Preparations for tissue restoration containing atrial diuretic hormone and family molecules as active ingredients; method of restoring tissue using the preparation; agents for growing, restoring, promoting growth of hair and agents for promoting restoration of skin tissue and cardiac muscle tissue containing atrial diuretic hormone family molecules as active ingredients; method of growing, restoring, promoting growth of hair by using the agents; and method of promoting restoration of skin tissue and cardiac muscle tissue

Abstract

[Summary] [Object] To develop a preparation and a treatment method effective for improving a state of a bald hear, promoting hair growth, and restoring injuredskin tissues, supporting tissues, and cardiac muscle. [Solution] A preparation containing atrial diuretic hormone family molecules are used for restoration and regeneration of a tissue and an organ. The preparation is used for growing hairs and/or for improving and restoring failures of skin, mucosa, and subcutaneous tissue such as bed bore, rough and dry skin, burn injuries, necrosis, and psoriasis, and also for improving cardiac muscle failures.

1 . An agent for restoring and regenerating tissues and organs containing a composition comprising active ingredients such as atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), C-type diuretic hormone (CNP), urodilatin phosphate (P-Uro) and precursors and derivatives thereof, or a combination there and one or more auxiliary agents such as a diluent, an excipient, or a filler. 
     
     
         2 . A method of the agent according to  claim 1  for restoring and regenerating a biological tissue or organ. 
     
     
         3 . The method according to  claim 2 , wherein the composition is administered by the systemic route, by systemic administration together with a protective drug, local application, cutaneous or subcutaneous injection, in a form of aerosol, intravenous injection, intravenous volus injection, or inhalation. 
     
     
         4 . The method according to  claim 3 , wherein the composition containing any of the ingredients, or a combination thereof, is administered by a dose rate of 1 mg to 100 μg/1 Kg of a body weight in one administration. 
     
     
         5 . The method according to  claim 4 , wherein the composition containing any of the ingredients, or a combination thereof, is administered at a dose of 10 ng to 10 μg for one local site to be treated. 
     
     
         6 . A method of producing a medicinal composition and a preparation for restoring and regenerating a tissue or an organ containing any of the active ingredients described in  claim 1  or a combination thereof and also containing an auxiliary agent such as a diluent, an excipient, or a filler if necessary. 
     
     
         7 . The method of  claim 6  of preparing a preparation which can be administered via skin or mucosa, by systemic administration via subcutaneous tissue, or inhalation. 
     
     
         8 . The method according to  claim 6 , wherein a medical agent containing any of the active ingredients, or a combination thereof, is administered by 1 ng to 100 μg per 1 Kg of a body weight is administered by a unit dose. 
     
     
         9 . The method according to  claim 8 , wherein a medical agent containing any of the active ingredients, or a combination thereof, is administered by 10 ng to 10 μg per 1 Kg of a body weight is administered by a unit dose. 
     
     
         10 . A treatment method with a preparation for restoring and regenerating a tissue or an organ and/or a preparation for restoring and medically treating a tissue or an organ, wherein the medical agent containing any of the active ingredients described in  claim 1  or a combination thereof and also containing an auxiliary agent such as a diluent, an excipient, or a filler if required is administered. 
     
     
         11 . The method according to  claim 9  for treating tissue failures of a living body. 
     
     
         12 . The method according to  claim 10 , wherein the composition is administered by the systemic route to a local site of a living body. 
     
     
         13 . The method according to  claim 9 , wherein the composition containing any of the active ingredients, or a combination thereof, is administered by 5 ng to 100 μg per 1 Kg of a body weight. 
     
     
         14 . The preparation for restoring or regenerating a tissue or an organ according to  claim 1 , wherein the preparation further contains a cell proliferating factor and a tissue restoring factor other than the ANP family molecules and/or cell tissue growth promoting factor. 
     
     
         15 . A preparation for restoring or regenerating a tissue of a living body according to  claim 1 , wherein the preparation further contains a neutral endopeptidase inhibitor, an anti-atrial diuretic hormone family molecule antibody, or an agent for modifying actions of the atrial diuretic hormone. 
     
     
         16 . A preparation for restoring and regenerating a tissue or an organ comprising a composition containing a gene and a vector each containing a nucleotide sequence capable of expressing the atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof as active ingredient and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         17 . A preparation for growing and restoring hairs and/or a preparation for improving and restoring failures of skin, mucosa, and subcutaneous tissues such as bed bore, rough and dry skin, a burn injury, the preparation containing atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof as active ingredient and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         18 . An application of the preparations according to  claim 17  to restoration of hairs, skin, mucosa, and a subcutaneous tissue. 
     
