Purification of synthetic oligomers

Abstract

This invention provides a novel method for purifying synthetic oligomers comprising capping, polymerizing and separating any failure sequences produced during oligomer synthesis. Either the failure sequence or the full-length oligomer may be polymerized. Optionally, small molecule impurities may also be incorporated into the polymerized material. The invention provides novel capping agents having a polymerizable functional group. The invention also provides kits comprising at least one composition of the present invention.

1 . A method of purifying an oligomer comprising:
 capping any failure sequences produced during synthesis with a capping agent having a polymerizable functional group;   polymerizing the capped failure sequences; and   separating the polymerized material from the full-length oligomer; wherein the capping agent is a compound of formula (VII):   
       
         
           
           
               
               
           
         
         wherein R 1  is halogen or a secondary amine; 
         R 6  is 
       
       
         
           
           
               
               
           
         
         X is independently O or CH 2 ; and 
         n is independently an integer from 1 to 5.