Vaccine composition for vaccinating dogs against canine infectious respiratory disease (cird)

Abstract

A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against Streptococcus equi sub species zooepidemicus in a dog, (b) an agent capable of raising an immune response against Mycoplasma cynos in a dog, and (c) an agent capable of raising an immune response against a Chlamydophila in a dog.

1 . An immunogenic composition comprising an agent capable of raising an immune response against  Mycoplasma cynos  ( M. cynos ) in a dog, wherein said agent comprises inactivated or attenuated  M. cynos.    
     
     
         2 . A pharmaceutical composition comprising an immunogenic composition according to  claim 1  and a pharmaceutically acceptable carrier, diluent or adjuvant. 
     
     
         3 . The immunogenic composition according to  claim 1  further comprising any one or more of:
 an agent capable of raising an immune response in a dog against canine respiratory coronavirus (CRCV); 
 an agent capable of raising an immune response in a dog against canine parainfluenzavirus (CPIV); 
 an agent capable of raising an immune response in a dog against canine adenovirus type 2 (CAV-2); 
 an agent capable of raising an immune response in a dog against canine herpesvirus (CHV); and 
 an agent capable of raising an immune response in a dog against  Bordetella bronchiseptica  ( B. bronchiseptica ). 
 
     
     
         4 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against CRCV comprises inactivated or attenuated CRCV. 
     
     
         5 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against CRCV comprises a Spike protein or a hemagglutinin-esterase (HE) protein of CRCV, or an immunogenic portion of the Spike or HE protein. 
     
     
         6 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against CPIV comprises inactivated or attenuated CPIV. 
     
     
         7 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against CAV-2 comprises inactivated or attenuated CAV-2. 
     
     
         8 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against CHV comprises inactivated or attenuated CHV. 
     
     
         9 . An immunogenic composition according to  claim 3  wherein the agent capable of raising an immune response in a dog against  B. bronchiseptica  comprises inactivated or attenuated  B. bronchiseptica.    
     
     
         10 . A method of eliciting an immune response in a dog comprising administering to the dog an immunogenic composition according to  claim 1 . 
     
     
         11 . A method of treating CIRD in a dog comprising administering to the dog an immunogenic composition according to  claim 1 . 
     
     
         12 . A method of stimulating an immune response against  M. cynos , the method comprising administering to a dog an immunogenic composition according to  claim 1 , wherein said immunogenic composition stimulates an immune response against  M. cynos  in the dog. 
     
     
         13 . The method according to  claim 12  further comprising administering to the dog any one or more of:
 an agent capable of raising an immune response against  S. zooepidemicus  in a dog; 
 an agent capable of raising an immune response against a  Chlamydophila  in a dog 
 an agent capable of raising an immune response in a dog against CRCV; 
 an agent capable of raising an immune response in a dog against CPIV; 
 an agent capable of raising an immune response in a dog against CAV-2; 
 an agent capable of raising an immune response in a dog against CHV; and 
 an agent capable of raising an immune response in a dog against  B. bronchiseptica.    
 
     
     
         14 . The immunogenic composition according to  claim 1  further comprising an agent capable of raising an immune response against  Streptococcus equi  sub species  zooepidemicus  ( S. zooepidemicus ) in a dog. 
     
     
         15 . The immunogenic composition according to  claim 1  further comprising an agent capable of raising an immune response against a  Chlamydophila  in a dog. 
     
     
         16 . An immunogenic composition comprising:
 an agent capable of raising an immune response against  M. cynos  in a dog; and   an agent capable of raising an immune response against CRCV in a dog.   
     
     
         17 . The immunogenic composition according to  claim 16  further comprising any one or more of:
 an agent capable of raising an immune response against a  Chlamydophila  in a dog; 
 an agent capable of raising an immune response in a dog against CPIV; 
 an agent capable of raising an immune response in a dog against CAV-2; 
 an agent capable of raising an immune response against CHV in a dog; and 
 an agent capable of raising an immune response in a dog against  B. bronchiseptica.    
 
     
     
         18 . The immunogenic composition according to  claim 16  further comprising:
 an agent capable of raising an immune response against  S. zooepidemicus  in a dog.