , wherein the histidine and/or the derivative thereof is for use in combination with phototherapy. 
     
     
         7 . Histidine and/or a derivative thereof for use according to  claim 1 , wherein the histidine and/or the derivative thereof is formulated as a pharmaceutical composition. 
     
     
         8 . Histidine and/or a derivative thereof for use according to  claim 1 , wherein the histidine and/or the derivative thereof is formulated as a nutritional product. 
     
     
         9 . Histidine and/or a derivative thereof for use according to  claim 1 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         10 . Histidine (preferably L-histidine) for use according to  claim 1 . 
     
     
         11 . A pharmaceutical composition comprising a therapeutically effective amount of histidine and/or a derivative thereof as the active ingredient in combination with a pharmaceutically-acceptable diluent or carrier, wherein the histidine and/or the derivative thereof is the only active ingredient in the pharmaceutical composition. 
     
     
         12 . A pharmaceutical composition comprising a therapeutically effective amount of histidine and/or a derivative thereof as the active ingredient in combination with a pharmaceutically-acceptable diluent or carrier, wherein the pharmaceutical composition is formulated for oral administration. 
     
     
         13 . The pharmaceutical composition according to  claim 11 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         14 . The pharmaceutical composition according to  claim 11 , wherein the active ingredient is histidine, preferably L-histidine. 
     
     
         15 . (canceled) 
     
     
         16 . A nutritional product comprising a therapeutically effective amount of histidine and/or a derivative thereof as the active ingredient, wherein the histidine and/or the derivative thereof is the only active ingredient in the nutritional product. 
     
     
         17 . The nutritional product according to  claim 16 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         18 . The nutritional product according to  claim 16 , wherein the active ingredient is histidine, preferably L-histidine. 
     
     
         19 . (canceled) 
     
     
         20 . (canceled) 
     
     
         21 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the histidine and/or the derivative thereof is for use in combination with phototherapy. 
     
     
         22 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the histidine and/or the derivative thereof is formulated as a pharmaceutical composition. 
     
     
         23 . Histidine and/or a derivative thereof for use according to  claim 5 , wherein the histidine and/or the derivative thereof is formulated as a pharmaceutical composition. 
     
     
         24 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the histidine and/or the derivative thereof is formulated as a nutritional product. 
     
     
         25 . Histidine and/or a derivative thereof for use according to  claim 5 , wherein the histidine and/or the derivative thereof is formulated as a nutritional product. 
     
     
         26 . Histidine and/or a derivative thereof for use according to  claim 2 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         27 . Histidine and/or a derivative thereof for use according to  claim 5 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         28 . Histidine (preferably L-histidine) for use according to  claim 2 . 
     
     
         29 . Histidine (preferably L-histidine) for use according to  claim 5 . 
     
     
         30 . The pharmaceutical composition according to  claim 12 , wherein the derivative is selected from one or more of a peptide of histidine, a peptide of histidine and one or more additional amino acids, and a pharmaceutically-acceptable salt of histidine. 
     
     
         31 . The pharmaceutical composition according to  claim 12 , wherein the active ingredient is histidine, preferably L-histidine. 
     
     
         32 . The nutritional product according to  claim 17 , wherein the active ingredient is histidine, preferably L-histidine.

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