Novel compounds useful for modulating abnormal cell proliferation

Abstract

There is described compounds of Formulæ I, II, III, IV and V. The compounds of Formulæ I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

1 - 7 . (canceled) 
     
     
         8 . A compound of Formula III, and salts, solvates and hydrates thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1  is selected from OH, OC 1-6 alkyl, NO 2 ; 
 R 2  is selected from H, OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6 alkyl, C(O)OC 1-6 alkyl, NH 2 , NH—C 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), C(O)NHC 1-6 alkyl, C(O)N(C 1-6 alkyl)(C 1-6 alkyl), SH, SC 1-6 alkyl, NO 2 ; CF 3 , OCF 3  and halo; 
 R 3  is selected from C(X) R 4 , SO 2 Ar, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), P(O)(OH) 2 , P(O)(OC 1-6 alkyl) 2 , and C(NH 2 )═C(CN) 2 ; 
 R 4  is selected from NH 2 , OH, OC 1-6 alkyl, OAr, NHAr, NH(CH 2 ) n Ar, NH(CH 2 )—OH, (CH 2 ) n OC 1-6 alkyl, C 1-6 alkyl, NHNH 2 , NHC(O)NH 2 , NHC(O)C 1-6 alkoxy, N-morpholino and N-pyrrolidino; 
 Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents independently selected from OH, C 1-6 allyl, C 1-6 alkoxy, C 1-3 alkylenedioxy, NH 2 , NH—C 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), SH, NO 2 , CF 3 , OCF 3  and halo; 
 X is selected from O and S; 
 Y is selected from (CH 2 CH 2 O) p ; 
 n is 1 to 6; and 
 p is 1 to 3. 
 
     
     
         9 . (canceled) 
     
     
         10 . (canceled) 
     
     
         11 . (canceled) 
     
     
         12 . A compound of Formula IV, and salts, solvates and hydrates thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 A is a ring chosen from benzene, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH C 1-6 alkyl, C 1-6 alkoxy, C 1-3 alkylenedioxy, NH 2 , NH—C 1-6  alkyl, N(C 1-6 alkYl)(C 1-6 alkyl), SH, S—C 1-6 alkyl, NO 2 , CF 3 , OCF 3  and halo; 
 B is a ring chosen from benzene and pyridine; 
 R 1  is selected from C(X) R 2 , SO 2 Ar, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), P(O)(OH) 2 , P(O)(OC 1-6 alkyl) 2 , and C(NH 2 )═C(CN) 2 ; 
 R 2  is selected from NH 2 , OH, OC 1-6 alkyl, OAr, OYC 1-3 alkyl, NHAr, NH(CH 2 ) n Ar, NH(CH 2 ) n OH, (CH 2 )—OC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy, NHNH 2 , NHC(O)NH 2 , NHC(O)C 1-6 alkoxy, N-morpholino and N-pyrrolidino; 
 Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents independently selected from OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-3 alkylenedioxy, NH 2 , NH—C 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), SH, S—C 1-6 alkyl, NO 2 , CF 3 , OCF 3  and halo; 
 X is selected from O and S; 
 Y is selected from (CH 2 CH 2 O) p ; 
 n is 1 to 6; and 
 p is 1 to 3. 
 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . (canceled) 
     
     
         16 . A compound of Formula V, and salts, solvates and hydrates thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1 , R 2  and R 3  are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6 alkyl, C(O)OC 1-6 alkyl, NH 2 , N(C 1-6 alkyl)(C 1-6 alkyl), C(O)NHC 1-6 alkyl, C(O)N(C 1-6 alkyl)(C 1-6 alkyl), SH, SC 1-6 alkyl, NO 2 , CF 3 , OCF 3  and halo; 
 R 4  is selected from C(X) R 5 , SO 2 Ar, NH 2 , NHC 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), P(O)(OH) 2 , P(O)(OC 1-6 alkyl) 2 , and C(NH 2 )═C(CN) 2 ; 
 R 5  is selected from NH 2 , OH, OC 1-6 alkyl, OAr, OYC 1-3 alkyl, NHAr, NH(CH 2 ) n Ar, NH(CH 2 ) n OH, (CH 2 ) n OC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkoxy, NHNH 2 , NHC(O)NH 2 , NHC(O)C 1-6 alkoxy, N-morpholino and N-pyrrolidino; 
 Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents independently selected from OH, C 1-6 alkyl, C 1-6 alkoxy, C 1-3 alkylenedioxy, NH 2 , NH—C 1-6 alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), SH, S—C 1-6 alkyl, NO 2 , CF 3 , OCF 3  and halo; 
 X is selected from O and S; 
 Y is selected from (CH 2 CH 2 O) p ; 
 n is 1 to 6; and 
 p is 1 to 3. 
 
     
     
         17 - 38 . (canceled)