Method for treating tinnitus aureum

Abstract

A method is described for treating tinnitus aureum in a subject by administering to the subject a therapeutically effective amount of a compound as defined in Formula I herein, illustratively (R)-2-acetamido-N-benzyl-3-methoxypropionamide, or a pharmaceutically acceptable salt thereof.

1 . A method of treating tinnitus aureum in a subject, comprising administering to the subject an effective amount of a compound of Formula I: 
       
         
           
           
               
               
           
         
       
       wherein:
 Ar is phenyl which is unsubstituted or substituted with at least one halo group; 
 Q is lower alkoxy containing 1-3 carbon atoms; and 
 Q 1  is methyl; 
 
       or a pharmaceutically acceptable salt thereof. 
     
     
         2 . The method of  claim 1 , wherein the compound of Formula (I) or pharmaceutically acceptable salt thereof is in the R configuration. 
     
     
         3 . The method of  claim 1 , wherein, in the compound of Formula I, Ar is unsubstituted phenyl. 
     
     
         4 . The method of  claim 1 , wherein, in the compound of Formula I, Ar is phenyl substituted with fluoro. 
     
     
         5 . The method of  claim 1 , wherein the compound of Formula I is (R)-2-acetamido-N-benzyl-3-methoxypropionamide or a pharmaceutically acceptable salt thereof. 
     
     
         6 . The method of  claim 1 , wherein the compound of Formula I is (R)-2-acetamido-N-benzyl-3-methoxypropionamide. 
     
     
         7 . The method of  claim 6 , wherein the compound is administered in a daily dosage amount of about 1 to about 600 mg. 
     
     
         8 . The method of  claim 6 , wherein the compound is administered in a daily dosage amount of about 300 to about 600 mg. 
     
     
         9 . The method of  claim 6 , wherein the compound is administered in a daily dosage amount of about 1 to about 300 mg. 
     
     
         10 . The method of  claim 6 , wherein the compound is administered in an oral dosage amount of about 1 to about 600 mg per day. 
     
     
         11 . The method of  claim 1 , wherein the compound or salt thereof is administered in a daily dosage amount of about 1 to about 600 mg. 
     
     
         12 . The method of  claim 1 , wherein the compound or salt thereof is administered in a daily dosage amount of about 1 to about 300 mg. 
     
     
         13 . The method of  claim 1 , wherein the compound or salt thereof is administered in a daily dosage amount of about 300 to about 600 mg. 
     
     
         14 . The method of  claim 1 , wherein the compound or salt thereof is administered in an oral dosage amount of about 1 to about 600 mg per day.