US2011009589A1PendingUtilityA1
Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
Assignee: NEKTAR THERAPEUTICS AL CORPPriority: Jan 7, 1998Filed: Aug 20, 2010Published: Jan 13, 2011
Est. expiryJan 7, 2018(expired)· nominal 20-yr term from priority
C08G 65/3322Y10S530/81Y10S530/816C08G 65/329C08L 71/02C08L 2203/02A61K 47/60
60
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Claims
Abstract
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.
Claims
exact text as granted — not AI-modified1 . A compound selected from the group consisting of
CH 2 ═CHCO 2 —CH 2 CH 2 —O—(CH 2 CH 2 —O) n —CH 2 CH 2 —O—CH 2 CO 2 CH(CH 3 )CH 2 CONH—CH 2 CH 2 —O—(CH 2 CH 2 —O) n —CH 2 CH 2 —O 2 CCH═CH 2
and CH 2 ═CHCO 2 —CH 2 CH 2 —O—(CH 2 CH 2 —O) n —CH 2 CH 2 —O—CH 2 CO 2 —CH 2 CH 2 —O—(CH 2 CH 2 —O) n —CH 2 CH 2 —O 2 CCH═CH 2 ,
wherein n is an integer from about 10 to about 2000.Join the waitlist — get patent alerts
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