     
         19 . The method according to  claim 17 , wherein the composition is administered by the systemic route, by systemic administration together with a protective drug, local application, cutaneous or subcutaneous injection, in a form of aerosol, intravenous injection, intravenous volus injection, or inhalation. 
     
     
         20 . The method of using the composition containing any of the active ingredients described in  claim 17 , or a combination thereof, wherein the composition is administered by 1 ng to 100 μg per 1 Kg of a body weight in one administration. 
     
     
         21 . The method according to  claim 20 , wherein the composition containing any of the active ingredients, or a combination thereof, is administered by 1 ng to 100 μg in one administration to one local site to be treated. 
     
     
         22 . The method of producing a preparation for growing and restoring hairs and/or a preparation for treating failures of skin, mucosa, or a subcutaneous tissue by using the composition containing any of the active ingredients described in  claim 17  or a combination thereof and also containing an auxiliary agent such as a diluent, an excipient, or a filler if required. 
     
     
         23 . The method according to  claim 21 , wherein the method is applied to preparation of a medicinal agent capable of being administered by systemic administration via skin or mucosa, or by inhalation. 
     
     
         24 . The method according to  claim 21 , wherein a medicinal agent containing any of the active ingredients, or a combination thereof, by 1 ng to 100 μg per 1 Kg of a body weight is administered at a unit dose. 
     
     
         25 . The method according to  claim 24 , wherein a medicinal agent containing any of the active ingredients, or a combination thereof, by 10 ng to 10 μg per 1 Kg of a body weight is administered at a unit dose. 
     
     
         26 . A treatment method with a preparation for growing or restoring hairs and/or a preparation for treating failures of skin or mucosa, wherein a medicinal composition containing any of the active ingredients described in  claim 17  or a combination thereof and also containing a pharmacologically acceptable auxiliary agent such as a diluent, an excipient, or a filler if required is administered. 
     
     
         27 . The method according to  claim 26 , wherein the method is applied to treatment of failures of skin or mucosa. 
     
     
         28 . The method according to  claim 25 , wherein the composition is administered to a venous route by systemic administration or inhalation. 
     
     
         29 . The method according to  claim 26 , wherein the composition containing any of the active ingredients, or a combination thereof, is administered by 5 ng to 1000 μg per 1 Kg of a body weight in one administration. 
     
     
         30 . The preparation for promoting hair growth or, for improving and restoring skin and subcutaneous tissue according to  claim 17 , wherein the preparation contains other proliferating factor and/or a hair growth promoting agent. 
     
     
         31 . The preparation for promoting hair growth or for improving and restoring skin and subcutaneous tissue according to  claim 17 , wherein the preparation further contains a neutral endopeptidase inhibitor, an anti-atrial diuretic hormone family molecule antibody, or an agent for modifying actions of the atrial diuretic hormone. 
     
     
         32 . A preparation for restoring or regenerating a tissue or an organ containing a composition containing, as active ingredients, genes encoding atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof, and also containing an auxiliary agent such as a diluent, an excipient, or a filler if required. 
     
     
         33 . A preparation for growing and restoring hairs and/or a preparation for improving and restoring failures of skin, mucosa, and subcutaneous tissues such as bed bore, rough and dry skin, a burn injury, the preparation containing atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof as active ingredient and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         34 . A method of administering a preparation for restoring or regenerating a tissue or an organ to a local site during or after surgery, the preparation containing a composition containing atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof as active ingredient and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         35 . Cosmetics containing, as active ingredients, atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof. 
     
     
         36 . A method of administering, for curing ulcerous lesions, a composition containing atrial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof as active ingredient and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         37 . An additive for cell culturing containing, as active ingredients, trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof, and a method of culturing cells with the additive. 
     
     
         38 . A method of administering a preparation comprising a composition containing trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof, and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required intermittently and also continuously for 4 months or more at a frequency of once for each three days or less and also of once for every two weeks or more. 
     
     
         39 . A preparation for treatment of dilated cardiomyopathy comprising a composition containing trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof, and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         40 . A method of administering, intermittently and continuously, the reparation for treatment of dilated cardiomyopathy comprising a composition containing trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof or a combination thereof, and also containing pharmacologically acceptable auxiliary agents such as a diluent, an excipient, and a filler if required. 
     
     
         41 . A method of systemically administering the reparation for treatment of dilated cardiomyopathy containing trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof at the frequency of once or more for every two weeks ad once or less a day and also at a dose in the range from 0.2 mg to 2.o mg. 
     
     
         42 . A method of systemically administering intermittently and continuously of dilated cardiomyopathy containing trial diuretic hormone (ANP), brain sodium diuretic peptide (BNP), type C diuretic hormone (CNP), urodilatin phosphate (P-Uro), precursors or derivatives thereof over one hour or more to 24 hours or less for one administration.