US2011065189A1PendingUtilityA1

Lacritin-Syndecan Interactions

44
Assignee: UNIV VIRGINIAPriority: Sep 17, 2007Filed: Nov 17, 2010Published: Mar 17, 2011
Est. expirySep 17, 2027(~1.1 yrs left)· nominal 20-yr term from priority
Inventors:Gordon W. LauriePeisong Ma
A61K 38/47
44
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Claims

Abstract

The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan interactions. The invention also relates to regulating lacritin-syndecan interaction to regulate ocular cell survival in response to an insult or injury, in protecting against ocular inflammation, and in promoting ocular wound repair.

Claims

exact text as granted — not AI-modified
1 .- 7 . (canceled) 
     
     
         8 . A method to enhance lacritin-syndecan-1 interactions in a cell comprising contacting a cell with heparanase. 
     
     
         9 . The method of  claim 8 , wherein the heparanase modifies syndecan. 
     
     
         10 . The method of  claim 9 , wherein the modification is the removal of a heparin sulfate moiety. 
     
     
         11 . The method of  claim 8 , wherein the heparanase deglycanates syndecan. 
     
     
         12 - 14 . (canceled)

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