US2011028349A1PendingUtilityA1

Endothelial monocyte activation polypeptide II, a biomarker for use in diagnosis and treatment of brain injury

Assignee: DAVE JITENDRA RAMANLALPriority: May 18, 2006Filed: Aug 19, 2010Published: Feb 3, 2011

Est. expiryMay 18, 2026(expired)· nominal 20-yr term from priority

Inventors:Jitendra Ramanlal Dave Changping Yao Anthony Joseph Williams Xi-Chun May Frank C. Tortella Ka-Wang (Kevin) Wang Ronald L. Hayes

G01N 33/6893G01N 2333/52G01N 2800/2871G01N 33/6896G01N 2800/28G01N 33/6863

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Abstract

A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates the presence of ischemic brain injury. Detection of EMAP-II can be done in brain tissue, biofluids such as cerebrospinal fluid or blood (including plasma and serum)

Claims

exact text as granted — not AI-modified

1 - 13 . (canceled) 
     
     
         14 . A diagnostic tool comprising a differential profile containing levels of EMAP II and/or p43/EMAP II from one or more patients that have suffered traumatic brain injury and one or more patients that have suffered ischemic brain injury, and one or more control patients. 
     
     
         15 . The diagnostic tool of  claim 14 , wherein said differential profile is a high-throughput immunoblotting profile, protein chip profile, Western Blott profile or ELISA profile of said levels of EMAP II and/or p43/EMAP II. 
     
     
         16 . A diagnostic tool comprising a differential profile containing levels of EMAP II and/or p43/EMAP II, STAT3, Tau 14-3-3c protein, and PKA RII     β    from one or more patients that have suffered brain injury, and one or more control patients. 
     
     
         17 . The diagnostic tool of  claim 16 , wherein said differential profile is on a protein chip or multiplexed ELISA. 
     
     
         18 . The diagnostic tool of  claim 14 , wherein said differential profile shows a profile for traumatic brain injury with an increase of 1.6 to 1.8 fold relative to the control and a profile for ischemic brain injury with a decrease of 2.1 to 2.3 fold relative to the control. 
     
     
         19 . The diagnostic tool of  claim 14 , wherein said differential profile is a differential profile of EMAP II and/or p43/EMAP II obtained from a human patient.

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