Method for Preparation of Extract from Angelica Gigas Nakai and Composition Containing the Extract

Abstract

Disclosed is Angelica gigas Nakai extract powder prepared by a process including: (a) preparing 85-100% (v/v) pure ethanol and adjusting a pH value of the ethanol to pH 7-9 with an alkaline solution; (b) adding 3-10× of the prepared ethanol to the total weight of Angelica gigas Nakai herb, which is naturally grown or harvested; (c) conducting extraction of the same at 30-75° C. for 3-8 hrs; (d) measuring a pH value of the treated mixture at 15 m intervals and adjusting the same to pH 7-9 with the alkaline solution during the extraction, while stopping the pH control at 1 hr prior to completion of the extraction; (e) filtering and concentrating the obtained extract to 3× the net weight of Angelica gigas Nakai; (f) cooling and settling the treated mixture at 10-30° C. for 1-24 hrs to remove a settled precipitate; (g) adding an excipient such as microcrystalline cellulose, dextrin, etc. to a concentrate remaining after removal of the precipitate; and (g) drying and pulverizing the resulting product.

1 . A composition including  Angelica gigas  Nakai extract wherein decursin, decursinol angelate and decursinol are contained in relative ratios of 50 to 200:1 in terms of (decursin+decursinol angelate) to decursinol. 
     
     
         2 . A method for the preparation of  Angelica gigas  Nakai extract as set forth in  claim 1 , including: preparing 85 to 100% (v/v) ethanol as solvents and adjusting the pH value of the ethanol to pH 7 to 9 with an alkaline solution; adding 3 to 10 times of the prepared ethanol to the total weight of  Angelica gigas  Nakai herb in a dried state; elevating a temperature of the mixture and conducting extraction of the same for 3 to 8 hours; measuring a pH value of the treated mixture at 15 minute intervals and adjusting the same to pH 7 to 9 with the alkaline solution during the extraction; concentrating the obtained extract and cooling to remove a precipitates; adding an excipient to the concentrate remaining after removal of the precipitates; and drying and pulverizing the resulting product. 
     
     
         3 . A composition with analgesic efficacies, including the composition as set forth in  claim 1  as a main component. 
     
     
         4 . A composition with antioxidant effects, including the composition as set forth in  claim 1  as a main component. 
     
     
         5 . The method according to  claim 2 , wherein the alkaline solution comprises at least one selected from a group consisting of sodium hydroxide, potassium hydroxide, magnesium hydroxide and calcium hydroxide.