Wound Healing

Abstract

A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound to a wound site or the skin, and optionally exposing the wound site or skin to light.

1 .- 9 . (canceled) 
     
     
         10 . A method of cosmetic treatment comprising:
 a) applying or administering to an area to be treated an effective amount of a composition comprising a compound of Formula (I)   
       
         
           
           
               
               
           
         
       
       wherein: 
       R 1 -R 6  each independently is selected from H, optionally substituted C 1-6 -alkyl, F, Cl, Br and I; 
       A and B each independently is 
       
         
           
           
               
               
           
         
       
       R 7  and R 8  each independently is selected from H and optionally substituted C 1-6 -alkyl; 
       Y is a counteranion; and 
       p is 1, 2 or 3; and
 b) optionally exposing the treated area to light, 
 
       wherein said cosmetic treatment is selected from skin rejuvenation, skin thickening, reduction of scar formation and birth mark removal. 
     
     
         11 . The method according to  claim 10 , wherein said cosmetic treatment is skin rejuvenation. 
     
     
         12 . The method according to  claim 10 , wherein said cosmetic treatment is skin thickening. 
     
     
         13 . The method according to  claim 10 , wherein said cosmetic treatment is reduction of scar formation. 
     
     
         14 . The method according to  claim 10 , wherein said cosmetic treatment is birth mark removal. 
     
     
         15 . The method according to  claim 10 , wherein said composition further comprises a pharmaceutically acceptable diluent or excipient. 
     
     
         16 . The method according to  claim 10 , wherein R 7  and R 8  are independently selected from optionally-substituted C 3-6  alkyl. 
     
     
         17 . The method according to  claim 10 , wherein Y is a counterion selected from F − , Br 5   − , Cl − , I − , NO 3   − , SCN − , ClO 3   − , ClO 4   − , IO 3   − , BF 4   − , HSO 4   − , H 2   − PO 4   − , CH 3   − SO 4   − , N 3 , SO 4   2− , HPO 4   2− , PO 4   3− , acetate, lactate, citrate, tartrate, glycolate, glycerate, glutamate, β-hydroxyglutamate, glucouronate, gluconate, malate and aspartate. 
     
     
         18 . The method according to  claim 10 , wherein R 1 , R 2 , R 3 , R 4 , R 5  and R 6  each represents H, and R 7  and R 8  represent butyl. 
     
     
         19 . A method of cosmetic treatment comprising:
 a) applying or administering to an area to be treated an effective amount of a composition comprising a compound of Formula (1)   
       
         
           
           
               
               
           
         
       
       wherein: 
       R 1 -R 6  each independently is selected from H, optionally substituted C 1-6 -alkyl, F, Cl, Br and I; 
       A and B each independently is 
       
         
           
           
               
               
           
         
       
       R 7  and R 8  each independently is selected from optionally substituted C 3-6 -alkyl; 
       Y is a counteranion; and 
       p is 1, 2 or 3; and
 b) optionally exposing the treated area to light, 
 
       wherein said cosmetic treatment is selected from skin rejuvenation, skin thickening, reduction of scar formation and birth mark removal.