Oxyntomodulin for Preventing or Treating Excess Weight

Abstract

Compositions and methods for use in the prevention or treatment of excess weight in a mammal have been developed. The compositions comprise oxyntomodulin which is shown to reduce food intake.

1 . A composition comprising oxyntomodulin, for use in the prevention or treatment of excess weight in a mammal. 
     
     
         2 . A composition comprising oxyntomodulin, for use as claimed in  claim 1 , wherein the excess weight is obesity. 
     
     
         3 . A composition comprising oxyntomodulin, for use as claimed in  claim 1  or  claim 2 , in combination with a pharmaceutically acceptable excipient. 
     
     
         4 . A composition comprising oxyntomodulin, for use as claimed in any one of  claims 1  to  3 , in liquid, solid or semi-solid form. 
     
     
         5 . A composition comprising oxyntomodulin, for use as claimed in any one of  claims 1  to  4 , wherein the mammal is a human. 
     
     
         6 . A method for the prevention or treatment of excess weight in a mammal, the method comprising administering a composition comprising oxyntomodulin to a mammal. 
     
     
         7 . A method, as claimed in  claim 6 , wherein the excess weight is obesity. 
     
     
         8 . A method for cosmetic weight loss in a mammal, the method comprising administering a composition comprising oxyntomodulin to a mammal. 
     
     
         9 . A method, as claimed in any one of  claims 6  to  8 , wherein the composition comprises oxyntomodulin and a pharmaceutically acceptable excipient or carrier. 
     
     
         10 . A method, as claimed in any of  claims 6  to  9 , wherein the weight loss is a result of reduced food intake. 
     
     
         11 . Use of oxyntomodulin, in the manufacture of a medicament for the prevention or treatment of excess weight. 
     
     
         12 . The use of oxyntomodulin to identify an agent which inhibits food intake in a mammal. 
     
     
         13 . The use, as claimed in  claim 12 , which is of the functional and/or structural characteristics of oxyntomodulin. 
     
     
         14 . The use, as claimed in  claim 12  or  claim 13 , which is of an electronically generated model of oxyntomodulin. 
     
     
         15 . The use, as claimed in any one of  claims 12  to  14 , wherein the characteristic of oxyntomodulin is its primary, secondary, tertiary structure pharmacophore and/or X-ray crystal structure. 
     
     
         16 . A composition comprising oxyntomodulin, for use in the prevention or treatment of excess weight in a mammal as hereinbefore described in the examples. 
     
     
         17 . A method for the prevention or treatment of excess weight in a mammal, the method as described with reference to the examples.