Acetylcholinesterase (ache)-derived peptide as an inducer of granulocytopoiesis, uses and methods thereof

Abstract

The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

1 . A method of inducing production of granulocytes in a subject in need thereof, comprising administering a therapeutically-effective amount of an acetylcholinesterase (AChE)-derived peptide, or functional fragments, derivatives, or a composition thereof to said subject, wherein said AChE-derived peptide is denoted by SEQ ID NO:1. 
     
     
         2 . A method of treatment of conditions that trigger low cell count of granulocytes, comprising administering a therapeutically-effective amount of an acetylcholinesterase (AChE)-derived peptide, or functional fragments, derivatives, or a composition thereof to a subject in need, wherein said AChE-derived peptide is denoted by SEQ ID NO:1. 
     
     
         3 . A method of inducing blood cells to produce cytokines, comprising obtaining said cells from a subject in need of cytokine-producing blood cells, isolating immature cells, and contacting said cells with an acetylcholinesterase (AChE)-derived peptide, or functional fragments, derivatives, or a composition thereof, wherein said AChE-derived peptide is denoted by SEQ ID NO:1.