Methods, compositions, and kits for organ protection during systemic anticancer therapy

Abstract

Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.

1 - 71 . (canceled) 
     
     
         72 . A formulation for topical administration to a body tissue capable of establishing a local concentration of uracil in an amount sufficient to protect the tissue from toxic effects of one or more systemically distributed anticancer therapeutic agents or metabolites thereof without abrogating the clinically efficacy of said systemically distributed anticancer therapeutic agent or metabolite, the composition comprising: uracil and a pharmaceutically acceptable carrier suitable for local application. 
     
     
         73 . The formulation of  claim 72 , wherein uracil is present within said formulation at a amount by weight of least about 0.01% and less than about 60%. 
     
     
         74 . The formulation of  claim 72 , wherein uracil is present within said formulation at a amount by weight of least about 0.01% and less than about 20%. 
     
     
         75 . The formulation of  claim 72 , wherein uracil is present within said formulation at a amount by weight of least about 0.01% and less than about 10%. 
     
     
         76 . The formulation of  claim 72 , wherein uracil is present within said formulation at a amount by weight of least about 0.01% and less than about 5%. 
     
     
         77 . The formulation of  claim 72 , wherein uracil is present within said composition at a amount by weight of least about 0.01%. 
     
     
         78 . The formulation of  claim 72 , wherein uracil is present within said composition at a amount by weight of at least about 0.1%. 
     
     
         79 . The formulation of  claim 72 , wherein uracil is present within said composition at a amount by weight of at least about 1.0% 
     
     
         80 . The formulation of  claim 72 , wherein said formulation is an ointment. 
     
     
         81 . The formulation of  claim 72 , wherein said formulation is an cream. 
     
     
         82 . The formulation of  claim 72 , wherein said formulation is an spray.