Cellular therapeutic agent for incontinence or urine comprising stem cells originated from decidua or adipose

Abstract

The present invention relates to a cellular therapeutic agent for treating urinary incontinence, and more particularly to a cellular therapeutic agent for treating urinary incontinence, which contains stem cells derived from the decidua of the placenta or menstrual fluid or stem cells derived from adipose. The decidua-derived stem cells or adipose-derived stem cells show the effects of increasing leak point pressure and urethral sphincter contractility, and thus are useful as an agent for treating urinary incontinence.

What is claimed is: 
     
         1 . A cellular therapeutic agent for treating urinary incontinence, which contains stem cells derived from the decidua of the placenta or menstrual fluid or stem cells derived from adipose, as an active ingredient. 
     
     
         2 . The cellular therapeutic agent for treating urine incontinence according to  claim 1 , wherein the stem cells derived from the decidua of the placenta have the following characteristics:
 (a) showing immunophenotypes positive for CD29 and CD90, but negative for CD31 and CD45;   (b) showing immunophenotypes positive for Oct4, SSEA-4 and Cripto-1;   (c) growing attached to plastic, showing morphological features of round or spindle shape, and forming spheres in SFM medium so as to be able to be maintained in an undifferentiated state for a long period of time; and   (d) having the ability to differentiate into myocytes.   
     
     
         3 . The cellular therapeutic agent for treating urine incontinence according to  claim 1 , wherein the stem cells derived from adipose have the following characteristics:
 (a) showing positive immunological responses to all of CD73, CD90, CD29, CD44 and CD105, and negative immunological responses to all of CD133, CD34, CD45, CD4, CD31, CD62p, CD14 and HLA-DR; and   (b) growing attached to a plastic, showing morphological feature of spindle shape, and forming spheres in a medium containing CORM-2 so as to be able to be maintained in an undifferentiated state for a long period of time.