Medical device having hydrophilic coatings

Abstract

The present invention relates to a medical device having a coating comprising at least one polyurethaneurea, wherein the coating comprises at least one polyurethane urea terminated with a copolymer unit of polyethyloxide and polypropyloxide.

1 .- 13 . (canceled) 
     
     
         14 . A medical device having at least one coating comprising at least one polyurethaneurea wherein the polyurethaneurea is terminated with a copolymer unit comprising polyethylene oxide and polypropylene oxide. 
     
     
         15 . The medical device according to  claim 14 , wherein the polyurethaneurea comprises units which originate from at least one hydroxyl-containing polycarbonate. 
     
     
         16 . The medical device according to  claim 14 , wherein the polyurethaneurea comprises units which originate from at least one aliphatic, cycloaliphatic or aromatic isocyanate. 
     
     
         17 . The medical device according to  claim 14 , wherein the polyurethaneurea comprises units which originate from at least one diamine or amine alcohol. 
     
     
         18 . The medical device according to  claim 14 , wherein the polyurethaneurea is synthesized from components comprising
 a) at least one polycarbonate polyol having an average molar weight between 400 g/mol and 6000 g/mol and a hydroxyl functionality of 1.7 to 2.3, or mixtures of such polycarbonate polyols;   b) at least one aliphatic, cycloaliphatic or aromatic polyisocyanate or mixtures of such polyisocyanates in an amount per mole of the polycarbonate polyol of 1.0 to 3.5 mol,   c) at least one aliphatic or cycloaliphatic diamine or at least one amino alcohol, as so-called chain extenders, or mixtures of such compounds in an amount per mole of the polycarbonate polyol of 0.1 to 1.5 mol,   d) at least one monofunctional mixed polyoxyalkylene ether comprising ethylene oxide and propylene oxide or a mixture of such polyethers, having an average molar weight between 500 g/mol and 5000 g/mol, in an amount per mole of the polycarbonate polyol of 0.01 to 0.5 mol,   e) optionally, one or more short-chain aliphatic polyols having a molar weight between 62 g/mol and 500 g/mol, in an amount per mole of the polycarbonate polyol of 0.05 to 1.0 mol; and   f) optionally, amine- or OH-containing units which are located on, and cap, the polymer chain ends.   
     
     
         19 . A process for coating a medical device comprising coating the medical device with at least one coating obtained from a starting solution comprising at least one polyurethaneurea wherein the polyurethaneurea is terminated with a copolymer unit comprising polyethylene oxide and polypropylene oxide. 
     
     
         20 . The process according to  claim 19 , wherein the coating is applied to the medical device by knifecoating, printing, transfer coating, spraying, spin coating or dipping. 
     
     
         21 . The process according to  claim 19 , wherein the preparation of the polyurethaneurea solution comprises
 (a) the polycarbonate polyol, the polyisocyanate, the monofunctional polyoxyalkyl ether and, optionally, the polyol are reacted with one another in the melt or in the presence of a solvent in solution, until all of the hydroxyl groups have been consumed;   (b) further solvent is added and the diamine, optionally in solution, or the amino alcohol, optionally in solution, is added; and   (c) optionally, after the target viscosity has been reached, remaining residues of NCO groups are blocked by a monofunctional aliphatic amine.   
     
     
         22 . The process according to  claim 21 , wherein the solvent is N-ethylpyrrolidone, dimethylformamide, N-methylacetamide, tetramethylurea, N-methylpyrrolidone, γ-butyrolactone, aromatic solvent, linear ester, cyclic ester, ether, ketone, alcohol or mixtures thereof. 
     
     
         23 . The process according to  claim 21 , wherein the polyurethane solution has a solids content between 5% to 60% by weight. 
     
     
         24 . A medical device obtained according to the process of  claim 19 . 
     
     
         25 . The medical device according to  claim 19 , wherein the medical device is a contact lens; a cannula; a catheter; an embolism filter; a vena caval filter; endoscope; laryngoscope; tracheal device; a guide rod; an insertion guide; a vascular plug; a pacemaker component; a drainage tube; a guide wire; a glove; a stent; a membrane; a blood filter; a device for circulatory support; a dressing material for wound management; a urine bag; a stoma bag; or a feeding tube. 
     
     
         26 . The medical device according to  claim 25 , wherein the medical device is an implant comprising a medically active agent, an implant an extracorporeal blood line, a cochlear implant, or a dental implant tube for feeding. 
     
     
         27 . The medical device according to  claim 25 , wherein the medical device is a urological catheter; a central venous catheter; an inlet catheter; an outlet catheter; a catheter for angioplasty; a catheter for biopsy; a catheter used for introducing a stent; a bronchoalveolar lavage catheter; a balloon catheter; or a catheter used in coronary angioplasty. 
     
     
         28 . The medical device according to  claim 27 , wherein the medical device is a urinary catheter or a ureteral catheter. 
     
     
         29 . The medical device according to  claim 25 , wherein the medical device is a dilation balloon. 
     
     
         30 . The medical device according to  claim 25 , wherein the medical device is an endotracheal tube, a respirator or a tracheal aspiration device. 
     
     
         31 . The medical device according to  claim 25 , wherein the medical device is a membrane for dialysis. 
     
     
         32 . The medical device according to  claim 25 , wherein the medical device comprises a medically active agent for a stent, for a balloon surface, or for a contraceptive. 
     
     
         33 . A medical device according to  claim 25  in the form of a radioactive stent, a drug-coated stent, bioabsorbable stent or a healing stent.