Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment

Abstract

Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.

1 . A composition to treat a cancer responsive to protein kinase modulation in a mammal in need thereof, said composition comprising a therapeutically effective amount of a chalcone and a tetrahydro-isoalpha acid (THIAA); wherein said therapeutically effective amount modulates a cancer associated protein kinase. 
     
     
         2 . The composition of  claim 1 , wherein the chalcone is xanthohumol or isoxanthohumol. 
     
     
         3 . The composition of  claim 1 , wherein the composition further comprises a pharmaceutically acceptable excipient selected from the group consisting of coatings, isotonic and absorption delaying agents, binders, adhesives, lubricants, disintergrants, coloring agents, flavoring agents, sweetening agents, absorbants, detergents, and emulsifying agents. 
     
     
         4 . The composition of  claim 1 , wherein the composition further comprises one or more members selected from the group consisting of antioxidants, vitamins, minerals, proteins, fats, and carbohydrates. 
     
     
         5 . The composition of  claim 1 , wherein the tetrahydro-isoalpha acid is selected from the group consisting of tetrahydro-isohumulone, tetrahydro-isocohumulone, and tetrahydro-adhumulone. 
     
     
         6 . The composition of  claim 1 , wherein the composition further comprises a pharmaceutically acceptable excipient selected from the group consisting of coatings, isotonic and absorption delaying agents, binders, adhesives, lubricants, disintergrants, coloring agents, flavoring agents, sweetening agents, absorbants, detergents, and emulsifying agents. 
     
     
         7 . The composition of  claim 1 , wherein the composition further comprises one or more members selected from the group consisting of antioxidants, vitamins, minerals, proteins, fats, and carbohydrates.