Use of Creatine or Creatine Compounds for Skin Preservation

Abstract

The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

1 . A composition for the treatment of the skin of a subject, comprising an effective amount of creatine, creatine phosphate, a creatine compound or a salt thereof, a pharmaceutically acceptable carrier suitable for topical administration, and a sunscreen or a sunblock. 
     
     
         2 . The composition of  claim 1 , wherein said sunscreen or sunblock is effective to against UVA, UVB, or UVA and UVB. 
     
     
         3 . The composition of  claim 1 , wherein said sunscreen or sunblock is zinc oxide or titanium dioxide. 
     
     
         4 . The composition of  claim 1 , wherein said suncreening agent is p-aminobenzoic acid, anthranilate, salicylate. a cinnamic acid derivative, α-phenyl cinnamonitrile; butyl cinnamoyl pyruvate, dihydroxycinnamic acid derivative, umbelliferone, methylumbelliferone, methylaceto-umbelliferone, trihydroxycinnamic acid derivative, esculetin, methylesculetin, daphnetin, esculin, daphnin, a hydrocarbon, diphenylbutadiene, stilbene, dibenzalacetone, benzalacetophenone, naphtholsulfonates, 2-naphthol-3,6-disulfonic acid, 2-naphthol-6,8-disulfonic acid, dihydroxy-naphthoic acid, o- or p-hydroxybiphenyldisulfonate, coumarin derivative, 7-hydroxy, 7-diazole, 2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthoxazole, aryl benzothiazole, quinine, quinoline derivative, 8-hydroxyquinoline salts, 2-phenylquinoline, hydroxy- or methoxy-substituted benzophenones, uric acid, vilouric acid, tannic acid or derivatives thereof, hexaethylether, butyl carbotol, 6-propyl piperonyl ether, hydroquinone, benzophenone, oxybenzene, sulisobenzone, dioxybenzone, benzoresorcinol, 2,2′,4,4′-tetrahydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, octabenzone; 4-iso-propyldibenzoylmethane, butylmethoxydibenzoylmethane; etocrylene, 4-isopropyl-di-benzoylmethane, or derivatives or mixtures thereof. 
     
     
         5 . The composition of  claim 1 , wherein said suncreen or sunblock is 2-ethylhexyl-p-methoxycinnamate, butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl-p-aminobenzoic acid or mixtures thereof. 
     
     
         6 . The composition of  claim 1 , wherein said sunscreen or sunblock comprises an anti-inflammatory agent. 
     
     
         7 . The composition of  claim 1 , wherein said composition further comprises an effective amount of a skin protectant. 
     
     
         8 . The composition of  claim 7 , wherein said skin protectant is allantoin, aluminum hydroxide gel, bismuth subnitrate, boric acid, calamine, cocoa butter, corn starch, dimethicone, glycerin, kaolin, live yeast cell derivative, petrolatum, shark liver oil, sodium bicarbonate, sulfur, tannic acid, white petrolatum, zinc acetate, zinc carbonate or zinc oxide or mixtures thereof. 
     
     
         9 . The composition of  claims 1 , wherein said effective amount is effective to treat for skin damage resulting from sun radiation. 
     
     
         10 . The composition of  claim 1 , wherein said creatine compound is creatine, creatine citrate, creatine ascorbate, cyclocreatine, or creatine phosphate. 
     
     
         11 . The composition of  claim 1 , wherein said pharmaceutically acceptable carrier is suitable for administration as a lotion, cream, mousse, aerosol, gel, emulsion, solution, ointment, or medicated pad. 
     
     
         12 . A method for protecting the skin from damage resulting from sun radiation, comprising administering to a subject an effective amount of a creatine compound, such the skin is protected from sun radiation. 
     
     
         13 . The method of  claim 12 , further comprising administering a sunscreen or sunblock. 
     
     
         14 . The method of  claim 13 , wherein said sunscreen or sunblock is effective to against UVA, UVB, or UVA and UVB. 
     
     
         15 . The method of  claim 13 , wherein said sunscreen or sunblock is zinc oxide or titanium dioxide. 
     
     
         16 . The method of  claim 13 , wherein said suncreening agent is p-aminobenzoic acid, anthranilate, salicylate. a cinnamic acid derivative, α-phenyl cinnamonitrile; butyl cinnamoyl pyruvate, dihydroxycinnamic acid derivative, umbelliferone, methylumbelliferone, methylaceto-umbelliferone, trihydroxycinnamic acid derivative, esculetin, methylesculetin, daphnetin, esculin, daphnin, a hydrocarbon, diphenylbutadiene, stilbene, dibenzalacetone, benzalacetophenone, naphtholsulfonates, 2-naphthol-3,6-disulfonic acid, 2-naphthol-6,8-disulfonic acid, dihydroxy-naphthoic acid, o- or p-hydroxybiphenyldisulfonate, coumarin derivative, 7-hydroxy, 7-diazole, 2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthoxazole, aryl benzothiazole, quinine, quinoline derivative, 8-hydroxyquinoline salts, 2-phenylquinoline, hydroxy- or methoxy-substituted benzophenones, uric acid, vilouric acid, tannic acid or derivatives thereof, hexaethylether, butyl carbotol, 6-propyl piperonyl ether, hydroquinone, benzophenone, oxybenzene, sulisobenzone, dioxybenzone, benzoresorcinol, 2,2′,4,4′-tetrahydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, octabenzone; 4-iso-propyldibenzoylmethane, butylmethoxydibenzoylmethane; etocrylene, 4-isopropyl-di-benzoylmethane, or derivatives or mixtures thereof. 
     
     
         17 . The method of  claim 13 , wherein said suncreen or sunblock is 2-ethylhexyl-p-methoxycinnamate, butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl-p-aminobenzoic acid or mixtures thereof. 
     
     
         18 . The method of  claim 12 , further comprising administering an anti-inflammatory agent. 
     
     
         19 . The method of  claim 12 , wherein said composition further comprises an effective amount of a skin protectant. 
     
     
         20 . The method of  claim 19 , wherein said skin protectant is allantoin, aluminum hydroxide gel, bismuth subnitrate, boric acid, calamine, cocoa butter, corn starch, dimethicone, glycerin, kaolin, live yeast cell derivative, petrolatum, shark liver oil, sodium bicarbonate, sulfur, tannic acid, white petrolatum, zinc acetate, zinc carbonate or zinc oxide or mixtures thereof. 
     
     
         21 . The method of  claim 12 , wherein said subject is a human. 
     
     
         22 . The method of  claim 12 , wherein said creatine compound is creatine, creatine citrate, creatine ascorbate, cyclocreatine, or creatine phosphate.