Living body tissue three-dimensional model and production method therefor

Abstract

An internal tissue including a lesion region in the human body is modeled as a three-dimensional model. By reconstructing thickness or flexibility of a lumen wall portion including the lesion region and making it possible to confirm a motion of the lumen wall or a flow of fluid in the inside of the lumen wall, a state of the lesion region in the lumen can be confirmed clearly by visual inspection or the like. As a result, the diagnosis in the lumen can be made easier.

1 . A living body tissue three-dimensional model comprising a three-dimensional model of a lumen wall portion of a lumen portion of an actual living body so the three-dimensional model is a three-dimensional model of the lumen portion of the actual living body, the three-dimensional model being configured to reconstruct a thickness of the lumen wall portion of the lumen portion including a reconstructed lesion region of the actual living body. 
     
     
         2 . The living body tissue three-dimensional model according to  claim 1 , wherein the three-dimensional model includes a penetrating portion for receiving an operation instrument into the reconstructed lesion region, the penetrating portion being formed on a side face of the lumen portion. 
     
     
         3 . The living body tissue three-dimensional model according to  claim 1 , wherein the three-dimensional model is configured from at least first and second parts connected together, the first and second parts connected together each including a connecting portion, the connecting portion of the first part possessing a lumen and the connecting portion of the second part possessing a lumen, the connecting portion of the first part at least partially overlapping the connecting portion of the second part with no offset between an inside surface of the lumen of the first connecting part and an inside surface of the lumen of the second. 
     
     
         4 . The living body tissue three-dimensional model according to  claim 1 , wherein the lumen portion is a blood vessel. 
     
     
         5 . The living body tissue three-dimensional model according to  claim 1 , wherein the lesion region is a blood vessel. 
     
     
         6 . A method for producing a living body tissue three-dimensional model comprising:
 obtaining three-dimensional data of a lesion region of a living body tissue;   producing, based on the three-dimensional data of the lesion region of the living body tissue, lesion region tomographic data in which a thickness of a lumen wall portion of a lumen portion including the lesion region is reconstructed; and   lamination shaping the living body tissue three-dimensional model using the lesion region tomographic data.   
     
     
         7 . The method according to  claim 6 , further comprising coupling tomographic data three-dimensional data to the lesion region to form a penetrating portion of an operation instrument into a lesion region which has been reconstructed on a side face or an end face of the lumen portion. 
     
     
         8 . The method according to  claim 6 , further comprising coupling three-dimensional data of an overlapping coupling portion with the lesion region tomographic data so that no offset is provided on a lumen inside face region in a state in which a coupling portion of the lumen for coupling the adjacent parts to each other is coupled. 
     
     
         9 . A living body tissue three-dimensional model comprising a three-dimensional model of an actual living body lumen produced using tomographic image data of the actual living body lumen so the three-dimensional living body lumen model is a three-dimensional model of the actual living body lumen, and a plate extending from a lumen wall surrounding the lumen of the three-dimensional model so the plate projects into the lumen. 
     
     
         10 . A living body tissue three-dimensional model according to  claim 9 , further comprising a plurality of plates extending from the lumen wall surrounding the lumen of the three-dimensional model so the plurality of plates project into the lumen, the plurality of plates constituting flow indicating elements. 
     
     
         11 . A method for producing the living body tissue three-dimensional model according to  claim 9  comprising shaping the three-dimensional model using active energy-curing resin based on the tomographic image data of the living body. 
     
     
         12 . A living body tissue three-dimensional model comprising a three-dimensional model configured as an actual living body lumen and produced using tomographic image data of the actual living body lumen so the three-dimensional living body lumen model is a three-dimensional model of the actual living body lumen in which a lumen wall surrounds a lumen, the three-dimensional model comprising means for measuring displacement of the lumen wall surrounding the lumen in the three-dimensional model, the displacement being responsive to a pressure variation in the lumen. 
     
     
         13 . The living body tissue three-dimensional model according to  claim 12 , wherein the means for measuring displacement comprises one of:
 projections positioned on an outer surface of the three-dimensional model and in a predetermined spaced relationship from each other;   a thin film portion provided on the outer surface of the three-dimensional model; and   a pressure sensing section comprised of an inner side film portion, an outer side film portion and a liquid interval portion sandwiched by the inner side film portion and the outer side film portion, which are provided on the lumen wall of the three-dimensional model.   
     
     
         14 . A method for producing the living body tissue three-dimensional model according to  claim 13  comprising shaping the three-dimensional model using active energy-curing resin based on the tomographic image data of the living body. 
     
     
         15 . A living body tissue three-dimensional model comprising a three-dimensional model configured as an actual living body lumen and produced using tomographic image data of the actual living body lumen so the three-dimensional living body lumen model is a three-dimensional model of the actual living body lumen in which a lumen wall surrounds a lumen, the three-dimensional model being formed of a hardened active energy-curing resin formed by energy-curing liquid-state active energy-curing resin, the three-dimensional model also comprising a liquid-state compartment in which the liquid-state active energy-curing resin remains unhardened and is surrounded by the hardened energy-curing resin. 
     
     
         16 . A method for producing a living body tissue three-dimensional model comprising:
 producing tomographic image data of a living body;   using the tomographic image data of the living body to harden at least a portion of an active liquid-state energy-curing resin to shape and form a three-dimensional model of the living body tissue based on the tomographic image data of the living body; and   the hardening of the at least a portion of the active liquid-state energy-curing resin being performed so that the three-dimensional model of the living body tissue comprises a liquid-state compartment in which a portion of the liquid-state active energy-curing resin remains unhardened and is surrounded by the hardened resin.