COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER

Abstract

The present invention relates to a composition comprising an NFκB-inhibitor and a tropoelastin promoter, and methods of treating signs of skin aging using said compositions.

1 . A composition comprising:
 an NFκB-inhibitor; and   a tropoelastin promoter.   
     
     
         2 . The composition of  claim 1 , wherein the NFκB-inhibitor is selected from the group consisting of substituted resorcinols, (E)-3-(4-methylphenylsulfonyl)-2-propenenitrile, tetrahydrocurcuminoids, and combinations thereof. 
     
     
         3 . The composition of  claim 1 , wherein the NFκB-inhibitor is a substituted resorcinol. 
     
     
         4 . The composition of  claim 3 , wherein the substituted resorcinol comprises only substituents free of phenyl functionalities. 
     
     
         5 . The composition of  claim 3 , wherein the substituted resorcinol comprises only substituents free of ketone functionalities. 
     
     
         6 . The composition of  claim 3 , wherein the substituted resorcinol comprises at least one substituent comprising 5 to 11 carbon atoms. 
     
     
         7 . The composition of  claim 3 , wherein the substituted resorcinol comprises a single substituent, said substituent comprising 5 to 11 carbon atoms. 
     
     
         8 . The composition of  claim 3 , wherein the substituted resorcinol is selected from the group consisting of 4-hexyl resorcinol and 4-ocyl resorcinol. 
     
     
         9 . The composition of  claim 3 , wherein the substituted resorcinol is 4-hexyl resorcinol. 
     
     
         10 . The composition of  claim 1 , wherein the tropoelastin promoter is selected from the group consisting of blackberry extracts,  cotinus  extracts, feverfew extracts, extracts of  Phyllanthus niruri , and combinations thereof. 
     
     
         11 . The composition of  claim 1 , wherein the NFκB-inhibitor and the tropoelastin promoter are present in a concentration by weight ratio of about 0.001 to about 100. 
     
     
         12 . The composition of  claim 1 , further comprising a cosmetically-acceptable topical carrier. 
     
     
         13 . The composition of  claim 1 , wherein the NFκB-inhibitor has a Percent NFκB-Inhibition of at least about 35% at least one concentration from 1 microgram per milliliter to 100 micrograms per milliliter. 
     
     
         14 . The composition of  claim 1 , wherein the tropoelastin promoter has a Tropoelastin Promoter Activity of at least about 1.25 at least one concentration from 1.0 micrograms/milliliter to 2.5 micrograms/milliliter. 
     
     
         15 . A method of treating a sign of skin aging, comprising topically applying to skin in need of such treatment a composition comprising an NFκB-inhibitor and a tropoelastin promoter. 
     
     
         16 . The method of  claim 15 , wherein the NFκB-inhibitor is selected from the group consisting of substituted resorcinols, (E)-3-(4-methylphenylsulfonyl)-2-propenenitrile, tetrahydrocurcuminoids, and combinations thereof. 
     
     
         17 . The method of  claim 15 , wherein the NFκB-inhibitor is a substituted resorcinol. 
     
     
         18 . The method of  claim 17 , wherein the substituted resorcinol comprises only substituents free of phenyl functionalities. 
     
     
         19 . The method of  claim 17 , wherein the substituted resorcinol comprises only substituents free of ketone functionalities. 
     
     
         20 . The method of  claim 17 , wherein the substituted resorcinol comprises at least one substituent comprising 5 to 11 carbon atoms. 
     
     
         21 . The method of  claim 17 , wherein the substituted resorcinol comprises a single substituent, said substituent comprising 5 to 11 carbon atoms. 
     
     
         22 . The method of  claim 17 , wherein the substituted resorcinol is selected from the group consisting of 4-hexyl resorcinol and 4-ocyl resorcinol. 
     
     
         23 . The method of  claim 17 , wherein the substituted resorcinol is 4-hexyl resorcinol. 
     
     
         24 . The method of  claim 15 , wherein the tropoelastin promoter is selected from the group consisting of blackberry extracts,  cotinus  extracts, feverfew extracts, extracts of  Phyllanthus niruri , and combinations thereof. 
     
     
         25 . The method of  claim 15 , wherein the NFκB-inhibitor and the tropoelastin promoter are present in a concentration by weight ratio of about 0.001 to about 100. 
     
     
         26 . The method of  claim 15 , wherein the composition further comprises a cosmetically-acceptable topical carrier. 
     
     
         27 . The method of  claim 15 , wherein the NFκB-inhibitor has a Percent NFκB-Inhibition of at least about 35% at least one concentration from 1 microgram per milliliter to 100 micrograms per milliliter. 
     
     
         28 . The method of  claim 15 , wherein the tropoelastin promoter has a Tropoelastin Promoter Activity of at least about 1.25 when tested in a concentration of 1.0 micrograms/milliliter to 2.5 micrograms/milliliter.