US2011065898A1PendingUtilityA1

Immunosuppressant Target Proteins

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Assignee: ARIAD GENE THERAPEUTICS INCPriority: May 27, 1994Filed: Nov 25, 2009Published: Mar 17, 2011
Est. expiryMay 27, 2014(expired)· nominal 20-yr term from priority
Inventors:Vivian BerlinMaria Isabel ChiuGuillaume CottarelVeronique Damagnez
G01N 33/5091G01N 33/5008C12Q 1/6883C12Q 1/25G01N 33/502A01K 2217/05C07K 2319/00C12N 9/93C12Q 1/6897G01N 33/9493G01N 33/5005G01N 33/6845C07K 14/4702C12N 9/1205C07K 14/40G01N 33/68G01N 33/5011G01N 2500/00C12Q 2600/158C12Q 1/68C07K 14/00C12N 1/18C07K 14/47
63
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Claims

Abstract

The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes.

Claims

exact text as granted — not AI-modified
1 . A soluble polypeptide which specifically binds an FKBP/rapamycin complex, which binding is rapamycin-dependent. 
     
     
         2 - 50 . (canceled) 
     
     
         51 . A probe/primer comprising a substantially purified oligonucleotide, wherein the oligonucleotide comprises a region of nucleotide sequence which hybridizes under stringent conditions, including a wash step of 0.2×SSC at 65° C., to at least 20 consecutive nucleotides of sense or antisense sequence of SEQ ID No: 1, SEQ ID No: 11, or of the 3.74 kb gene insert of pIC524 having ATCC Accession No. 75787.

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