Antimicrobial and antiinflammatory composition

Abstract

The invention relates to the use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition as well as a method of producing said composition.

1 . A method of treating a microbial and/or inflammatory disease in a subject in need thereof, comprising:
 administering to the subject a composition comprising:
 0.0025 to 1.0% (w/v) of a combination of davanone and 1,8 cineol; 
 0.1 to 100 μg/ml casticin; 
 0.1 to 100 μg/ml centaureidin; 
 0.1 to 100 μg/ml quercetin 3,4-dimethyl ether; and 
 0.1 to 100 μg/ml quercetin 3,7-dimethyl ether. 
   
     
     
         2 . The method of  claim 1 , wherein the disease is herpes simplex infection, tinea pedis, impetigo, dandruff, or pityriasis versicolor infection. 
     
     
         3 . The method of  claim 1 , wherein the composition is in the form of a gel, spray, shampoo, or cream. 
     
     
         4 . The method of  claim 3 , wherein the composition is in the form of a gel or a cream. 
     
     
         5 . The method of  claim 1 , wherein the davanone is from  A. pallens , the 1,8-cineol is from  Eucalyptus globulus , and the flavonols are from  A. abrotanum.    
     
     
         6 . The method of  claim 5 , wherein the davanone, 1,8-cineol and flavonols are from  A. abrotanum.    
     
     
         7 . The method of  claim 1 , wherein the davanone, 1,8-cineola, and flavonols are from one or more plants selected from the group consisting of  A. oelandicum, A. dracunculus, A. campestris, A. vulgaris, A. absinthium, A. stelleriana, A. rupestris, A. abrotanum, A. pallens, A. lerchiana, A. thuscula, A. rehan, A. persica, A. glabella, Lantana camara  and  Tanacetum vulgare.    
     
     
         8 . The method of  claim 7 , wherein the disease is herpes simplex infection, tinea pedis, impetigo, dandruff, or pityriasis versicolor infection. 
     
     
         9 . The method of  claim 7 , wherein the composition is in the form of a gel, spray, shampoo, or cream. 
     
     
         10 . The method of  claim 9 , wherein the composition is in the form of a gel or a cream. 
     
     
         11 . The method of  claim 7 , wherein the davanone is from  A. pallens , the 1,8-cineol is from  Eucalyptus globulus , and the flavonols are from  A. abrotanum.    
     
     
         12 . The method of  claim 7 , wherein the davanone, 1,8-cineol and flavonols are from  A. abrotanum.